6-{[(3'-ethoxybiphenyl-4-ylmethyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-{[(3'-ethoxybiphenyl-4-ylmethyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid
• 英文别名: {6-[(3'-ethoxybiphenyl-4-ylmethyl)(pyridine-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid；{6-[N-(3'-ethoxybiphenyl-4-ylmethyl)(pyridin-2-ylsulfonyl)aminomethyl]-pyridin-2-ylamino}acetic acid；US9676720, Example 7；2-[[6-[[[4-(3-ethoxyphenyl)phenyl]methyl-pyridin-2-ylsulfonylamino]methyl]pyridin-2-yl]amino]acetic acid
• 化学式: C₂₈H₂₈N₄O₅S
• 分子量: 532.62
• InChiKey: BIMLHLJOXYCJQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  38
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  4-羟甲基苯硼酸 在 盐酸 、 四(三苯基膦)钯 、 三丁基膦 、 偶氮二甲酰胺 、 sodium carbonate 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醇 、 水 、 甲苯 为溶剂， 反应 9.0h， 生成 6-{[(3'-ethoxybiphenyl-4-ylmethyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid
  参考文献：
  名称：

  치환 비아릴 화합물

  摘要：

  This invention provides a substituted biaryl compound or a pharmaceutically acceptable salt thereof represented by the chemical formula (I) (wherein, R, W, R, and Z are as defined in the claims and specification) . The compounds of the present invention are useful as therapeutic agents and/or prophylactic agents for idiopathic pulmonary fibrosis and pulmonary fibrosis due to their excellent pulmonary fibroblast proliferation inhibitory activity.

  公开号：

  KR20150135460A

文献信息

• 치환 비아릴 화합물
  申请人：UBE Corporation 유비이 가부시키가이샤(519980963229)

  公开号：KR20150135460A

  公开（公告）日：2015-12-02

  본 발명은 화학식 (I) (화학식 중, R, W, R 및 Z는 특허청구범위 및 명세서에서 정의한 바와 같음)로 표현되는 치환 비아릴 화합물 또는 그의 약리상 허용되는 염을 제공한다. 본 발명의 화합물은 우수한 폐섬유 아세포 증식 억제 작용을 갖는 점에서, 간질성 폐렴·폐섬유증에 대한 치료약 및/또는 예방약으로서 유용하다.

  This invention provides a substituted biaryl compound or a pharmaceutically acceptable salt thereof represented by the chemical formula (I) (wherein, R, W, R, and Z are as defined in the claims and specification) . The compounds of the present invention are useful as therapeutic agents and/or prophylactic agents for idiopathic pulmonary fibrosis and pulmonary fibrosis due to their excellent pulmonary fibroblast proliferation inhibitory activity.
• PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF PULMONARY DISEASE
  申请人：UBE INDUSTRIES, LTD.

  公开号：US20160213657A1

  公开（公告）日：2016-07-28

  Provided is a pharmaceutical composition containing, as an active ingredient thereof, a substituted biaryl compound represented by general formula (I), wherein, R 1 , W, R 2 and Z are as defined in the claims and description, or a pharmacologically acceptable salt thereof. The pharmaceutical composition of the present invention is useful as a therapeutic drug and/or prophylactic drug for chronic obstructive pulmonary disease due to having an excellent anti-inflammatory effect.

  提供的是一种药物组合物，其活性成分是由一般式(I)表示的取代联苯化合物，其中R1、W、R2和Z如权利要求和描述中所定义，或其药理学上可接受的盐。本发明的药物组合物由于具有出色的抗炎效果，可用作治疗慢性阻塞性肺病的治疗药物和/或预防药物。
• US9676720B2
  申请人：——

  公开号：US9676720B2

  公开（公告）日：2017-06-13
• SUBSTITUTED BIARYL COMPOUND
  申请人：UBE Industries, Ltd.

  公开号：EP2980075A1

  公开（公告）日：2016-02-03

  The present invention provides a substituted biaryl compound of general formula (I): wherein, R1, W, R2, and Z are as defined in the claims and the description, or a pharmacologically acceptable salt thereof. The compound according to the present invention has an excellent inhibition effect of pulmonary fibroblast proliferation, and is therefore useful as a therapeutic agent and/or a prophylactic agent for interstitial pneumonia and pulmonary fibrosis.

  本发明提供了一种通式（I）的取代联苯化合物： 其中，R1、W、R2和Z如权利要求和描述中所定义，或其药理学上可接受的盐。根据本发明的化合物具有优异的抑制肺成纤维细胞增殖的效果，因此可用作间质性肺炎和肺纤维化的治疗剂和/或预防剂。