(13-(benzyloxy)tridecyl)triphenylphosphonium bromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (13-(benzyloxy)tridecyl)triphenylphosphonium bromide
• 英文别名: Triphenyl(13-phenylmethoxytridecyl)phosphanium;bromide
• 化学式: Br*C₃₈H₄₈OP
• 分子量: 631.676
• InChiKey: AJNWRLRWOMWEOZ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  6.49
• 重原子数：
  41
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (13-(benzyloxy)tridecyl)triphenylphosphonium bromide 在 palladium on activated charcoal 正丁基锂 、 氢气 作用下， 以 四氢呋喃 、 乙醇 、 正己烷 为溶剂， -78.0~20.0 ℃ 、101.33 kPa 条件下， 生成 14-[1-(4-Methoxyphenyl)sulfonylindol-3-yl]tetradecan-1-ol
  参考文献：
  名称：

  Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres

  摘要：

  In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

  DOI：

  10.1021/jm0493616
• 作为产物：
  描述：

  13-溴十三-1-醇 在 sodium hydride 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 生成 (13-(benzyloxy)tridecyl)triphenylphosphonium bromide
  参考文献：
  名称：

  Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres

  摘要：

  In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

  DOI：

  10.1021/jm0493616

文献信息

• How the Stereochemistry of a Central Cyclopentyl Ring Influences the Self-Assembling Properties of Archaeal Lipid Analogues: Synthesis and CryoTEM Observations
  作者：Alicia Jacquemet、Loı̈c Lemiègre、Olivier Lambert、Thierry Benvegnu

  DOI：10.1021/jo201827h

  日期：2011.12.2

  cyclopentane unit placed in the middle of tetraether archaeal bipolar lipid analogues was found to have a dramatic influence on their supramolecular self-assembling properties. The synthesis of two diastereomers varying only by the stereochemistry of the cyclopentyl unit was achieved following a multistep diastereoselective route. The corresponding lipid films were hydrated and were observed by cryoTEM

  发现位于四醚古细菌双极性脂质类似物中间的1，3-二取代的环戊烷单元的相对立体化学（顺式或反式）对其超分子自组装性能具有显着影响。遵循多步非对映选择性路线，实现了仅通过环戊基单元的立体化学变化的两种非对映异构体的合成。相应的脂质膜被水合并通过cryoTEM观察。显微照片显示了几种类型的单层纳米物体，例如顺式异构体的薄片或不规则囊泡，而反式异构体则仅显示规则球形的多层囊泡。即使环戊基环是长烷基链（32个碳原子）的一部分，
• Effects of Indole Fatty Alcohols on the Differentiation of Neural Stem Cell Derived Neurospheres
  作者：Djalil Coowar、Julien Bouissac、Mazen Hanbali、Marie Paschaki、Eliane Mohier、Bang Luu

  DOI：10.1021/jm0493616

  日期：2004.12.1

  In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13C (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.