三十五烷-18-醇 | 32119-44-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 三十五烷-18-醇
• 英文名称: 18-Hydroxypentatriacontane
• 英文别名: pentatriacontan-18-ol；18-Pentatriacontanol；Diheptadecylcarbinol；Di-n-heptadecyl-carbinol；Pentatriakontanol-(18)
• CAS: 32119-44-1
• 化学式: C₃₅H₇₂O
• 分子量: 508.956
• InChiKey: LDSNHLDVUAEZNG-UHFFFAOYSA-N

物化性质

• 熔点：
  89.5 °C
• 沸点：
  525.2±18.0 °C(Predicted)
• 密度：
  0.842±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  17.3
• 重原子数：
  36
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2905199090

反应信息

• 作为反应物：
  描述：

  三十五烷-18-醇 生成 三十五烷
  参考文献：
  名称：

  Gruen; Ulbrich; Krczil, Angewandte Chemie, 1926, vol. 39, p. 424

  摘要：

  DOI：
• 作为产物：
  描述：

  18-三十五烷酮 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 以97%的产率得到三十五烷-18-醇
  参考文献：
  名称：

  Carbamate-based cationic lipids

  摘要：

  本发明提供了一种新型基于碳酸酯的阳离子脂质，其一般结构如下：或其盐、溶剂化合物、对映异构体，其中(a) R1是一个亲脂基团；(b) R2是一个带正电荷的基团；(c) n是一个从1到8的整数；(d) X是一个阴离子或多阴离子；(e) m是一个从0到与脂质上存在的正电荷等效的数字的整数。本发明还提供了这些脂质与多阴离子大分子的组合物，利用这些组合物干扰细胞内蛋白质表达的方法，以及用于制备相同的试剂盒。

  公开号：

  US06251939B1

文献信息

• Lipids, lipid compositions, and methods of using them
  申请人：Baryza Jeremy

  公开号：US09301923B2

  公开（公告）日：2016-04-05

  Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (XI). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.

  揭示了用于将生物活性剂量有效传递至肝脏、肿瘤和/或其他细胞或组织的配方和优化协议。还提供了具有式(I)的阳离子脂质化合物的组成物和用途。该发明还涉及具有式(XI)的隐身脂质的组成物和用途。此外，还提供了制备这类化合物、组成物和配方的方法，以及利用这类化合物、组成物和配方将生物活性剂传递至细胞和/或组织的方法和用途。
• LIPIDS, LIPID COMPOSITIONS, AND METHODS OF USING THEM
  申请人：BARYZA Jeremy

  公开号：US20110200582A1

  公开（公告）日：2011-08-18

  Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (XI). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.

  本文披露了用于将生物活性剂量有效传递至肝脏、肿瘤和/或其他细胞或组织的配方和优化方案。还提供了具有化学式（I）的阳离子脂质化合物的组成和用途。该发明还涉及具有化学式（XI）的隐身脂质的组成和用途。还提供了制备这种化合物、组成物和配方的方法，以及利用这些化合物、组成物和配方将生物活性剂传递至细胞和/或组织的方法和用途。
• Novel carbamate-based cationic lipids
  申请人：Promega Biosciences, Inc.

  公开号：US20030097011A1

  公开（公告）日：2003-05-22

  The present invention provides novel carbamate-based cationic lipids of the general structure: 1 or a salt, or solvate, or enantiomers thereof wherein; (a) R 1 , is a lipophilic moiety; (b) R 2 is a positively charged moiety; (c) n is an integer from 1 to 8; (d) X − is an anion or polyanion; and (e) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.

  本发明提供了新型基于碳酸酯的阳离子脂质，其一般结构如下：1或其盐、溶剂化物或对映异构体，其中：(a) R1是一个亲脂性基团；(b) R2是一个带正电荷的基团；(c) n是一个从1到8的整数；(d) X-是一个阴离子或多阴离子；(e) m是一个从0到等于脂质上正电荷数目的整数。本发明还提供了这些脂质与多阴离子大分子的组合物、利用这些组合物干扰细胞中蛋白质表达的方法以及用于制备该组合物的试剂盒。
• Effects of Molecular Geometry on the STM Image Contrast of Methyl- and Bromo-Substituted Alkanes and Alkanols on Graphite
  作者：Christopher L. Claypool、Francesco Faglioni、Adam J. Matzger、William A. Goddard、Nathan S. Lewis

  DOI：10.1021/jp992257t

  日期：1999.11.1

  Scanning tunneling microscopy (STM) images have been collected for a series of substituted alkanes and alkanols that form ordered overlayers at room temperature on highly ordered pyrolytic graphite surfaces. Molecules that have been imaged possess an internal bromide, with or without terminal alcohol groups (HO(CH2)(9)CHBr(CH2)(10)OH and H3C(CH2)(16)CHBr(CH2)(16)CH3), an internal -OH group (H3C(CH2)(16)CHOH(CH2)(16)CH3), and an internal methyl group (H3C(CH2)(16)CHCH3(CH2)(16)CH3). These data allow comparison to the STM image contrast reported previously for molecules in which -OH, -Br, and -CH3 groups were located in terminal positions of alkane chains adsorbed onto graphite surfaces. When the functional groups were in gauche positions relative to the alkyl chain, and thus produced molecular features that protruded toward the tip, the functional groups were observed to produce bright regions in a constant current STM image, regardless of the STM contrast behavior observed for these same functional groups when they were in terminal positions of adsorbed alkyl chains. These observations are in excellent agreement with theoretical predictions of the STM behavior of such systems. Additionally, several interesting packing structures have been observed that have yielded insight into the intermolecular forces that control the packing displayed by these overlayers.
• Isomerization of Naphthalyl Chloride¹
  作者：H. E. French、J. E. Kircher

  DOI：10.1021/ja01857a012

  日期：1941.12