丙烯酸-2,3-环氧丙酯 | 51554-07-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 丙烯酸-2,3-环氧丙酯
• 中文别名: 亚油酸缩水甘油酯；亚麻酸缩水甘油酯
• 英文名称: linolenic acid glycidyl ester
• 英文别名: glycidol linolenate；glycidyl linolenate；Glycidyl；oxiran-2-ylmethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
• CAS: 51554-07-5
• 化学式: C₂₁H₃₄O₃
• 分子量: 334.499
• InChiKey: SGFJJNBUMXQSMU-PDBXOOCHSA-N

物化性质

• 沸点：
  430.9±33.0 °C(Predicted)
• 密度：
  0.964±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Γ-十八碳三烯酸 、 缩水甘油 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以19%的产率得到丙烯酸-2,3-环氧丙酯
  参考文献：
  名称：

  Structure−Activity Relationship of a Series of Inhibitors of Monoacylglycerol HydrolysisComparison with Effects upon Fatty Acid Amide Hydrolase

  摘要：

  A series of 32 heterocyclic analogues based on the structure of 2-arachidonoylglycerol (2-AG) were synthesized and tested for their ability to inhibit monoacylglycerol lipase and fatty acid an-tide hydrolase activities. The designed compounds feature a hydrophobic moiety and different heterocyclic subunits that mimic the glycerol fragment. This series has allowed us to carry out the first systematic structure activity relationship study on inhibition of 2-AG hydrolysis. The most promising compounds were oxiran-2-ylmethyl (5Z,8Z,l 11Z,14Z)-icosa-5,8,11,14-tetraenoate (1) and tetrahydro-2H-pyran-2-ylmethyl (5Z,8Z,11Z,14z)-icosa5,8,11,14-tetraenoate (5). They inhibited cytosolic 2-oleoylglycerol (2-OG) hydrolysis completely (IC50 values of 4.5 and 5.6 mu M, respectively). They also blocked, albeit less potently, 2-OG hydrolysis in membrane fractions (IC50 values of 19 and 26,mu M, respectively) and anandamide hydrolysis (IC50 values of 12 and 51 mu M, respectively). These compounds will be useful in delineating the importance of the cytosolic hydrolytic activity in the regulation of 2-AG levels and, hence, its potential as a target for drug development.

  DOI：

  10.1021/jm070642y

文献信息

• RESIN COMPOSITION AND MOLDED ARTICLE FILM AND FIBER EACH COMPRISING THE SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1445282A1

  公开（公告）日：2004-08-11

  Disclosed are a resin composition comprising a polylactic acid resin and a polyacetal resin, and such a resin composition in which the polylactic acid resin and the polyacetal resin are kept miscible with each other. The resin composition has good moldability, workability, mechanical properties, heat resistance and transparency, and may be worked into moldings, films and fibers for practical use.

  本发明公开了一种由聚乳酸树脂和聚缩醛树脂组成的树脂组合物，以及聚乳酸树脂和聚缩醛树脂保持互溶的树脂组合物。该树脂组合物具有良好的成型性、加工性、机械性能、耐热性和透明性，可加工成模塑件、薄膜和纤维以供实际使用。
• RESIN COMPOSITION AND MOLDED ARTICLE COMPRISING THE SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1792941A1

  公开（公告）日：2007-06-06

  A resin composition in which a polylactic acid resin (A) 95-5 wt%, an aromatic polycarbonate resin (B) 5-95 wt%, and, with respect to 100 wt parts of the total of the (A) and the (B), at least one compatibilizer selected from a polymer compound containing an acrylic resin or styrene resin unit as a graft (C), a polymer compound to which a glycidyl compound or an acid anhydride is grafted or copolymerized (D) and an oxazoline compound, an oxazine compound and a carbodiimide compound (E) are compounded.

  一种树脂组合物，其中聚乳酸树脂（A）占 95-5wt%，芳香族聚碳酸酯树脂（B）占 5-95wt%，相对于（A）和（B）总量的 100 重量份，至少一种相容剂选自含有丙烯酸树脂或苯乙烯树脂单元作为接枝物的聚合物化合物（C）、接枝或共聚缩水甘油化合物或酸酐的聚合物化合物 (D) 以及噁唑啉化合物、噁嗪化合物和碳化二亚胺化合物 (E)。
• THERMOPLASTIC RESIN COMPOSITION AND MOLDED ARTICLE THEREOF
  申请人：Toray Industries, Inc.

