5-[1-(2,4-dichlorophenyl)-1-hydroxymethyl]-2',3'-O-isopropylideneuridine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[1-(2,4-dichlorophenyl)-1-hydroxymethyl]-2',3'-O-isopropylideneuridine
• 英文别名: 1-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-5-[(2,4-dichlorophenyl)-hydroxymethyl]pyrimidine-2,4-dione
• 化学式: C₁₉H₂₀Cl₂N₂O₇
• 分子量: 459.283
• InChiKey: AIQPYKLPGIXOTH-JTGXAIIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2’,3’邻异亚丙基尿苷 、 2,4-二氯苯甲醛 在 三乙烯二胺 作用下， 以 水 为溶剂， 反应 24.0h， 以74%的产率得到5-[1-(2,4-dichlorophenyl)-1-hydroxymethyl]-2',3'-O-isopropylideneuridine
  参考文献：
  名称：

  C–C Bond Formation on 5-Position of Uridine Ring by Morita–Baylis–Hillman Type Reaction

  摘要：

  A useful and efficient C-C bond formation reaction at the 5-position of uridine derivatives using a wide range of aldehydes was established on the basis of the Morita-Baylis-Hillman type reaction.

  DOI：

  10.3987/com-09-s(s)67

文献信息

• A novel chemical modification at the 5-position of uridine derivatives
  作者：Hironao Sajiki、Akira Yamada、Kanoko Yasunaga、Takashi Tsunoda、Mumen F.A. Amer、Kosaku Hirota

  DOI：10.1016/s0040-4039(03)00155-2

  日期：2003.3

  A novel chemical modification was achieved at the 5-position of 2',3'-O-isopropylideneuridine (6) in a one-pot procedure and a remarkable effect of the base on the progress of the reaction was found. (C) 2003 Elsevier Science Ltd. All rights reserved.
• C–C Bond Formation on 5-Position of Uridine Ring by Morita–Baylis–Hillman Type Reaction
  作者：Hironao Sajiki、Yasunari Monguchi、Kanoko Yasunaga、Takashi Tsunoda、Takayuki Ando、Tomohiro Maegawa、Kosaku Hirota

  DOI：10.3987/com-09-s(s)67

  日期：——

  A useful and efficient C-C bond formation reaction at the 5-position of uridine derivatives using a wide range of aldehydes was established on the basis of the Morita-Baylis-Hillman type reaction.