2-(4-methoxyphenyl)-6-methyl-4-phenylpyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(4-methoxyphenyl)-6-methyl-4-phenylpyridine
• 英文别名: 6-(4-methoxyphenyl)-2-methyl-4-phenylpyridine
• 化学式: C₁₉H₁₇NO
• 分子量: 275.35
• InChiKey: AYKHGNHKZMVFPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(4-methoxybenzylidene)-3-phenylisoxazol-5(4H)-one 在 对氟苯甲酸 、 邻甲氧基苯胺 、 铁粉 、 3,5-二甲氧基苯甲酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 168.0h， 生成 2-(4-methoxyphenyl)-6-methyl-4-phenylpyridine
  参考文献：
  名称：

  An Aminocatalyzed Michael Addition/Iron-Mediated Decarboxylative Cyclization Sequence for the Preparation of 2,3,4,6-Tetrasubstituted Pyridines: Scope and Mechanistic Insights

  摘要：

  A novel, scalable strategy for the preparation of 2,3,4,6-tetrasubstituted pyridines is described. This protocol has two steps: an aminocatalyzed addition of ketones to alkylidene isoxazol-5-ones, followed by an iron-mediated decarboxylative cyclization event. Mechanistic insights for both steps are provided based on HRMS-ESI(+) studies.

  DOI：

  10.1021/acs.joc.7b01789

文献信息

• Shibata, Katsuyoshi; Katsuyama, Isamu; Izoe, Hideaki, Journal of Heterocyclic Chemistry, 1993, vol. 30, # 1, p. 277 - 281
  作者：Shibata, Katsuyoshi、Katsuyama, Isamu、Izoe, Hideaki、Matsui, Masaki、Muramatsu, Hiroshige

  DOI：——

  日期：——
• An Aminocatalyzed Michael Addition/Iron-Mediated Decarboxylative Cyclization Sequence for the Preparation of 2,3,4,6-Tetrasubstituted Pyridines: Scope and Mechanistic Insights
  作者：Mateus L. Stivanin、Marcelo Duarte、Camila Sartori、Naylil M. R. Capreti、Celio F. F. Angolini、Igor D. Jurberg

  DOI：10.1021/acs.joc.7b01789

  日期：2017.10.6

  A novel, scalable strategy for the preparation of 2,3,4,6-tetrasubstituted pyridines is described. This protocol has two steps: an aminocatalyzed addition of ketones to alkylidene isoxazol-5-ones, followed by an iron-mediated decarboxylative cyclization event. Mechanistic insights for both steps are provided based on HRMS-ESI(+) studies.