谷氨酸-赖氨酸-酪氨酸三元聚合物 | 28675-46-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 谷氨酸-赖氨酸-酪氨酸三元聚合物
• 英文名称: H-Tyr-OH.H-Lys-OH.H-Glu-OH
• 英文别名: (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2S)-2-aminopentanedioic acid;(2S)-2,6-diaminohexanoic acid
• CAS: 28675-46-9
• 化学式: C20H34N4O9
• 分子量: 474.5
• InChiKey: CVTKMOLUOFOZAO-NEJMAHLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.86
• 重原子数：
  33
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  274
• 氢给体数：
  9
• 氢受体数：
  13

文献信息

• USE OF DPAS AND CO-POLYMERS FOR HYPERLIPIDEMIA AND ATHEROSCLEROSIS ALONG WITH REDUCING FEEDING RATE AND ADIPOSE TISSUE WEIGHT OF OBESITY ANIMAL
  申请人：Chen Ing-Jun

  公开号：US20130202549A1

  公开（公告）日：2013-08-08

  The disubstituted piperazine analogs (DPAs) derivative compound and DPAs amine complex compound disclosed in the present aspects have characterized by presented pharmaceutics having functions to improve lipolysis, such as inhibiting obesity hyperlipidemia, and atherosclerosis.

  本方面披露的二取代哌嗪类似物（DPAs）衍生物化合物和DPAs胺配合物化合物具有改善脂肪分解功能的特性，如抑制肥胖、高脂血症和动脉粥样硬化。
• Adsorbent of beta 2-microglobulin
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0319144A1

  公开（公告）日：1989-06-07

  An adsorbent for β2-microglobulin is disclosed, which comprises a water-insoluble carrier having supported thereon, as a ligand, at least one electrolyte selected from the group consisting of a polyamino acid, a polysaccharide, a synthetic high polymer, collagen having an isoelectric point of 9.5 or more, and gelatin having an isoelectric point of 6.5 or more, wherein said electrolyte has a molecular weight not less than 1,000 and an X value of more than 2.0, wherein X is a relationship regarding the skeleton structure of said electrolyte and is the sum of A and B, wherein A represents (the number of carbon atoms of the skeleton structure) - (the number of hydrophilic groups /(the number of hydrophilic groups); and B represents |(the number of cationic groups) - (the number of anionic groups)l/(the number of hydrophilic groups). The adsorbent exhibits adsorptivity for β2- microglobulin at high efficiency and high selectivity.

  本发明公开了一种用于吸附β2-微球蛋白的吸附剂，它包括一种水不溶性载体，其上作为配体支撑着至少一种电解质，该电解质选自由聚氨基酸、多糖、合成高聚物、等电点大于或等于 9.5 的胶原蛋白和等电点大于或等于 6.5 的明胶组成的组，其中所述电解质的分子量不小于 1 000，X 值大于 2.0，其中X是关于所述电解质的骨架结构的关系，是A和B的总和，其中A代表(骨架结构的碳原子数)-(亲水基团数/(亲水基团数))；B代表|(阳离子基团数)-(阴离子基团数)l/(亲水基团数)。该吸附剂对 β2- 微球蛋白具有高效率和高选择性的吸附能力。
• Treatment of autoimmune conditions with copolymer 1 and related copolymers and peptides
  申请人：YEDA RESEARCH AND DEVELOPMENT CO., LTD.

  公开号：EP2327712A2

  公开（公告）日：2011-06-01

  The present invention is directed to polypeptides and peptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides or peptides to the mammal.

  本发明涉及含有至少三个以线性排列方式随机连接的氨基酸的多肽；其中三个氨基酸中至少有一个是芳香族氨基酸，三个氨基酸中至少有一个是带电氨基酸，至少有一个氨基酸是脂肪族氨基酸。在一个优选的实施方案中，多肽含有以下三种或四种氨基酸：酪氨酸、丙氨酸、谷氨酸或赖氨酸。根据本发明，本多肽可与抗原呈递细胞、纯化的人类淋巴细胞抗原（HLA）和/或共聚物 1 特异性 T 细胞结合。此外，根据本发明，这些多肽可配制成药物组合物，用于治疗自身免疫性疾病。本发明进一步考虑了通过向哺乳动物施用药学有效量的任一种本发明多肽或肽来治疗哺乳动物自身免疫性疾病的方法。
• Synthetic peptides and methods of use for autoimmune disease therapies
  申请人：President and Fellows of Harvard College

  公开号：US20040006022A1

  公开（公告）日：2004-01-08

  The invention provides peptide compositions, and methods of making and using therapeutic compositions for treatment of a subject for an autoimmune or an inflammatory disease. The invention also provides kits for assaying binding of a composition to a water-soluble MHC protein.

  本发明提供了多肽组合物，以及制造和使用治疗组合物的方法，用于治疗自身免疫性或炎症性疾病。本发明还提供了检测组合物与水溶性 MHC 蛋白结合的试剂盒。
• TREATMENT OF AUTOIMMUNE CONDITIONS WITH COPOLYMER 1 AND RELATED COPOLYMERS AND PEPTIDES
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：EP1098902A1

  公开（公告）日：2001-05-16