(2R)-2-Amino-3-(cyclopent-1-en-1-yl)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-Amino-3-(cyclopent-1-en-1-yl)propanoic acid
• 英文别名: (2R)-2-amino-3-(cyclopenten-1-yl)propanoic acid
• 化学式: C₈H₁₃NO₂
• 分子量: 155.19
• InChiKey: MNHWYCRCODAGAH-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] PEPTIDE BEADS<br/>[FR] BILLES À BASE DE PEPTIDES
  申请人：UNIV BASEL

  公开号：WO2013004716A1

  公开（公告）日：2013-01-10

  The invention relates to peptide beads comprising amphiphilic bead-forming peptides of the formula R1 (A1)k (A2 D-A3)m (A2)n (A1)l R2, wherein R1 is an amino acid, biotin, an acyl group or hydrogen, R2 is NH2, OH, alkoxy, hydroxyethylamide or an optionally amidated amino acid, or biotin; A1 is a hydrophilic L-amino acid; A2 is an aromatic L-amino acid; A3 is an aliphatic D-amino acid; k and l are, independently of each other, between 0 and 12; m is between 2 and 8; and n is 0 or 1; a mediator peptide of the formula R1 (A1)k (A2 D-A3)m (A2)n (A1)l R2, wherein at least one of the substituents R1, R2 and/or at least one of the amino acids A1 is different from the corresponding substituents R1, R2 and/or amino acids A1 in the peptide forming the peptide beads; and a payload, such as RNA, DNA or hydrophilic drug, furthermore to the use of such peptide beads for the delivery of an active pharmaceutical ingredient into tissue and cells, and the release of the active pharmaceutical ingredient in the tissue or cell causing the desired therapeutic effect.