(2'R)-7-hydroxy-8-(2',3'-dihydroxy-3'-methylbutyl)-coumarin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: (2'R)-7-hydroxy-8-(2',3'-dihydroxy-3'-methylbutyl)-coumarin
• 英文别名: (2'R)-7-hydroxy-8-(2',3'-dihydroxy-3'-methylbutyl)coumarin；8-[(2R)-2,3-dihydroxy-3-methylbutyl]-7-hydroxychromen-2-one
• 化学式: C₁₄H₁₆O₅
• 分子量: 264.278
• InChiKey: BFYOVPHBKUQKPM-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2'R)-7-hydroxy-8-(2',3'-dihydroxy-3'-methylbutyl)-coumarin 、 乙酸酐 生成 [8-[(2R)-2-acetyloxy-3-hydroxy-3-methylbutyl]-2-oxochromen-7-yl] acetate
  参考文献：
  名称：

  CECCHERELLI, PAOLO;CURINI, MASSIMO;MARCOTULLIO, MARIA CARLA;MADRUZZA, GIA+, J. NATUR. PROD., 52,(1989) N, C. 888-890

  摘要：

  DOI：
• 作为产物：
  描述：

  Tortuoside 生成 (2'R)-7-hydroxy-8-(2',3'-dihydroxy-3'-methylbutyl)-coumarin
  参考文献：
  名称：

  CECCHERELLI, PAOLO;CURINI, MASSIMO;MARCOTULLIO, MARIA CARLA;MADRUZZA, GIA+, J. NATUR. PROD., 52,(1989) N, C. 888-890

  摘要：

  DOI：

文献信息

• Highly enantioselective synthesis of angelmarin
  作者：Hang Jiang、Yasumasa Hamada

  DOI：10.1039/b913400j

  日期：——

  Angelmarin (1), a novel anti-cancer agent, was efficiently synthesized through a highly enantioselective epoxidation and a copper cyanide-mediated esterification of the hindered alcohol as the key steps in 53% overall yield.

  Angelmarin（1），一种新型抗癌剂，通过高度对映选择性的环氧化反应和铜氰化物介导的受阻醇酯化反应，作为关键步骤以53%的总产率高效合成。
• Monoterpene, chromone and coumarin glucosides of Diplolophium buchananii
  作者：John Lemmich

  DOI：10.1016/0031-9422(94)00599-o

  日期：1995.1

  Abstract A glycosidic fraction obtained from aerial parts of Diplolophium buchananii ssp. swynnertonii afforded 12 glucosides, of which three, or possibly four, are new. Thus, the main constituent is the new monoterpene, (1S,2R,4R,5S)- bornan-2,4,5-triol 2-O-β- d -glucopyranoside , the absolute configuration of which was determined by use of the exciton chirality rule. The chromone, (3S)-3,4- dihydro-5-methoxy

  摘要 从 Diplolophium buchananii ssp 地上部分获得的糖苷级分。swynnertonii 提供了 12 种糖苷，其中 3 种，也可能是 4 种是新的。因此，主要成分是新的单萜，(1S,2R,4R,5S)-bornan-2,4,5-triol 2-O-β-d-glucopyranoside，其绝对构型是通过使用激子手性规则。色酮、(3S)-3,4-二氢-5-甲氧基-3-β-d-吡喃葡萄糖氧基-2,2,8-三甲基-2H、10H-苯并[1,2-b:3,4-b ']dipyran-10-one 或 (2' S )-2'-hydroxy-7-O-methylallopeucenin 2'-O-β-d-glupyranoside 是新的。香豆素也是如此，(2 R )-2'-hydroxymarmesin 2'-O-β-d-吡喃葡萄糖苷，在 C-1' 具有未知构型。(2' R )-7-Hydroxy-8-(2
• Studies of Coumarins from the Chinese Drug Qianhu, XXVII: Structure of a New Simple Coumarin Glycoside from Bai-Hua Qianhu, Peucedanum praeruptorum
  作者：Hirotaka Ishii、Yoshihito Okada、Masaki Baba、Toru Okuyama

  DOI：10.1248/cpb.56.1349

  日期：——

  A new simple coumarin glycoside, named praeroside VI (1), along with six known coumarins, were isolated from an aqueous extract of Bai-Hua Qianhu, the root of Peucedanum praeruptorum DUNN. (Umbelliferae). Spectroscopic analysis and chemical studies were carried out to investigate the structure of the new coumarin, which was concluded to be 1. Additionally, two simple glycosidic coumarins and four simple

  从白花前胡DUNN的根源白花前胡的水提物中分离出一种新的简单香豆素苷，命名为praeroside VI（1），以及六种已知的香豆素。（伞形科）。进行了光谱分析和化学研究，以调查新香豆素的结构，得出结论为1。此外，鉴定出两个简单的糖苷香豆素和四个简单的非糖苷香豆素，分别为apiosylskimmin（2），hymexelsin（3），umbelliferone（ 4），胆碱（5），异fraxidin（6）和8-羧基-7-羟基香豆素（7）。这是首次报道将化合物7鉴定为植物材料的成分。
• CECCHERELLI, PAOLO;CURINI, MASSIMO;MARCOTULLIO, MARIA CARLA;MADRUZZA, GIA+, J. NATUR. PROD., 52,(1989) N, C. 888-890
  作者：CECCHERELLI, PAOLO、CURINI, MASSIMO、MARCOTULLIO, MARIA CARLA、MADRUZZA, GIA+

  DOI：——

  日期：——
• CECCHERELLI, PAOLO;CURINI, MASSIMO;MARCOTULLIO, MARIA CARLA;MADRUZZA, GIA+, J. NATUR. PROD., 53,(1990) N, C. 536-538
  作者：CECCHERELLI, PAOLO、CURINI, MASSIMO、MARCOTULLIO, MARIA CARLA、MADRUZZA, GIA+

  DOI：——

  日期：——