ethyl 5-cyano-6-[4-(([(2-fluorobenzyl)sulfonyl]amino)carbonyl)piperidin-1-yl]-2-(fluoromethyl)nicotinate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: ethyl 5-cyano-6-[4-(([(2-fluorobenzyl)sulfonyl]amino)carbonyl)piperidin-1-yl]-2-(fluoromethyl)nicotinate
• 英文别名: Ethyl 5-cyano-6-[4-({[(2-fluorobenzyl)sulfonyl]amino}carbonyl)piperidin-1-yl]-2-(fluoromethyl)nicotinate；ethyl 5-cyano-2-(fluoromethyl)-6-[4-[(2-fluorophenyl)methylsulfonylcarbamoyl]piperidin-1-yl]pyridine-3-carboxylate
• 化学式: C₂₃H₂₄F₂N₄O₅S
• 分子量: 506.53
• InChiKey: AMXHRTVTRUOFEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  138
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  1-(2-氟苯基)甲烷磺酰胺 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以25%的产率得到ethyl 5-cyano-6-[4-(([(2-fluorobenzyl)sulfonyl]amino)carbonyl)piperidin-1-yl]-2-(fluoromethyl)nicotinate
  参考文献：
  名称：

  WO2008/4946

  摘要：

  公开号：

文献信息

• New Pyridine Analogues III
  申请人：Antonsson Thomas

  公开号：US20080039437A1

  公开（公告）日：2008-02-14

  The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y 12 inhibitors and as anti-thrombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

  本发明涉及公式(I)的某些新吡啶类似物，以及制备这些化合物的方法，它们作为P2Y12抑制剂和抗血栓剂等的效用，它们在心血管疾病中作为药物的使用以及含有它们的制药组合物。
• Pyridine Analogues
  申请人：Andersen Soren

  公开号：US20080312208A1

  公开（公告）日：2008-12-18

  The present invention relates to certain new pyridin analogues of Formula (I) Chemical formula should be inserted here. Please see paper copy Formula (I) to processes for preparing such compounds, to their utility as P2Y 12 inhibitors and as anti-thrombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

  本发明涉及某些新的Formula (I)式吡啶类似物，化学式应在此处插入。请参见纸质副本Formula (I)，以及制备这些化合物的过程，它们作为P2Y12抑制剂和抗血栓剂等的效用，它们在心血管疾病中作为药物的用途以及含有它们的制药组合物。
• NEW PYRIDINE ANALOGUES
  申请人：AstraZeneca AB

  公开号：EP1904474A1

  公开（公告）日：2008-04-02
• [EN] NEW PYRIDINE ANALOGUES<br/>[FR] NOUVEAUX ANALOGUES DE LA PYRIDINE
  申请人：ASTRAZENECA AB

  公开号：WO2007008140A1

  公开（公告）日：2007-01-18

  [EN] The present invention relates to certain new pyridin analogues of Formula (I) Chemical formula should be inserted here. Please see paper copy Formula (I) to processes for preparing such compounds, to their utility as P2Y₁₂ inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
  [FR] La présente invention concerne certains nouveaux analogues de la pyridine de formule (I) [Formule chimique à insérer ici. Voir copie papier] (Formule (I)), des procédés servant à préparer de tels composés, leur utilité comme inhibiteurs du P2Y₁₂ et comme agents antithrombotiques, etc., leur utilisation comme médicaments dans des maladies cardiovasculaires ainsi que des compositions pharmaceutiques les contenant.
• [EN] NEW PYRIDINE ANALOGUES<br/>[FR] NOUVEAUX ANALOGUES DE PYRIDINE
  申请人：ASTRAZENECA AB

  公开号：WO2008004946A1

  公开（公告）日：2008-01-10

  [EN] The present invention relates to certain new pyridin analogues of Formula ( I ), to processes for preparing such compounds, to their utility as P2Y₁₂ inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
  [FR] La présente invention concerne de nouveaux analogues de pyridine de formule (I), des procédés de préparation de ces composé, leur utilité comme inhibiteurs de P2Y₁₂ et comme agents antithrombotiques, etc., leur utilisation comme médicaments contre des maladies cardiovasculaires, ainsi que des compositions pharmaceutiques les contenant.