dimethyl 1-(4-methoxyphenyl)-1,3-dihydro-2H-indene-2,2-dicarboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: dimethyl 1-(4-methoxyphenyl)-1,3-dihydro-2H-indene-2,2-dicarboxylate
• 英文别名: Dimethyl 1-(4-methoxyphenyl)-1,3-dihydroindene-2,2-dicarboxylate；dimethyl 1-(4-methoxyphenyl)-1,3-dihydroindene-2,2-dicarboxylate
• 化学式: C₂₀H₂₀O₅
• 分子量: 340.376
• InChiKey: BKISPBOBEFTVQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-碘苯甲基溴 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 7.33h， 生成 dimethyl 1-(4-methoxyphenyl)-1,3-dihydro-2H-indene-2,2-dicarboxylate
  参考文献：
  名称：

  Cyclization of η³-Benzylpalladium Intermediates Derived from Carbene Insertion

  摘要：

  Migratory insertion of benzylidene carbene ligands into arylpalladium(II) species generates η(3)-benzylpalladium intermediates that can cyclize to generate five- and six-membered rings with new sp(3) centers. The reaction tolerates a range of arene functional groups and stabilized enolates. The products generated through this reaction are 1-arylindanes and 1-aryltetralins that are common to a range of natural products.

  DOI：

  10.1021/ol502813u

文献信息

• Cyclization of η³-Benzylpalladium Intermediates Derived from Carbene Insertion
  作者：Eugene S. Gutman、Vanessa Arredondo、David L. Van Vranken

  DOI：10.1021/ol502813u

  日期：2014.10.17

  Migratory insertion of benzylidene carbene ligands into arylpalladium(II) species generates η(3)-benzylpalladium intermediates that can cyclize to generate five- and six-membered rings with new sp(3) centers. The reaction tolerates a range of arene functional groups and stabilized enolates. The products generated through this reaction are 1-arylindanes and 1-aryltetralins that are common to a range of natural products.