MNR6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: MNR6
• 英文别名: (1S,7R)-8-azabicyclo[5.2.0]nona-2,4-dien-9-one
• 化学式: C₈H₉NO
• 分子量: 135.166
• InChiKey: BBFFKJZDHLADAC-NKWVEPMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  溴甲苯 、 MNR6 在 sodium hydroxide 、 四丁基硫酸氢铵 作用下， 以 二氯甲烷 为溶剂， 生成 MNR5
  参考文献：
  名称：

  Design, synthesis and biological evaluation of novel bicyclic β-lactams as potential antimalarials

  摘要：

  A series of bicyclic N-substituted and unsubstituted beta-lactams were synthesized and evaluated as targeted potential antimalarials. The compounds MNR4 and MNR5 were found to have highest potency against Plasmodium falciparum in vitro. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.011
• 作为产物：
  描述：

  环庚三烯 在 sodium sulfite 作用下， 以 甲苯 为溶剂， 反应 13.0h， 生成 MNR6
  参考文献：
  名称：

  Design, synthesis and biological evaluation of novel bicyclic β-lactams as potential antimalarials

  摘要：

  A series of bicyclic N-substituted and unsubstituted beta-lactams were synthesized and evaluated as targeted potential antimalarials. The compounds MNR4 and MNR5 were found to have highest potency against Plasmodium falciparum in vitro. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.011

文献信息

• Design, synthesis and biological evaluation of novel bicyclic β-lactams as potential antimalarials
  作者：Manisha Nivsarkar、D. Thavaselvam、S. Prasanna、Mamta Sharma、M.P. Kaushik

  DOI：10.1016/j.bmcl.2005.01.011

  日期：2005.3

  A series of bicyclic N-substituted and unsubstituted beta-lactams were synthesized and evaluated as targeted potential antimalarials. The compounds MNR4 and MNR5 were found to have highest potency against Plasmodium falciparum in vitro. (c) 2005 Elsevier Ltd. All rights reserved.