nor-isoerlangeafusciol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: nor-isoerlangeafusciol
• 英文别名: 2-(1-hydroxy-1-methylethyl)-2,3-dihydrofuro[3,2-c][1]benzopyran-2(3H)-one；2-(2-Hydroxypropan-2-yl)-2,3-dihydrofuro[3,2-c]chromen-4-one
• 化学式: C₁₄H₁₄O₄
• 分子量: 246.263
• InChiKey: BMYFPIXDSJUWPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  nor-isoerlangeafusciol 在 methoxycarbonylsulfamoyl-triethylammmonium hydroxide 作用下， 以 苯 为溶剂， 反应 0.5h， 以51%的产率得到nor-pterophyllin I
  参考文献：
  名称：

  A Straightforward Entry into Polyketide Monoprenylated Furanocoumarins and Pyranocoumarins

  摘要：

  A regioselective synthesis of 5-methyl- and 5-ethyl-4-hydroxycoumarin (Ib and Ic, respectively) is described. Starting from these compounds, several prenylated polyketide coumarins of limited availability from natural sources and important taxonomic relevance were prepared.

  DOI：

  10.1021/np990241o
• 作为产物：
  描述：

  4-羟基香豆素 、 2-甲基-3-丁烯-2-醇 在 ammonium cerium(IV) nitrate 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以51%的产率得到nor-isoerlangeafusciol
  参考文献：
  名称：

  A Straightforward Entry into Polyketide Monoprenylated Furanocoumarins and Pyranocoumarins

  摘要：

  A regioselective synthesis of 5-methyl- and 5-ethyl-4-hydroxycoumarin (Ib and Ic, respectively) is described. Starting from these compounds, several prenylated polyketide coumarins of limited availability from natural sources and important taxonomic relevance were prepared.

  DOI：

  10.1021/np990241o

文献信息

• A Straightforward Entry into Polyketide Monoprenylated Furanocoumarins and Pyranocoumarins
  作者：Giovanni Appendino、Giancarlo Cravotto、Giovanni B. Giovenzana、Giovanni Palmisano

  DOI：10.1021/np990241o

  日期：1999.12.1

  A regioselective synthesis of 5-methyl- and 5-ethyl-4-hydroxycoumarin (Ib and Ic, respectively) is described. Starting from these compounds, several prenylated polyketide coumarins of limited availability from natural sources and important taxonomic relevance were prepared.