(+/-)-3-(4-phenylphenyloxy)-1-aza-bicyclo[2.2.2]octane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+/-)-3-(4-phenylphenyloxy)-1-aza-bicyclo[2.2.2]octane
• 英文别名: 3-(biphenyl-4-yloxy)-1-aza-bicyclo[2.2.2]octane；3-(4-Phenylphenoxy)-1-azabicyclo[2.2.2]octane
• 化学式: C₁₉H₂₁NO
• 分子量: 279.382
• InChiKey: BCIOGGPNGDFPBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-[(4'-iodo-1,1'-biphenyl-4-yl)oxy]quinuclidine 、 N-甲基苄胺 在 tris-(dibenzylideneacetone)dipalladium(0) 、 bis(tri-tert-butylphosphine)dipalladium⁽⁰⁾ sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 15.0h， 以50%的产率得到N-[4'-(1-azabicyclo[2.2.2]oct-3-yloxy)-1,1'-biphenyl-4-yl]-N-benzyl-N-methylamine
  参考文献：
  名称：

  3-Quinuclidinyl amino-substituted biaryl derivatives

  摘要：

  式（I）的化合物 其中A为N或N + —O − ；n为0、1或2；Y为O、S、—NH—和—N-烷基-；Ar 1 为两个6-成员芳香环；Ar 2 为含有—NR 8 R 9 基团的5-或6-成员芳香环，如本文所定义。这些化合物在治疗α7 nAChR配体预防或改善的病症或疾病中很有用。还公开了含有式（I）化合物的药物组合物以及使用这些化合物和组合物的方法。

  公开号：

  US20050159597A1
• 作为试剂：
  描述：

  3-[(4'-iodo-1,1'-biphenyl-4-yl)oxy]quinuclidine 、 N-甲基苄胺 、 、 sodium t-butanolate 在 (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one;palladium 氮气 、 Brine 、 title compound 、 SiO2 、 二氯甲烷 、 甲醇 、 ammonium hydroxide 、 (+/-)-3-(4-phenylphenyloxy)-1-aza-bicyclo[2.2.2]octane 作用下， 以 甲苯 、 乙酸乙酯 为溶剂， 反应 15.0h， 生成 N-[4'-(1-azabicyclo[2.2.2]oct-3-yloxy)-1,1'-biphenyl-4-yl]-N-benzyl-N-methylamine
  参考文献：
  名称：

  3-quinuclidinyl amino-substituted biaryl derivatives

  摘要：

  式(I)的化合物，其中n为0、1或2；Y为O、S、—NH—和—N-烷基-；Ar1为6成员的芳香环；Ar2为带有—NR8R9基团的5或6成员的芳香环，如本文所定义。这些化合物在治疗α7 nAChR配体预防或改善的病症或疾病中有用。此外，还披露了含有式(I)化合物的制药组合物以及使用这种化合物和组合物的方法。

  公开号：

  US20050137203A1

文献信息

• [EN] NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE<br/>[FR] NOUVEAUX DERIVES QUINUCLIDINIQUES ET LEUR UTILISATION
  申请人：NEUROSEARCH AS

  公开号：WO2004016608A1

  公开（公告）日：2004-02-26

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  该发明涉及新型喹诺啉衍生物及其作为药物的用途。由于其药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱系统、外周神经系统（PNS）、平滑肌收缩、内分泌疾病、神经退行性疾病、炎症、疼痛以及由于滥用化学物质终止而引起的戒断症状等疾病或疾病有用。
• Novel quinuclidine derivatives and their use
  申请人：Peters Dan

  公开号：US20050245567A1

  公开（公告）日：2005-11-03

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的莨菪碱衍生物及其作为药物的使用。由于它们的药理特性，本发明中的化合物可能对治疗与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统有关的疾病或疾患、与平滑肌收缩有关的疾病或疾患、内分泌疾病或疾患、神经退行性疾病或疾患、与炎症、疼痛有关的疾病或疾患以及因化学物质滥用终止而引起的戒断症状可能有用。
• NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE
  申请人：PETERS Dan

  公开号：US20090005390A1

  公开（公告）日：2009-01-01

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的蒽环啶衍生物及其作为药物的用途。由于它们的药理特性，本发明中的化合物可能对多种与中枢神经系统（CNS）、外周神经系统（PNS）、平滑肌收缩有关的疾病或紊乱，内分泌疾病或紊乱，神经退行性疾病或紊乱，炎症、疼痛以及由于滥用化学物质而导致的戒断症状等疾病或紊乱有用。
• 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES
  申请人：Ji Jianguo

  公开号：US20070275975A1

  公开（公告）日：2007-11-29

  Compounds of formula (I) wherein A is N or N + —O − ; n is 0, 1, or 2; Y is O, S, —NH—, and —N-alkyl-; Ar 1 is both 6-membered aromatic rings; Ar 2 is 5- or 6-membered aromatic rings with a —NR 8 R 9 group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

  式(I)的化合物中，其中A为N或N+—O−; n为0、1或2; Y为O、S、—NH—和—N-烷基-; Ar1为两个6元芳香环; Ar2为带有—NR8R9基团的5-或6元芳香环，如本文所定义。这些化合物可用于治疗α7 nAChR配体预防或改善的疾病或症状。还公开了含有式(I)化合物的药物组合物以及使用这些化合物和组合物的方法。
• Quinuclidine derivatives and their use
  申请人：NEUROSEARCH A/S

  公开号：EP1905771A2

  公开（公告）日：2008-04-02

  This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型奎宁环衍生物及其药物用途。由于其药理特性，本发明的化合物可用于治疗各种疾病或失调，如与中枢神经系统（CNS）胆碱能系统、周围神经系统（PNS）、平滑肌收缩相关的疾病或失调、内分泌疾病或失调、神经变性相关的疾病或失调、炎症相关的疾病或失调、疼痛以及终止滥用化学物质引起的戒断症状。