5-pyrrolidinyl-4,5-dioxopentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 5-pyrrolidinyl-4,5-dioxopentanoic acid
• 英文别名: 5-pyrrolidyl-4,5-dioxopentanoic acid；4,5-dioxo-5-pyrrolidin-1-ylpentanoic acid
• 化学式: C₉H₁₃NO₄
• 分子量: 199.207
• InChiKey: AXAQZDZPNQYXHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  苯硫酚 、 5-pyrrolidinyl-4,5-dioxopentanoic acid 生成 5-(benzenesulfonyl)-5-(pyrrolidine-1-carbonyl)oxolan-2-one
  参考文献：
  名称：

  YOSHIOKA, KOUICHI

  摘要：

  DOI：
• 作为产物：
  描述：

  alpha-酮戊二酸 生成 5-pyrrolidinyl-4,5-dioxopentanoic acid
  参考文献：
  名称：

  JOSIOKA, KOITI

  摘要：

  DOI：

文献信息

• Antibiotic
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04851422A1

  公开（公告）日：1989-07-25

  The compound represented by the formula: ##STR1## where R.sup.1 stands for amino or an organic residue bonded through nitrogen; R.sup.2 stands for carboxyl or a group derivable therefrom; R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently stand for hydrogen or an organic residue, including the case where R.sup.5 or R.sup.6 forms a chemical bond or a ring with R.sup.7 or R.sup.8 ; X stands for hydrogen, methoxy or formylamino; or a salt thereof, produceable by the present method, exhibits excellent antimicrobial activity, and is utilized as antimicrobial agents.

  该化合物由以下结构式表示：##STR1## 其中，R1代表氨基或通过氮原子连接的有机残基；R2代表羧基或由此衍生的基团；R3、R4、R5、R6、R7和R8各自独立地代表氢或有机残基，包括R5或R6与R7或R8形成化学键或环的情况；X代表氢、甲氧基或甲酰氨基；或其盐，可通过本方法制备，表现出优异的抗菌活性，并被用作抗菌剂。
• Gamma-lactonecarboxylic acid derivatives and their use as antibacterial
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04882434A1

  公开（公告）日：1989-11-21

  A compound represented by formula (I): ##STR1## wherein R.sup.1 is an organic residue through a carbon atom, R.sup.2 is a carboxyl group which may be esterified or amidated, and X is an oxygen atom, or a sulfur atom which may be oxidized, or a salt thereof, which is useful as antibacterial agent or intermediate for synthesizing the same, and a process for preparing the same.

  公式(I)所代表的化合物：##STR1## 其中R.sup.1是通过一个碳原子连接的有机残基，R.sup.2是可以酯化或酰胺化的羧基，X是一个氧原子或者可以被氧化的硫原子，或其盐。该化合物可用作抗菌剂或合成该抗菌剂的中间体，并提供其制备方法。
• Antibiotic derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0219923A1

  公开（公告）日：1987-04-29

  The compound represented by the formula: where R' stands for amino or an organic residue bonded through nitrogen; R2 stands for carooxyl ora group derivable therefrom; R3, R4, R5, R6, R7 and R8 independently stand for hydrogen or an organic residue, including the case where R5 or R6 forms a chemical bond or a ring with R7 or R8: X stands for hvdrogen, methoxy or formylamino; or a salt thereof, pro- duceaole by the present method. exnibits excellent antimicrobial activity, and is utilized as antimicrobial agents.

  式所代表的化合物： 其中，R'代表氨基或通过氮键结合的有机残基；R2代表甲氧羰基或可由其衍生的基团；R3、R4、R5、R6、R7 和 R8 分别代表氢或有机残基，包括 R5 或 R6 与 R7 或 R8 形成化学键或环状的情况：X 代表氢、甲氧基或甲酰氨基；或其盐，通过本方法制得。它们具有优异的抗菌活性，可用作抗菌剂。
• Gamma-lactonecarboxylic acid derivatives and their production
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0266182A2

  公开（公告）日：1988-05-04

  A compound represented by formula (I): , wherein R¹ is an organic residue through a carbon atom, R² is a carboxyl group which may be esterified or amidated, and X is an oxygen atom, or a sulfur atom which may be oxidized, or a salt thereof, which is useful as antibacterial agent or intermediate for synthesizing the same, and a process for preparing the same.

  一种由式(I)代表的化合物： 其中 R¹ 是通过碳原子的有机残基，R² 是可被酯化或酰胺化的羧基，X 是氧原子或可被氧化的硫原子、 或其盐，可用作抗菌剂或合成抗菌剂的中间体，以及制备抗菌剂的工艺。
• JOSIOKA, KOITI
  作者：JOSIOKA, KOITI

  DOI：——

  日期：——