3,4-dideuterio-4-phenyl-2-butanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dideuterio-4-phenyl-2-butanone
• 英文别名: 3,4-dideuterio-4-phenyl-butan-2-one；3,4-Dideuterio-4-phenyl-butan-2-on；3,4-Dideuterio-4-phenylbutan-2-one
• 化学式: C₁₀H₁₂O
• 分子量: 150.189
• InChiKey: AKGGYBADQZYZPD-QTQOOCSTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苄叉丙酮 在 [PdCl)η³-C₃H₅)]₂ 六甲基二硅烷 、 重水 、 三苯基膦 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 24.0h， 以92%的产率得到3,4-dideuterio-4-phenyl-2-butanone
  参考文献：
  名称：

  Palladium-catalyzed conjugate reduction of enones into α,β-dideuterioketones with hexamethyldisilane and deuterium oxide

  摘要：

  共轭烯酮在存在催化量[PdCl(η³-C₃H₅)]₂–PPh₃的条件下，使用易得的Me₃SiSiMe₃和D₂O还原，生成α,β-二氘酮。

  DOI：

  10.1039/b618107d

文献信息

• Secondary Phosphine Oxides as Multitalented Preligands En Route to the Chemoselective Palladium-Catalyzed Oxidation of Alcohols
  作者：Alexandre Vasseur、Romain Membrat、David Gatineau、Alphonse Tenaglia、Didier Nuel、Laurent Giordano

  DOI：10.1002/cctc.201601261

  日期：2017.3.8

  Secondary phosphine oxides O=PHR2 (SPOs) were identified as multitalented preligands for the chemoselective Pd‐catalyzed oxidation of alcohols by a hydrogen‐abstracting methodology. SPOs were found to promote the hydrogen‐abstraction step as well as hydrogen transfer to a Michael acceptor by generating a putative active H−Pd species. The catalytic system operates under neutral conditions and was proven

  通过吸氢方法，仲膦氧化物O = PHR 2（SPOs）被鉴定为化学选择的Pd催化醇氧化的多态预配体。发现SPO通过产生推定的活性H-Pd物种来促进氢的吸收步骤以及氢向迈克尔受体的转移。该催化体系在中性条件下运行，并被证明与底物中的各种亲电子和亲核官能团以及对水和空气敏感的官能团兼容。
• Reduction of -Phenyl--Methylallylalcohol with Deuterium
  作者：J. B. M. COPPOCK、S. M. PARTRIDGE

  DOI：10.1038/137907a0

  日期：1936.5

  AN attempt to prepare a compound containing an asymmetric carbon atom of the form in an optically active state has been based upon the experiment of Kenyon and Partridge previously published1, in which an asymmetric synthesis is achieved by means of the following series of reactions:

  尝试制备含有旋光状态形式的不对称碳原子的化合物的尝试基于 Kenyon 和 Partridge 先前发表的实验，其中通过以下一系列反应实现不对称合成：
• Base-free transfer hydrogenation of aryl-ketones, alkyl-ketones and alkenones catalyzed by an IrIIICp* complex bearing a triazenide ligand functionalized with pyrazole
  作者：Layla J. Medrano-Castillo、Miguel Á. Collazo-Flores、Juan P. Camarena-Díaz、Erick Correa-Ayala、Daniel Chávez、Douglas B. Grotjahn、Arnold L. Rheingold、Valentín Miranda-Soto、Miguel Parra-Hake

  DOI：10.1016/j.ica.2020.119551

  日期：2020.7

  An (IrCp)-Cp-III* complex (2) bearing a triazenide ligand functionalized with pyrazole was synthesized and fully characterized by spectroscopic methods and the structure confirmed by X-ray diffraction studies. The catalytic activity of 2 and the control complex 3, which lacks of pyrazole in its structure, was evaluated in the reduction of aryl-ketones, alkyl-ketones, alpha,beta-unsaturated and gamma, delta-unsaturated ketones. The catalytic system, using either 2 or 3, exhibited good to excellent selectivity when tested with ketones and alkenones at 90 degrees C in 2-propanol as hydrogen source under base-free conditions. Reactivity of 2 in 2-propanol and NaH gave a neutral metal hydride (4) while in the absence of base gave two major cationic hydrides species (5 and 6).
• Phénylation d'alcools allyliques acycliques
  作者：William Smadja、Guy Ville、Gérard Cahiez

  DOI：10.1016/s0040-4039(01)90043-7

  日期：——
• SMADJA W.; CZERNECKI S.; VILLE G.; GEORGOULIS C., ORGANOMETALLICS, 6,(1987) N 1, 166-169
  作者：SMADJA W.、 CZERNECKI S.、 VILLE G.、 GEORGOULIS C.

  DOI：——

  日期：——