谷氨酰-天冬氨酰胺酰-天冬氨酰-酪氨酰-异亮氨酰-天冬氨酰胺酰-丙氨酰-丝氨酰-亮氨酸 | 154301-48-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 谷氨酰-天冬氨酰胺酰-天冬氨酰-酪氨酰-异亮氨酰-天冬氨酰胺酰-丙氨酰-丝氨酰-亮氨酸
• 英文名称: ENDYINASL
• 英文别名: Glutamyl-asparaginyl-aspartyl-tyrosyl-isoleucyl-asparaginyl-alanyl-seryl-leucine；(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoic acid
• CAS: 154301-48-1
• 化学式: C₄₄H₆₇N₁₁O₁₈
• 分子量: 1038.08
• InChiKey: YWYBJTRQRSRIAG-IRRGQOHVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.6
• 重原子数：
  73
• 可旋转键数：
  33
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  497
• 氢给体数：
  16
• 氢受体数：
  19

反应信息

• 作为产物：
  描述：

  ENDpYINASL 在 NtPAP₁₂ 作用下， 生成 谷氨酰-天冬氨酰胺酰-天冬氨酰-酪氨酰-异亮氨酰-天冬氨酰胺酰-丙氨酰-丝氨酰-亮氨酸
  参考文献：
  名称：

  Purple acid phosphatase in the walls of tobacco cells

  摘要：

  Purple acid phosphatase isolated from the walls of tobacco cells appears to be a 220 kDa homotetramer composed of 60 kDa subunits, which is purple in color and which contains iron as its only metal ion. Although the phosphatase did not require dithiothreitol for activity and was not inhibited by phenylarsine oxide, the enzyme showed a higher catalytic efficiency (k(cat)/K-m) for phosphotyrosine-containing peptides than for other substrates including p-nitrophenyl-phosphate and ATP. The phosphatase formed as a 120 kDa dimer in the cytoplasm and as a 220 kDa tetramer in the walls, where Brefeldin A blocked its secretion during wall regeneration. According to our double-immunofluorescence labeling results, the enzyme might be translocated through the Golgi apparatus to the walls at the interphase and to the cell plate during cytokinesis. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2008.07.008

文献信息

• Purple acid phosphatase in the walls of tobacco cells
  作者：Rumi Kaida、Takahisa Hayashi、Takako S. Kaneko

  DOI：10.1016/j.phytochem.2008.07.008

  日期：2008.10

  Purple acid phosphatase isolated from the walls of tobacco cells appears to be a 220 kDa homotetramer composed of 60 kDa subunits, which is purple in color and which contains iron as its only metal ion. Although the phosphatase did not require dithiothreitol for activity and was not inhibited by phenylarsine oxide, the enzyme showed a higher catalytic efficiency (k(cat)/K-m) for phosphotyrosine-containing peptides than for other substrates including p-nitrophenyl-phosphate and ATP. The phosphatase formed as a 120 kDa dimer in the cytoplasm and as a 220 kDa tetramer in the walls, where Brefeldin A blocked its secretion during wall regeneration. According to our double-immunofluorescence labeling results, the enzyme might be translocated through the Golgi apparatus to the walls at the interphase and to the cell plate during cytokinesis. (C) 2008 Elsevier Ltd. All rights reserved.