2-(2-iminoimidazolidin-1-yl)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-iminoimidazolidin-1-yl)propanoic acid
• 英文别名: 2-(2-Amino-4,5-dihydroimidazol-1-yl)propanoic acid
• 化学式: C₆H₁₁N₃O₂
• 分子量: 157.172
• InChiKey: BJZHHTYUSJPMOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙烯亚胺 、 溴化氰 、 L-丙氨酸 以 乙醚 为溶剂， 反应 2.0h， 生成 2-(2-iminoimidazolidin-1-yl)propanoic acid
  参考文献：
  名称：

  [EN] INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF
  [FR] INHIBITEURS DE TRANSPORT DE LA CRÉATINE ET LEURS UTILISATIONS

  摘要：

  这项发明涉及抑制肌酸转运和/或肌酸激酶的化合物，包括这种化合物的药物组合物，以及利用这种化合物和组合物治疗癌症的方法。

  公开号：

  WO2015168465A1

文献信息

• [EN] INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF<br/>[FR] INHIBITEURS DE TRANSPORT DE CRÉATINE ET LEURS UTILISATIONS
  申请人：RGENIX INC

  公开号：WO2016176636A1

  公开（公告）日：2016-11-03

  This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.

  这项发明涉及抑制肌酸转运和/或肌酸激酶的化合物，包括这些化合物的药物组合物，以及利用这些化合物和组合物治疗癌症的方法。
• Modified Creatine Compounds
  申请人：Gencia Corporation

  公开号：US20150005258A1

  公开（公告）日：2015-01-01

  The invention discloses creatine derivatives that are represented by Formula (I), Formula (II), and Formula (III); wherein Z is a functional group; Y is a mitochondrial targeting agent, a cationic ammonium group, or a polypeptide containing at least one positively charged amino acid residue; each R 1 is independently hydrogen, alkyl, or a phosphate group; R 2 a linker; R 3 is a spacer group; R 4 is hydrogen, alkyl, aryl, or heterocyclic; or R 4 and R 1 , or R 4 and R 3 , together with the nitrogen atoms to which they are attached form a heterocyclic ring, and W is hydrogen or alkyl.

  本发明公开了由式(I)、式(II)和式(III)表示的肌酸衍生物；其中Z是功能基团；Y是线粒体定位剂、阳离子铵基团或至少含有一个带正电氨基酸残基的多肽；每个R1独立地是氢、烷基或磷酸基团；R2是连接基；R3是间隔基团；R4是氢、烷基、芳基或杂环基；或者R4和R1，或者R4和R3，与它们连接的氮原子共同形成杂环环，W是氢或烷基。
• Compositions and Methods for Treating Conditions that Affect Epidermis
  申请人：GENCIA CORPORATION

  公开号：US20160022709A1

  公开（公告）日：2016-01-28

  The present invention relates to the compositions and methods for treating or alleviating conditions that affect the epidermis (e.g., wrinkles, sun damaged skin, symptoms of aged skin, or the like).

  本发明涉及用于治疗或缓解影响表皮的状况（例如皱纹、受阳光损伤的皮肤、老化皮肤的症状等）的组合物和方法。
• Use of creatine or creatine analogs for the tratment of diseases of the nervous system
  申请人：Avicena Group, Inc.

  公开号：EP1719510A1

  公开（公告）日：2006-11-08

  The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents against a variety of diseases of the nervous system such as diabetic and toxic neuropathies, peripheral nervous system diseases, Alzheimer disease, Parkinson's disease, stroke, Huntington's disease, motor neuron disease, traumatic nerve injury, multiple sclerosis, dysmyelination and demyelination disorders, and mitochondrial diseases. The Creatine compounds which can be used in the present method include: (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine; (3) creatine analogs which can act as reversible or irreversible inhibitors of creatine kinase, and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.

  本发明涉及肌酸化合物（包括肌酸、磷酸肌酸或肌酸类似物，如环肌酸）用于治疗神经系统疾病的用途。肌酸化合物可用作治疗各种神经系统疾病的有效药物，如糖尿病和中毒性神经病、周围神经系统疾病、阿尔茨海默病、帕金森病、中风、亨廷顿氏病、运动神经元疾病、创伤性神经损伤、多发性硬化症、髓鞘脱落和脱髓鞘疾病以及线粒体疾病。可用于本方法的肌酸化合物包括(1) 可作为肌酸激酶底物或底物类似物的肌酸、磷酸肌酸和这些化合物的类似物；(2) 肌酸激酶的双底物抑制剂，包括共价连接的三磷酸腺苷（ATP）和肌酸的结构类似物；(3) 可作为肌酸激酶可逆或不可逆抑制剂的肌酸类似物；以及 (4) 含有模拟 N-磷酸基的不可转移分子的 N-磷酸肌酸类似物。
• Use of creatine or creatine analogs for the treatment of diseases of the nervous system
  申请人：Avicena Group, Inc.

  公开号：EP2327404A1

  公开（公告）日：2011-06-01

  The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents against a variety of diseases of the nervous system such as diabetic and toxic neuropathies, peripheral nervous system diseases, Alzheimer disease, Parkinson's disease, stroke, Huntington's disease, motor neuron disease, traumatic nerve injury, multiple sclerosis, dysmyelination and demyelination disorders, and mitochondrial diseases. The Creatine compounds which can be used in the present method include: (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine; (3) creatine analogs which can act as reversible or irreversible inhibitors of creatine kinase, and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.

  本发明涉及肌酸化合物（包括肌酸、磷酸肌酸或肌酸类似物，如环肌酸）用于治疗神经系统疾病的用途。肌酸化合物可用作治疗各种神经系统疾病的有效药物，如糖尿病和中毒性神经病、周围神经系统疾病、阿尔茨海默病、帕金森病、中风、亨廷顿氏病、运动神经元疾病、创伤性神经损伤、多发性硬化症、髓鞘脱落和脱髓鞘疾病以及线粒体疾病。可用于本方法的肌酸化合物包括(1) 可作为肌酸激酶底物或底物类似物的肌酸、磷酸肌酸和这些化合物的类似物；(2) 肌酸激酶的双底物抑制剂，包括共价连接的三磷酸腺苷（ATP）和肌酸的结构类似物；(3) 可作为肌酸激酶可逆或不可逆抑制剂的肌酸类似物；以及 (4) 含有模拟 N-磷酸基的不可转移分子的 N-磷酸肌酸类似物。