(2R)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carboxamide
• 化学式: C₈H₁₅N₃O₂
• 分子量: 185.22
• InChiKey: OCUQILXOPJOUAM-NTSWFWBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  89.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] CYCLIC TETRAPEPTIDES<br/>[FR] TÉTRAPEPTIDES CYCLIQUES
  申请人：UNIV KANSAS

  公开号：WO2010006267A2

  公开（公告）日：2010-01-14

  Cyclic tetrapeptides that are kappa opioid receptor (KOR) antagonists can be used in therapeutic applications for treating, inhibiting, and/or preventing drug addiction, drug use, or drug seeking behavior in a subject. This can include subjects that have a history of drug addiction. The drug can be selected from cocaine, alcohol, amphetamines, methamphetamines, nicotine, opiate, or combinations thereof. These cyclic tetrapeptides can also be useful for treating, inhibiting, and/or preventing stress-induced drug seeking behavior.