5-ethyl-2,4'-bipyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-ethyl-2,4'-bipyridine
• 英文别名: 5-Ethyl-2-pyridin-4-ylpyridine
• 化学式: C₁₂H₁₂N₂
• 分子量: 184.241
• InChiKey: AIWVJNIZEDTPQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  、 4-乙酰吡啶 在 potassium tert-butylate 、 ammonium acetate 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 6.5h， 以82%的产率得到5-ethyl-2,4'-bipyridine
  参考文献：
  名称：

  Efficient Preparation of 2-Pyridylpyridines Using β-N,N-Dialkylated Aminoacroleins or their Equivalent as Vinadinium Tetrafluoroborate

  摘要：

  描述了使用 β-N,N-二烷基化氨基丙烯醛或其等效物作为二哌啶基乙烯基四氟硼酸盐合成 2-吡啶基吡啶的高效程序。

  DOI：

  10.1246/cl.2005.834

文献信息

• BIPYRIDINE-BASED COMPOUND AND ORGANIC LIGHT EMITTING DIODE EMPLOYING ORGANIC LAYER COMPRISING THE SAME
  申请人：Kim Hee-Yeon

  公开号：US20090256473A1

  公开（公告）日：2009-10-15

  The invention is directed to bipyridine-based compound and organic light emitting diodes (OLED) including organic layers having the bipyridine-based compound. OLEDs including organic layers having the bipyridine-based compounds can have low driving voltages, high current densities, high efficiencies and long lifetimes.
• EMITTERS BASED ON OCTAHEDRAL METAL COMPLEXES
  申请人：Arizona Board of Regents on behalf of Arizona State University

  公开号：US20180159051A1

  公开（公告）日：2018-06-07

  Iridium, rhodium, and platinum complexes suitable for use as phosphorescent emitters or as delayed fluorescent and phosphorescent emitters having the following structures:
• US9296695B2
  申请人：——

  公开号：US9296695B2

  公开（公告）日：2016-03-29
• [EN] ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF<br/>[FR] ANALOGUES DE L'ISOXAZOLE UTILISÉS EN TANT QU'AGONISTES DE FXR ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ENANTA PHARM INC

  公开号：WO2019118571A1

  公开（公告）日：2019-06-20

  The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.
• [EN] INHIBITORS OF SARM1<br/>[FR] INHIBITEURS DE SARM1
  申请人：DISARM THERAPEUTICS INC

  公开号：WO2020252229A2

  公开（公告）日：2020-12-17

  The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.