N-acryloyl-1,4-diaminobutane hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acryloyl-1,4-diaminobutane hydrochloride
• 英文别名: N-(4-aminobutyl)prop-2-enamide;hydrochloride
• 化学式: C₇H₁₄N₂O*ClH
• 分子量: 178.662
• InChiKey: BANNFPLOEUCPAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.45
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  55.1
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,5-吡啶二甲酰氯 、 N-acryloyl-1,4-diaminobutane hydrochloride 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.17h， 以51%的产率得到N³,N⁵-bis(4-acrylamidobutyl)pyridine-3,5-dicarboxamide
  参考文献：
  名称：

  Synthesis of Pyridine Acrylates and Acrylamides and Their Corresponding Pyridinium Ions as Versatile Cross-Linkers for Tunable Hydrogels

  摘要：

  A small library of cross-linkers for hydrogels was synthesized. The cross-linkers consisted of 2,6- and 3,5-diacylpyridine or 2,4,6-triacylpyridine as the core unit, which were tethered via ethylene glycol, amino ethanol, and 1,n-diamine spacers to terminal acrylate or acrylamide moieties. Esterification and amide formation of the terminal acryl units were found to be dependent on the ratio of NH/O in the spacer, the constitution pattern of the pyridine ring, and the total number of acryl groups. Thus, esters generally gave higher yields than amides decreasing with increasing number of NH in the spacer and with increasing number of acryl units. In the case of 3,5-diacylpyridine derivatives, these trends were less prominent as compared to the 2,6-diacylpyridine series, indicating that steric hindrance and unfavorable hydrogen bonding interaction of the spacers might influence the observed reactivity differences. The 3,5-diacylpyridines were converted to the N-methylpyridinium salts and selected members of both neutral and cationic 3,5-diacylpyridinium derivatives were submitted to hydrogelations with synthetic polymer poly(1-glycidylpiperazine) via aza-Michael addition and thiolated natural hyaluronan via thio-Michael reaction, respectively. Rheological properties of the resulting hydrogels were studied, revealing that both spacer type as well as charge affected elastic moduli and degree of swelling.

  DOI：

  10.1055/s-0033-1338614
• 作为产物：
  描述：

  tert-butyl (4-acrylamidobutyl)carbamate 在 盐酸 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以79%的产率得到N-acryloyl-1,4-diaminobutane hydrochloride
  参考文献：
  名称：

  Synthesis of Pyridine Acrylates and Acrylamides and Their Corresponding Pyridinium Ions as Versatile Cross-Linkers for Tunable Hydrogels

  摘要：

  A small library of cross-linkers for hydrogels was synthesized. The cross-linkers consisted of 2,6- and 3,5-diacylpyridine or 2,4,6-triacylpyridine as the core unit, which were tethered via ethylene glycol, amino ethanol, and 1,n-diamine spacers to terminal acrylate or acrylamide moieties. Esterification and amide formation of the terminal acryl units were found to be dependent on the ratio of NH/O in the spacer, the constitution pattern of the pyridine ring, and the total number of acryl groups. Thus, esters generally gave higher yields than amides decreasing with increasing number of NH in the spacer and with increasing number of acryl units. In the case of 3,5-diacylpyridine derivatives, these trends were less prominent as compared to the 2,6-diacylpyridine series, indicating that steric hindrance and unfavorable hydrogen bonding interaction of the spacers might influence the observed reactivity differences. The 3,5-diacylpyridines were converted to the N-methylpyridinium salts and selected members of both neutral and cationic 3,5-diacylpyridinium derivatives were submitted to hydrogelations with synthetic polymer poly(1-glycidylpiperazine) via aza-Michael addition and thiolated natural hyaluronan via thio-Michael reaction, respectively. Rheological properties of the resulting hydrogels were studied, revealing that both spacer type as well as charge affected elastic moduli and degree of swelling.

  DOI：

  10.1055/s-0033-1338614

文献信息

• Hyperbranched cationic mussel-imitated polymer and method of preparing the same
  申请人：Sichuan Huili Industry Co., Ltd.

  公开号：US10703835B2

  公开（公告）日：2020-07-07

  The present invention discloses a hyperbranched cationic mussel-imitated polymer and a method of preparing the same. The hyperbranched polymer disclosed in the present invention has the excellent mussel-imitated non-selective adhesive property, good biocompatibility and adhesive strength adjustability. The method of the present invention includes the following steps: (A) adding an initiator, a RAFT agent and a first reaction mixture to a vessel containing DMF to form a second reaction mixture; (B) stirring the second reaction mixture until homogenous, and introducing argon to a reaction system to remove oxygen in the reaction system; (C) heating and stirring the second reaction mixture to carry out a reaction; (D) after a product with a desired molecular weight being produced, the reaction system being exposed to air and cooled rapidly in a cold water bath to terminate the reaction; and (E) purifying the product to obtain the hyperbranched cationic mussel-imitated polymer.

