1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine
• 英文别名: 5,6,7,8-tetrahydropyrazino[2,3-b]pyrazine
• 化学式: C₆H₈N₄
• 分子量: 136.156
• InChiKey: BOIPKLGJDCZHIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3-二氨基哌嗪 、 乙二醇 在 十二羰基三钌 、 potassium tert-butylate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 2-甲基-2-丁醇 为溶剂， 反应 10.0h， 以80%的产率得到1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine
  参考文献：
  名称：

  环状转移氢化策略可直接获得四氢稠合吡嗪衍生物

  摘要：

  首次证明了钌催化的环状转移氢化策略，可直接从N-杂芳基二胺和邻二醇获得四氢稠合吡嗪衍生物。这样的综合进行...

  DOI：

  10.1039/c6cc05329g

文献信息

• 2,4-Diaminopyrimidine compounds useful as immunosuppressants
  申请人：——

  公开号：US20030191307A1

  公开（公告）日：2003-10-09

  Novel compounds according to the formula 1 and pharmaceutically acceptable salts, solvates, or hydrates thereof; wherein each occurrence of A is independently selected from CH or N; X is selected from the group consisting of —CH 2 —, —O—, —NH—, (C 1 -C 6 )alkylamino-, (C 1 -C 6 )alkylaminocarbonylamino-, (C 1 -C 6 )alkylcarbonylamino-, (C 1 -C 6 )alkylsulfonylamino-, phenylsulfonylamino-, carbonyl, —NH—C(O)—, —N(C 1 -C 6 )alkyl-C(O)—, —S(O) y — where y is 0, 1 or 2, and; n in —(CH 2 ) n — is 1, 2 or 3; and R 1 , R 2 , and R 3 are as described herein; pharmaceutical compositions that including these compounds, and methods for the treatment of autoimmune disease, inflammation, allergy, transplant rejection, and other circumstances where administration of an immunosuppressive agent is of therapeutic benefit.

  根据公式1及其药学上可接受的盐、溶剂或水合物，制备了新的化合物；其中A的每次出现独立地选自CH或N；X选自以下群体：—CH2—、—O—、—NH—、(C1-C6)烷基氨基、(C1-C6)烷基氨基甲酰氨基、(C1-C6)烷基羧酰氨基、(C1-C6)烷基磺酰氨基、苯基磺酰氨基、羰基、—NH—C(O)—、—N(C1-C6)烷基-C(O)—、—S(O)y—，其中y为0、1或2，而—(CH2)n—中的n为1、2或3；R1、R2和R3如本文所述；包括这些化合物的药物组合物，以及用于治疗自身免疫性疾病、炎症、过敏、移植排斥以及其他需要免疫抑制剂治疗的情况的方法。
• 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS
  申请人：Pfizer Products Inc.

  公开号：EP1242403B1

  公开（公告）日：2006-01-04
• Perovskite Material Layer Processing
  申请人：Irwin Michael D.

  公开号：US20150318477A1

  公开（公告）日：2015-11-05

  A method for processing a perovskite photoactive layer. The method comprises depositing a lead salt precursor onto a substrate to form a lead salt thin film, depositing a second salt precursor onto the lead salt thin film, annealing the substrate to form a perovskite material.
• METHODS AND COMPOSITIONS FOR INHIBITING OR REDUCING HAIR LOSS, ACNE, ROSACEA, PROSTATE CANCER, AND BPH
  申请人：The Trustees of the University of Pennsylvania

  公开号：US20160346186A1

  公开（公告）日：2016-12-01

  This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.
• US7101869B2
  申请人：——

  公开号：US7101869B2

  公开（公告）日：2006-09-05