1,4-bis-(1-(2-ethylhexyl))-phenylene carbonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-bis-(1-(2-ethylhexyl))-phenylene carbonate
• 英文别名: [4-(2-Ethylhexoxycarbonyloxy)phenyl] 2-ethylhexyl carbonate
• 化学式: C₂₄H₃₈O₆
• 分子量: 422.562
• InChiKey: BETDAAIIRFJBTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  30
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  氯甲酸-2-乙基己酯 、 对苯二酚 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 乙酸乙酯 为溶剂， 反应 24.0h， 以71%的产率得到1,4-bis-(1-(2-ethylhexyl))-phenylene carbonate
  参考文献：
  名称：

  Skin-depigmenting prodrugs of hydroquinone

  摘要：

  Novel mono-1 and bis-carbonates 2, and mono-3 and bis-pivaloyloxymethyl ethers 4 (bis-POM-ethers) of hydroquinone (HQ) evaluated as skin-lightening agents, showed that: 1) they cause an initial depigmentation of the skin; 2) the depigmenting effect is not maintained over prolonged periods of time; and 3) prolonged use results in a shift of the chromatic locus, suggesting the formation of a new chemical product in the skin. HQ was a more potent depigmenting agent than any of the derivatives tested.

  DOI：

  10.1016/0223-5234(93)90008-3

文献信息

• Skin-depigmenting prodrugs of hydroquinone
  作者：A Nudelman、Z Ben-Ishai、M Ruse、J Schamroth

  DOI：10.1016/0223-5234(93)90008-3

  日期：1993.1

  Novel mono-1 and bis-carbonates 2, and mono-3 and bis-pivaloyloxymethyl ethers 4 (bis-POM-ethers) of hydroquinone (HQ) evaluated as skin-lightening agents, showed that: 1) they cause an initial depigmentation of the skin; 2) the depigmenting effect is not maintained over prolonged periods of time; and 3) prolonged use results in a shift of the chromatic locus, suggesting the formation of a new chemical product in the skin. HQ was a more potent depigmenting agent than any of the derivatives tested.