2-(4-methylphenylsulphonyl) ethyl acetylacetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-methylphenylsulphonyl) ethyl acetylacetate
• 英文别名: 2-(4-Methylphenyl)sulfonylethyl 3-oxobutanoate
• 化学式: C₁₃H₁₆O₅S
• 分子量: 284.333
• InChiKey: AURZAOFGQJWUOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  85.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(4-methylphenylsulphonyl) ethyl acetylacetate 、 β-氨基巴豆酸甲酯 、 乙醛 以 甲醇 、 乙醇 为溶剂， 生成 2-(4-methylphenylsulphonyl) ethyl 5-methoxycarbonyl-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
  参考文献：
  名称：

  1,4-dihydropyridine compounds with PAF-antagonistic activity

  摘要：

  描述了具有对PAF-"acether"拮抗活性的式(I)的4-烷基-1,4-二氢吡啶，其中R是饱和烷基链C1-2；R'是饱和或不饱和的C1-16直链、支链或环链，可以被氧原子中断，也可以表示2-(N-吗啉)乙基基团；n为2或3，X为氧、硫或SO2；Ar代表芳香环，当X=S且n=2时不能是苯基。化合物(I)可以通过以下方法制备：(a)通过化合物(II)与化合物(III)和(IV)的反应；或(b)通过化合物(V)与化合物(VI)和(IV)的反应；或(c)通过化合物(VII)与化合物(VI)的反应。在这些公式中，不同的基团具有上述所给含义。式(I)的化合物用于治疗PAF-"acether"参与的病理状态和疾病，例如用于治疗炎症过程、银屑病、肾小球炎、移植排斥、急性和慢性支气管炎、支气管哮喘、休克和过敏状态。同样，它用于治疗需要刺激细胞免疫力的病理状态和疾病，例如免疫缺陷综合征和其他防御能力降低的情况。

  公开号：

  US05298619A1

文献信息

• 1,4-Dihydropyridines with paf-antagonistic activity
  申请人：ALTER, S.A.

  公开号：EP0531598A1

  公开（公告）日：1993-03-17

  4-alkyl-1,4-dihydropyridines with activity antagonistic of the PAF-"aceter" of formula (I) are described, in which R is a saturated alkyl chain C1-2; R' is a saturated or unsaturated C1-16 lineal, branched or cyclic chain that can be interrupted by an oxygen atom and can also represent a 2-(N-morpholine) ethyl group; n is 2 or 3; X is oxygen, sulphur or SO2; Ar represents an aromatic ring that cannot be phenyl when X=S and n=2. The compounds (I) can be prepared (a) by reaction of (II) with (III) and with (IV); or (b) by reacting (V) with (VI) and (IV); or (c) by reaction of (VII) with (VI). In these formulas the different radicals have the meaning given above. Compounds of formula (I) are used for the treatment of pathologic states and disorders in which the PAF-"aceter" participates, being used, for example, in treatment of inflammatory processes, psoriasis, glomerulitis, transplant rejection, acute and chronic bronchitis, bronchial asthma, states of shock and allergies Likewise it is used for the treatment of pathologic states and disorders in which it is necessary to stimulate the cellular immunity such as in immunodeficient syndromes and other situations in which the defense capacity is reduced.

  描述了具有拮抗 PAF-"aceter "活性的式(I)的 4-烷基-1,4-二氢吡啶类化合物，其中 R 是饱和烷基链 C1-2；R'是饱和或不饱和 C1-16 直链、支链或环链，可被氧原子打断，也可代表 2-(N-吗啉)乙基；n 是 2 或 3；X 是氧、硫或 SO2；Ar 代表芳香环，当 X=S 和 n=2 时不能是苯基。化合物(I)可以(a)通过(II)与(III)和(IV)反应制备；或(b)通过(V)与(VI)和(IV)反应制备；或(c)通过(VII)与(VI)反应制备。在这些式子中，不同基团的含义如上。 式（I）化合物可用于治疗 PAF-"aceter "参与的病理状态和疾病，例如用于治疗炎症过程、银屑病、肾小球炎、移植排斥反应、急慢性支气管炎、支气管哮喘、休克状态和过敏。
• US5298619A
  申请人：——

  公开号：US5298619A

  公开（公告）日：1994-03-29
• 1,4-dihydropyridine compounds with PAF-antagonistic activity
  申请人：Alter, S.A.

  公开号：US05298619A1

  公开（公告）日：1994-03-29

  4-alkyl-1,4-dihydropyridines with activity antagonistic of the PAF-"acether" of formula (I) are described, in which R is a saturated alkyl chain C1-2; R' is a saturated or unsaturated C1-16 lineal, branched or cyclic chain that can be interrupted by an oxygen atom and can also represent a 2-(N-morpholine) ethyl group; n is 2 or 3, X is oxygen, sulphur or SO2; Ar represents an aromatic ring that cannot be phenyl when X=S and n=2. The compounds (I) can be prepared (a) by reaction of (II) with (III) and with (IV); or (b) by reacting (V) with (VI) and (IV); or (c) by reaction of (VII) with (VI). In these formulas the different radicals have the meaning given above. Compounds of formula (I) are used for the treatment of pathologic states and disorders in which the PAF-"acether" participates, being used, for example, in treatment of inflammatory processes, psoriasis, glomerulitis, transplant rejection, acute and chronic bronchitis, bronchial asthma, states of shock and allergies Likewise it is used for the treatment of pathologic states and disorders in which it is necessary to stimulate the cellular immunity such as in immunodeficient syndromes and other situations in which the defense capacity is reduced. ##STR1##

  描述了具有对PAF-"acether"拮抗活性的式(I)的4-烷基-1,4-二氢吡啶，其中R是饱和烷基链C1-2；R'是饱和或不饱和的C1-16直链、支链或环链，可以被氧原子中断，也可以表示2-(N-吗啉)乙基基团；n为2或3，X为氧、硫或SO2；Ar代表芳香环，当X=S且n=2时不能是苯基。化合物(I)可以通过以下方法制备：(a)通过化合物(II)与化合物(III)和(IV)的反应；或(b)通过化合物(V)与化合物(VI)和(IV)的反应；或(c)通过化合物(VII)与化合物(VI)的反应。在这些公式中，不同的基团具有上述所给含义。式(I)的化合物用于治疗PAF-"acether"参与的病理状态和疾病，例如用于治疗炎症过程、银屑病、肾小球炎、移植排斥、急性和慢性支气管炎、支气管哮喘、休克和过敏状态。同样，它用于治疗需要刺激细胞免疫力的病理状态和疾病，例如免疫缺陷综合征和其他防御能力降低的情况。