  本发明公开了一种超支化阳离子仿贻贝聚合物及其制备方法。本发明公开的超支化聚合物具有优异的仿贻贝非选择性粘合性能、良好的生物相容性和粘合强度可调性。本发明的方法包括以下步骤：(A) 在装有 DMF 的容器中加入引发剂、RAFT 剂和第一反应混合物，形成第二反应混合物； (B) 搅拌第二反应混合物直至均匀，并将氩气引入反应体系，以除去反应体系中的氧气；(C) 加热并搅拌第二反应混合物以进行反应； (D) 在生成所需分子量的产物后，将反应体系暴露在空气中并在冷水浴中快速冷却以终止反应；以及 (E) 净化产物以获得超支化阳离子贻贝模拟聚合物。
• Film for medicine packaging and method of preparing the same
  申请人：Sichuan Huili Industry Co., Ltd.

  公开号：US10703080B2

  公开（公告）日：2020-07-07

  The present invention discloses a film for a medicine packaging and a method of preparing the same. The film for the medicine packaging includes a polymer film layer, a graphene composite layer and a light-curable adhesive, wherein the polymer film layer is bonded with a graphene composite layer by a light-curable adhesive, the graphene composite layer includes multiple graphene layers bonded by the light-curable adhesive; and the light-curable adhesive includes a hyperbranched cationic mussel-imitated polymer including a multi-hydroxylbenzoylbenzamide ene amide monomer, a cationic monomer and a photo-responsive monomer. The present invention provides strong adhesion with reduced adhesive layer, allowing greatly increasing the number of the graphene layers in the graphene composite layer without obvious increase in the total thickness and mass. This can meet the requirements of the medicine packaging material, as it obviously lowers the film's permeation to water vapor and oxygen and significantly enhances the tensile strength.

  本发明公开了一种药品包装用薄膜及其制备方法。该药品包装用薄膜包括聚合物薄膜层、石墨烯复合层和光固化粘合剂，其中聚合物薄膜层通过光固化粘合剂与石墨烯复合层粘合，石墨烯复合层包括通过光固化粘合剂粘合的多个石墨烯层；光固化粘合剂包括超支化阳离子贻贝仿生聚合物，其中包括多羟基苯甲酰苯甲酰胺烯酰胺单体、阳离子单体和光响应性单体。本发明在减少粘合层的情况下，粘合力强，可以在不明显增加总厚度和质量的情况下，大大增加石墨烯复合材料层中石墨烯的层数。这样可以明显降低薄膜对水蒸气和氧气的渗透性，显著提高拉伸强度，从而满足药品包装材料的要求。
• WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF
  申请人：Novartis AG

  公开号：EP2625218A1

  公开（公告）日：2013-08-14
• FILM FOR MEDICINE PACKAGING AND METHOD OF PREPARING THE SAME
  申请人：Sichuan Huili Industry Co., Ltd.

  公开号：US20200070485A1

  公开（公告）日：2020-03-05

  The present invention discloses a film for a medicine packaging and a method of preparing the same. The film for the medicine packaging comprises a polymer film layer, a graphene composite layer and a light-curable adhesive, wherein the polymer film layer is bonded with a graphene composite layer by a light-curable adhesive, the graphene composite layer comprises multiple graphene layers bonded by the light-curable adhesive; and the light-curable adhesive comprises a hyperbranched cationic mussel-imitated polymer comprising a multi-hydroxylbenzoylbenzamide ene amide monomer, a cationic monomer and a photo-responsive monomer. The present invention provides strong adhesion with reduced adhesive layer, allowing greatly increasing the number of the graphene layers in the graphene composite layer without obvious increase in the total thickness and mass. This can meet the requirements of the medicine packaging material, as it obviously lowers the film's permeation to water vapor and oxygen and significantly enhances the tensile strength.
• HYPERBRANCHED CATIONIC MUSSEL-IMITATED POLYMER AND METHOD OF PREPARING THE SAME
  申请人：Sichuan Huili Industry Co., Ltd.

  公开号：US20200071433A1

  公开（公告）日：2020-03-05

  The present invention discloses a hyperbranched cationic mussel-imitated polymer and a method of preparing the same. The hyperbranched polymer disclosed in the present invention has the excellent mussel-imitated non-selective adhesive property, good biocompatibility and adhesive strength adjustability. The method of the present invention comprises the following steps: (A) adding an initiator, a RAFT agent and a first reaction mixture to a vessel containing DMF to form a second reaction mixture; (B) stirring the second reaction mixture until homogenous, and introducing argon to a reaction system to remove oxygen in the reaction system; (C) heating and stirring the second reaction mixture to carry out a reaction; (D) after a product with a desired molecular weight being produced, the reaction system being exposed to air and cooled rapidly in a cold water bath to terminate the reaction; and (E) purifying the product to obtain the hyperbranched cationic mussel-imitated polymer.