(5-Methyl-pyridin-2-yl)-(5-phenyl-thiazol-2-yl)-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (5-Methyl-pyridin-2-yl)-(5-phenyl-thiazol-2-yl)-amine
• 英文别名: N-(5-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-amine
• 化学式: C₁₅H₁₃N₃S
• 分子量: 267.354
• InChiKey: ARVBLSJXBRCVTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-5-甲基吡啶 、 2-chloro-5-phenyl-thiazole 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 (5-Methyl-pyridin-2-yl)-(5-phenyl-thiazol-2-yl)-amine
  参考文献：
  名称：

  The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase

  摘要：

  An azo-dye lead was modified to a novel N-(1,3-thiazol-2-yl)pyridin-2-amine series of KDR kinase inhibitors through the use of rapid analog libraries. This new class has been found to be potent, selective, and of low molecular weight. Molecular modeling has postulated an interesting conformational preference and binding mode for these compounds in the active site of the enzyme. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.052

文献信息

• Inhibitors of LC3/Atg3 interaction and their use in the treatment of cancer
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US10807975B2

  公开（公告）日：2020-10-20

  The present inventors discovered that the molecule pyridinylthiazolamine (PTA) specifically prevents the protein-protein interaction of hLC3 with hAtg3 in vitro and in cell based assays. The inventors have developed a novel class of PTA analogs which also prevents the protein-protein interaction of hLC3 with hAtg3 in vitro, and in cell based assays, and which can be used in prior to, or in combination with chemotherapeutic agents to treat proliferative diseases such as cancer.

  本发明者发现，吡啶基噻唑胺（PTA）分子能在体外和细胞检测中特异性地阻止 hLC3 与 hAtg3 的蛋白-蛋白相互作用。本发明者开发了一类新型的 PTA 类似物，在体外和基于细胞的试验中也能阻止 hLC3 与 hAtg3 的蛋白-蛋白相互作用，可用于治疗癌症等增殖性疾病的化疗药物之前，或与化疗药物联合使用。
• US6586424B2
  申请人：——

  公开号：US6586424B2

  公开（公告）日：2003-07-01
• US6586423B2
  申请人：——

  公开号：US6586423B2

  公开（公告）日：2003-07-01
• The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase
  作者：Mark T. Bilodeau、Leonard D. Rodman、Georgia B. McGaughey、Kathleen E. Coll、Timothy J. Koester、William F. Hoffman、Randall W. Hungate、Richard L. Kendall、Rosemary C. McFall、Keith W. Rickert、Ruth Z. Rutledge、Kenneth A. Thomas

  DOI：10.1016/j.bmcl.2004.03.052

  日期：2004.6

  An azo-dye lead was modified to a novel N-(1,3-thiazol-2-yl)pyridin-2-amine series of KDR kinase inhibitors through the use of rapid analog libraries. This new class has been found to be potent, selective, and of low molecular weight. Molecular modeling has postulated an interesting conformational preference and binding mode for these compounds in the active site of the enzyme. (C) 2004 Elsevier Ltd. All rights reserved.