  公开号：EP2036952A1

  公开（公告）日：2009-03-18

  This invention relates to a thermoplastic resin composition and a molded article thereof, respectively excellent in flowability and mechanical properties, and, in a preferred mode, also excellent in low warping property, laser transmittance and laser weldability, and provides a thermoplastic resin composition obtained by mixing (B) 0.1 to 4 parts by weight of a polyfunctional compound having three or more functional groups, in which at least one of the terminal structures having the functional groups is a structure containing alkylene oxide units, with (A) 100 parts by weight of a thermoplastic resin, and further provides a molded particle thereof. It is preferred that the (A) thermoplastic resin is one or more selected from a polyester resin and polycarbonate resin.

  本发明涉及一种热塑性树脂组合物及其模塑制品，它们分别具有优异的流动性和机械性能，在优选模式下，还具有优异的低翘曲性能、激光透射率和激光可焊性，本发明提供了一种热塑性树脂组合物，该组合物是将(B)0.1 至 4 份（按重量计）具有三个或三个以上官能团的多官能团化合物与(A)100 份（按重量计）热塑性树脂混合而得，其中具有官能团的末端结构中至少有一个是含有环氧亚烷基单元的结构，本发明还进一步提供了其模塑颗粒。优选的是，(A) 热塑性树脂是从聚酯树脂和聚碳酸酯树脂中选出的一种或多种。
• POLYLACTIC ACID COMPOSITION
  申请人：Teijin Limited

  公开号：EP2116576A1

  公开（公告）日：2009-11-11

  It is an object of the present invention to provide a polylactic acid composition having excellent crystallinity, wet heat stability and melt stability. It is another object of the present invention to provide a molded article which is obtained from the polylactic acid composition and excellent in appearance and color. The present invention is a composition and molded article thereof which comprises a polylactic acid (component A), a carbodiimide compound (component B) and a phosphoric acid ester metal salt (component C).

  本发明的一个目的是提供一种具有优异结晶度、湿热稳定性和熔融稳定性的聚乳酸组合物。本发明的另一个目的是提供一种由该聚乳酸组合物制成的模塑制品，其外观和色泽极佳。 本发明是一种由聚乳酸（A 组分）、碳化二亚胺化合物（B 组分）和磷酸酯金属盐（C 组分）组成的组合物及其成型品。
• POLYLACTIC ACID FILM
  申请人：Teijin Limited

  公开号：EP2330148A1

  公开（公告）日：2011-06-08

  A polylactic acid film having excellent transparency and capable of retaining high transparency even when it is exposed to a high temperature. The polylactic acid film is obtained by melt extruding polylactic acid (A) prepared by melt kneading together polylactic acid (B) which comprises an L-lactic acid unit as the main ingredient and polylactic acid (C) which comprises a D-lactic acid unit as the main ingredient in a specific weight ratio, wherein the polylactic acid film has (a) a stereocomplex crystal rate (S) defined by the following equation (i) of 90 % or more: S=(ΔHmsc/ΔHmsc+ΔHmhx100 (in the above equation, ΔHmh is the melting enthalpy of a low-melting point crystal melting peak at a temperature lower than 190°C obtained by differential scanning calorimeter (DSC) measurement and ΔHmsc is the melting enthalpy of a high-melting point crystal melting peak at a temperature of 190°C or higher obtained by DSC measurement), (b) a haze of 10 % or less, and (c) a haze change of 5 % or less after it is heated at 140°C for 10 minutes.

  一种透明度极佳的聚乳酸薄膜，即使在高温下也能保持高透明度。 该聚乳酸薄膜是通过熔融挤压聚乳酸（A）制备的，聚乳酸（A）是由以 L-乳酸单元为主要成分的聚乳酸（B）和以 D-乳酸单元为主要成分的聚乳酸（C）按特定重量比熔融捏合而成，其中 (a) 聚乳酸薄膜的立体复合晶体率 (S) 由下式(i)定义为 90% 或以上：S=(ΔHmsc/ΔHmsc+ΔHmhx100 (在上式中，ΔHmh 是通过差示扫描量热仪（DSC）测量获得的温度低于 190°C 的低熔点晶体熔峰的熔化焓，ΔHmsc 是通过差示扫描量热仪测量获得的温度在 190°C 或以上的高熔点晶体熔峰的熔化焓）、 (b) 雾度不超过 10%，以及 (c) 在 140°C 下加热 10 分钟后，雾度变化不超过 5%。