N-phenyl-1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidineacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidineacetamide
• 英文别名: N-phenyl-1-[3-(2-pyridinylethynyl)benzoyl]-4-piperdineacetamide；N-Phenyl-2-(1-(3-(pyridin-2-ylethynyl)benzoyl)piperidin-4-yl)acetamide；N-phenyl-2-[1-[3-(2-pyridin-2-ylethynyl)benzoyl]piperidin-4-yl]acetamide
• 化学式: C₂₇H₂₅N₃O₂
• 分子量: 423.514
• InChiKey: AMPSKISTSYREGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  62.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-哌啶乙酸乙酯 在 lithium hydroxide 、 copper(l) iodide 、 TEA 、 palladium dichloride 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 N-phenyl-1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidineacetamide
  参考文献：
  名称：

  Diarylacetylene piperidinyl amides as novel anxiolytics

  摘要：

  N-Phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (9) and related piperidine acetamide derivatives have good oral activity in the elevated plus maze, an animal model predictive of clinical efficacy for the treatment of anxiety. Modest affinity was observed for the neurokinin NK-1 and 2 receptors, which are known to be involved in the regulation of mood and emotion. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.027

文献信息

• Amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful for the treatment of nervous system disorders
  申请人：——

  公开号：US20020183316A1

  公开（公告）日：2002-12-05

  Novel amidoalkyl-piperidine and amidoalkyl-piperazine derivatives of the general formula 1 wherein all variables are as described herein, useful in the treatment of disorders, such as depression, dementia, schizophrenia, bipolar disorders, anxiety, emesis, acute or neuropathic pain, itching, migraine and movement disorders.

  通式如下的新型酰胺烷基哌啶和酰胺烷基哌嗪衍生物 1 其中所有变量均如本文所述，可用于治疗抑郁症、痴呆症、精神分裂症、双相情感障碍、焦虑症、呃逆、急性或神经性疼痛、瘙痒、偏头痛和运动障碍等疾病。
• Novel amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful as neurokinin receptor modulators
  申请人：Pan Kevin

  公开号：US20050004136A1

  公开（公告）日：2005-01-06

  Novel amidoalkyl-piperidine and amidoalkyl-piperazine derivatives of the general formula wherein all variables are as described herein, useful in the treatment of disorders, such as depression, dementia, schizophrenia, bipolar disorders, anxiety, emesis, acute or neuropathic pain, itching, migraine and movement disorders.

  通式为酰胺烷基哌啶和酰胺烷基哌嗪的新型衍生物 其中所有变量均如本文所述，可用于治疗抑郁症、痴呆症、精神分裂症、双相情感障碍、焦虑症、呃逆、急性或神经性疼痛、瘙痒、偏头痛和运动障碍等疾病。
• Diarylacetylene piperidinyl amides as novel anxiolytics
  作者：Cheryl P. Kordik、Chi Luo、Maryann Gutherman、Anil H. Vaidya、Daniel I. Rosenthal、Jeffrey J. Crooke、Sandra L. McKenney、Carlos R. Plata-Salaman、Allen B. Reitz

  DOI：10.1016/j.bmcl.2006.02.027

  日期：2006.6

  N-Phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (9) and related piperidine acetamide derivatives have good oral activity in the elevated plus maze, an animal model predictive of clinical efficacy for the treatment of anxiety. Modest affinity was observed for the neurokinin NK-1 and 2 receptors, which are known to be involved in the regulation of mood and emotion. (c) 2006 Elsevier Ltd. All rights reserved.