N-(3,5-dimethylphenyl)-7-ethylindole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: N-(3,5-dimethylphenyl)-7-ethylindole
• 英文别名: 1-(3,5-Dimethylphenyl)-7-ethylindole
• 化学式: C₁₈H₁₉N
• 分子量: 249.356
• InChiKey: AHYPQOSFPPSYPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  7-乙基吲哚 、 3,5-二甲基溴苯 在 tris(dibenzylideneacetone)dipalladium (0) 、 sodium t-butanolate 、 1-[2-(di-tert-butylphosphino)phenyl]naphthalene 作用下， 以 甲苯 为溶剂， 生成 N-(3,5-dimethylphenyl)-7-ethylindole
  参考文献：
  名称：

  Efficient Palladium-Catalyzed N-Arylation of Indoles

  摘要：

  The N-arylation of indoles, including a variety of substituted ones, has been carried out using bulky, electron rich phosphines as the supporting ligand in combination with Pd-2(dba)(3). Using this catalyst system, the efficient coupling of indole and a variety of substituted indoles with aryl iodides, bromides, chlorides, and triflates can be achieved.

  DOI：

  10.1021/ol005728z

文献信息

• LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：EP1097158B1

  公开（公告）日：2006-01-25
• Ligands for metals and improved metal-catalyzed processes based thereon
  申请人：Massachussetts Institute of Technology

  公开号：EP1354887B1

  公开（公告）日：2007-04-25
• [EN] LIGANDS FOR METALS AND IMPROVED METAL-CATALYZED PROCESSES BASED THEREON<br/>[FR] LIGANDS POUR METAUX ET PROCESSUS PERFECTIONNES CATALYSES PAR DES METAUX BASES SUR CEUX-CI
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2000002887A2

  公开（公告）日：2000-01-20

  One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject processes provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.