4-methoxy-1-(2-methylcyclohexe-2-enyl)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-methoxy-1-(2-methylcyclohexe-2-enyl)benzene
• 英文别名: 1-Methoxy-4-(2-methylcyclohex-2-en-1-yl)benzene
• 化学式: C₁₄H₁₈O
• 分子量: 202.296
• InChiKey: BMYLSXLNMJNQOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲基-2-环己烯-1-醇 在 吡啶 、 indium(III) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 4-methoxy-1-(2-methylcyclohexe-2-enyl)benzene
  参考文献：
  名称：

  Efficient Palladium-Catalyzed Nucleophilic Addition of Triorganoindium Reagents to Carbocyclic Derivatives

  摘要：

  Palladium (0)-catalyzed allylic substitution reactions employing triorganoindium reagents have been investigated. In situ generated vinyl- and arylindiums react with substituted and unsubstituted cyclohex-2-enyl esters in the presence of 1-3 mol % Pd-2(dba)(3) to produce vinyl- or arylcyclohexenes in moderate to excellent yields. The stereoselectivity of this process was also examined, and evidence is presented that the reaction proceeds with inversion of stereochemical configuration.

  DOI：

  10.1021/jo0357162

文献信息

• Cu-Catalyzed Oxidative Allylic C–H Arylation of Inexpensive Alkenes with (Hetero)Aryl Boronic Acids
  作者：Suman Pal、Marine Cotard、Baptiste Gérardin、Christophe Hoarau、Cédric Schneider

  DOI：10.1021/acs.orglett.1c00812

  日期：2021.4.16

  oxidative allylic C(sp3)–H arylation by radical relay using a broad range of heteroaryl boronic acids with inexpensive and readily available unactivated terminal and internal olefins. This C(sp2)–C(sp3) allyl coupling has the advantage of using cheap, abundant, and nontoxic Cu2O without the need to use prefunctionalized alkenes, thus offering an alternative method to allylic arylation reactions that employ

  在本文中，我们介绍了使用广泛的杂芳基硼酸与廉价且易于获得的未活化末端和内部烯烃通过自由基中继进行的区域选择性Cu催化的氧化烯丙基C（sp 3）-H芳基化反应。这种C（sp 2）–C（sp 3）烯丙基偶联的优点是无需使用预官能化的烯烃即可使用廉价，丰富且无毒的Cu 2 O，从而为采用更传统偶联的烯丙基芳基化反应提供了另一种方法与预先安装的离队（LG）处于同盟位置的合作伙伴。
• Efficient Palladium-Catalyzed Nucleophilic Addition of Triorganoindium Reagents to Carbocyclic Derivatives
  作者：Lucas Baker、Thomas Minehan

  DOI：10.1021/jo0357162

  日期：2004.5.1

  Palladium (0)-catalyzed allylic substitution reactions employing triorganoindium reagents have been investigated. In situ generated vinyl- and arylindiums react with substituted and unsubstituted cyclohex-2-enyl esters in the presence of 1-3 mol % Pd-2(dba)(3) to produce vinyl- or arylcyclohexenes in moderate to excellent yields. The stereoselectivity of this process was also examined, and evidence is presented that the reaction proceeds with inversion of stereochemical configuration.