4-isopropylphenyl 2,2-dimethylpropionate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 4-isopropylphenyl 2,2-dimethylpropionate
• 英文别名: Pivalic acid, 4-isopropylphenyl ester；(4-propan-2-ylphenyl) 2,2-dimethylpropanoate
• 化学式: C₁₄H₂₀O₂
• 分子量: 220.312
• InChiKey: AXVKQFBAUKDDIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-isopropylphenyl 2,2-dimethylpropionate 在 (S,S)-Mn(pdp) 、 双氧水 、 溶剂黄146 作用下， 以 乙腈 为溶剂， 反应 2.0h， 生成 C₁₄H₂₀O₃
  参考文献：
  名称：

  Comparative Study of the Limitations and Challenges in Atom-Transfer C–H Oxidations

  摘要：

  A comparative study is disclosed that seeks to highlight the current limitations and challenges that exist in the field of atom-transfer C-H oxidations. State-of-the-art methods are benchmarked in order to showcase clear differences and similarities. A novel Mn-mediated method for C-H oxidation is disclosed that serves as a rapid and simple method for aliphatic C-H hydroxylation. Finally, two methods that allow for C-H oxidation in the presence of pyridine-containing substrates are studied, something that is rare in the field but of great interest to the chemical community.

  DOI：

  10.1021/acs.orglett.5b03047
• 作为产物：
  描述：

  4-异丙基苯酚 、 三甲基乙酰氯 在 氢氧化钾 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 2.5h， 以66.7%的产率得到4-isopropylphenyl 2,2-dimethylpropionate
  参考文献：
  名称：

  WO2007/4753

  摘要：

  公开号：

文献信息

• Regioselective Ortho‐C H sulfenylation of free phenols catalyzed by Co(II)-immobilized on silica-coated magnetic nanoparticles
  作者：Sepideh Khaef、Abed Rostami、Vahid Khakyzadeh、Mohammad Ali Zolfigol、Avat Arman Taherpour、Meysam Yarie

  DOI：10.1016/j.mcat.2020.110772

  日期：2020.3

  Fe3O4@SiO2[email protected]II is prepared by the silica-coated magnetic nanoparticles, urea-triazole, and CoCl2. This organic-inorganic hybride composite showed a good to excellent catalytic activity toward regioselective ortho-sulfenylation of free phenols and naphthols using pivalic anhydride as a directing group, also K2S2O8 and PPh3 were employed as oxidant and additive respectively. The newly

  Fe 3 O 4 @SiO 2 [电子邮件保护] II是通过二氧化硅包覆的磁性纳米颗粒，脲三唑和CoCl 2制备的。这种有机-无机杂化复合物，使用新戊酸酐，K 2 S 2 O 8和PPh 3作为导向基团，对游离酚和萘的区域选择性邻亚磺酰化表现出良好至优异的催化活性。分别用作氧化剂和添加剂。通过使用不同的技术（例如FT-IR，TGA，DTG，TEM，SEM，EDS，ICP和VSM分析）对新合成的催化剂进行了全面表征。与用于C H键活化和官能化的昂贵过渡金属相比，钴具有竞争力的价格，可及性和较低的毒性构成了该方法的宝贵优势。而且，这种多相催化剂可以在五个循环后被磁回收和再利用而不会显着损失其催化活性。
• Nickel(0)-Catalyzed Heck Cross-Coupling via Activation of Aryl C–OPiv Bonds
  作者：Andrew R. Ehle、Qi Zhou、Mary P. Watson

  DOI：10.1021/ol203322v

  日期：2012.3.2

  Using a Ni(dppf) catalyst generated in situ, Heck cross-coupling of aryl pivalates with a variety of olefin partners has been accomplished. This method represents one of the first examples of a C C cross-coupling via activation of a strong C-O bond with a nonorganometallic coupling partner. It enables the transformation of phenol-based substrates into styrenyl products without generation of a halogenated byproduct or the use of expensive triflate groups.
• RESIN, RESIST COMPOSITION AND METHOD FOR PRODUCING RESIST PATTERN
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20160291467A1

  公开（公告）日：2016-10-06

  A resist composition contains: a resin having an acid-labile group, a resin having a structural unit represented by formula (I), an acid generator, and a solvent; wherein R i41 represents a hydrogen atom or a methyl group, R i42 represents a C 1 to C 10 hydrocarbon group that may be substituted with a hydroxy group, a C 2 to C 7 acyl group or a hydrogen atom, R i43 in each occurrence independently represents a C 1 to C 6 alkyl group or a C 1 to C 6 alkoxy group, “p” represents an integer of 0 to 4, Z represents a divalent C 3 to C 20 hydrocarbon group having a group represented by formula (Ia), and a methylene group contained in the hydrocarbon group may be replaced by an oxygen atom, a sulfur atom or a carbonyl group, *—[(CH 2 ) w —O] r — (Ia): wherein “w” and “r” each independently represents an integer of 1 to 10, and * represent a bonding position.
• [EN] ALKYLPHENOL DERIVATIVES HAVING PHYTOPATHOGENIC FUNGI ACTIVITIES<br/>[FR] DÉRIVÉS D'ALKYLPHÉNOL PRÉSENTANT UNE ACTIVITÉ CONTRE LES CHAMPIGNONS PHYTOPATHOGÈNES
  申请人：DONGBU HANNONG CHEMICALS CO LT

  公开号：WO2007004753A1

  公开（公告）日：2007-01-11

  [EN] Disclosed herein is an alkylphenol derivative having inhibitory activities on the growth of phytopathogenic fungi, represented by Formula 1, and a growth inhibitor for phytopathogenic fungi containing the alkylphenol derivative as an effective component. The alkylphenol derivative of this invention may exhibit excellent inhibitory activities on the growth of phytopathogenic fungi, for example, Phytophthora infestans, Pyrcularia grisea, Alternaria alternata f. sp. mali, Colletotrichum orbiculare, Rhizoctonia solini, Colletotrichum gloeasporioid.es, Botrytis cinerea, and Phytophthora capsici, and thus, may be used as an environmentally friendly disinfecting agent.
  [FR] La présente invention décrit un dérivé d'alkylphénol, représenté par la formule 1, qui présente une activité inhibitrice sur la croissance de champignons phytopathogènes, ainsi qu'un inhibiteur de croissance de champignons phytopathogènes qui comprend les dérivés d'alkylphénol comme composant efficace. Le dérivé d'alkylphénol de la présente invention peut présenter une excellente activité inhibitrice sur la croissance de champignons phytopathogènes, par exemple, Phytophthora infestans, Pyrcularia grisea, Alternaria alternata f. sp. mali, Colletotrichum orbiculare, Rhizoctonia solini, Colletotrichum gloeasporioid.es, Botrytis cinerea et Phytophthora capsici, et il peut ainsi être utilisé comme agent désinfectant écologique.
• Comparative Study of the Limitations and Challenges in Atom-Transfer C–H Oxidations
  作者：Ashley M. Adams、J. Du Bois、Hasnain A. Malik

  DOI：10.1021/acs.orglett.5b03047

  日期：2015.12.18

  A comparative study is disclosed that seeks to highlight the current limitations and challenges that exist in the field of atom-transfer C-H oxidations. State-of-the-art methods are benchmarked in order to showcase clear differences and similarities. A novel Mn-mediated method for C-H oxidation is disclosed that serves as a rapid and simple method for aliphatic C-H hydroxylation. Finally, two methods that allow for C-H oxidation in the presence of pyridine-containing substrates are studied, something that is rare in the field but of great interest to the chemical community.