Zn(L-cysteinate)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Zn(L-cysteinate)
• 英文别名: zinc;(2R)-2-amino-3-sulfidopropanoate
• 化学式: C₃H₅NO₂S*Zn
• 分子量: 184.534
• InChiKey: AWFJSPPZIXZDKU-DKWTVANSSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.39
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  zinc(II) sulfate heptahydrate 、 L-半胱氨酸 在 ammonium hydroxide 作用下， 以 水 为溶剂， 反应 19.0h， 以87%的产率得到Zn(L-cysteinate)
  参考文献：
  名称：

  ENHANCED STABILITY OF ZINC PYRITHIONE IN OXIDATIVE ENVIRONMENTS, SUCH AS SCALP SEBACEOUS FLUID

  摘要：

  本发明公开了一种个人护理组合物，包括：（a）吡咯硫酮的多价金属盐；（b）从以下组中选择的金属配合物：其中Y1、Y2、Z1、Z2从以下组中选择：—NH2、—NHR11、—NR12R12、—NHCO—R20、—SH、—OR13、—O(C═O)—、磷酸盐。其中化合物I的Y1和Z1中至少一个是—SH，化合物II的Y2和Z2中至少一个是—SH。R1、R2、R3、R4、R5、R6、R7、R8、R9、R10可以独立地是H、烷基、取代烷基、苯基、芳基；R14是—NH2、—NHCO—CH3、—NHR17或—NR18R18；R15是—COOH、—COOR19；R11、R12、R13、R16、R17、R18、R19可以独立地是烷基、取代烷基、苯基、芳基。配合物的金属来自锌、铜和铁。

  公开号：

  US20200405600A1

文献信息

• Chiral II−VI Semiconductor Nanostructure Superlattices Based on an Amino Acid Ligand
  作者：Jean-Noël Rebilly、Paul W. Gardner、George R. Darling、John Bacsa、Matthew J. Rosseinsky

  DOI：10.1021/ic801097w

  日期：2008.10.20

  Reaction of L-cysteine with M(NO3)(2)center dot xH(2)O (M = Cd, Zn) generates M(L-Cysteinate), which feature one-dimensional substructures that can be viewed as fragments of bulk structures of CdS (rock salt high pressure phase) and ZnS (wurtzite) because of the bridging modes accessible to the sulfur atom Of L-cysteine. The MS substructures are arranged in a regular and periodic fashion within the crystal via the carboxylate function Of L-cysteine. Considering the structural similarities with bulk materials, the optical properties of M(L-cysteinate) were studied and indicate blue shifts of the band gap of 2.59 eV (M = Cd, compared to CdS rock salt) and 1.37 eV (M = Zn, compared to ZnS wurtzite) with respect to the bulk MS structures, due to the low dimensionality of the metal-sulfur arrangement. The chelating nature of the cysteine ligand imposes an unusual mer arrangement of three binding S moieties at Cd with a correspondingly high Cd coordination number in a chalcogenide-based material. Density of states calculations show strong electronic structure similarities with the bulk phases and rationalize the band gap changes.
• ENHANCED STABILITY OF ZINC PYRITHIONE IN OXIDATIVE ENVIRONMENTS, SUCH AS SCALP SEBACEOUS FLUID
  申请人：The Procter & Gamble Company

  公开号：US20200405600A1

  公开（公告）日：2020-12-31

  The present invention discloses a personal care composition comprising: (a) A polyvalent metal salt of pyrithione; (b) A metal complex selected from the group consisting of: wherein Y 1 , Y 2 , Z 1 , Z 2 are selected from the following groups: —NH 2 , —NHR 11 , —NR 12 R 12 , —NHCO—R 20 , —SH, —OR 13 , —O(C═O)—, phosphate. and wherein at least one of Y 1 and Z 1 of compound I is —SH, and wherein at least one of Y 2 and Z 2 of compound II is —SH R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , can independently be H, alkyl, substituted alkyl, phenyl, aryl; R 14 is —NH 2 , —NHCO—CH 3 , —NHR 17 , or —NR 18 R 18 R 15 is —COOH, —COOR 19 R 11 , R 12 , R 13 R 16 , R 17 , R 18 , R 19 can be independently be alkyl, substituted alkyl, phenyl, aryl. and wherein the metal of the complex is selected from the group consisting of zinc, copper, and iron.

  本发明公开了一种个人护理组合物，包括：（a）吡咯硫酮的多价金属盐；（b）从以下组中选择的金属配合物：其中Y1、Y2、Z1、Z2从以下组中选择：—NH2、—NHR11、—NR12R12、—NHCO—R20、—SH、—OR13、—O(C═O)—、磷酸盐。其中化合物I的Y1和Z1中至少一个是—SH，化合物II的Y2和Z2中至少一个是—SH。R1、R2、R3、R4、R5、R6、R7、R8、R9、R10可以独立地是H、烷基、取代烷基、苯基、芳基；R14是—NH2、—NHCO—CH3、—NHR17或—NR18R18；R15是—COOH、—COOR19；R11、R12、R13、R16、R17、R18、R19可以独立地是烷基、取代烷基、苯基、芳基。配合物的金属来自锌、铜和铁。