hydroxy-dichlorobenzenesulfonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: hydroxy-dichlorobenzenesulfonic acid
• 英文别名: 3,4-Dichloro-2-hydroxybenzenesulfonic acid
• 化学式: C₆H₄Cl₂O₄S
• 分子量: 243.067
• InChiKey: BOUSMGITTRHFHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二氯-苯酚 在 硫酸 作用下， 以 水 为溶剂， 反应 2.78h， 以42%的产率得到2,3-dichlorophenol-4-sulfonic acid
  参考文献：
  名称：

  磺化和在氯-和二氯苯酚，3-氟苯酚和的硫酸化反应（2,3-，2,4-和3,4-二氯苯氧基）乙酸用浓硫酸和三氧化硫†往最‡ §

  摘要：

  氯和二氯苯酚已在非质子传递溶剂中用硫酸和SO 3磺化。在用浓硫酸水溶液进行磺化反应中，磺酸异构体的分布主要取决于羟基取代基的邻位和对位和活化作用。这也是使用不超过1.0当量的SO 3的非质子磺化反应的决定因素。当使用大量的SO 3时，磺化异构体的分布越来越多地通过相应的苯基硫酸氢盐的额外磺化来确定，其中-OSO 3 H取代基是失活的，主要是对-（进而邻）指挥。

  DOI：

  10.1002/recl.19881070303

文献信息

• EFFECTS OF APOLIPOPROTEIN B INHIBITION ON GENE EXPRESSION PROFILES IN ANIMALS
  申请人：GENZYME CORPORATION

  公开号：US20150232838A1

  公开（公告）日：2015-08-20

  Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided. Methods are provided for modulating the expression of genes involved in lipid metabolism, useful in the treatment of conditions associated with cardiovascular risk. Antisense oligonucleotides targeted to apolipoprotein B reduce the level of apolipoprotein B mRNA, lower serum cholesterol and shift liver gene expression profiles from those of an obese animal towards those of a lean animal. Further provided are methods for improving the cardiovascular risk of a subject through antisense inhibition of apolipoprotein B. Also provided are methods for employing antisense oligonucleotides targeted to apolipoprotein B to modulate a cellular pathway or metabolic process.

  提供了用于调节载脂蛋白B表达的反义物质、组合物和方法。这些组合物包括针对编码载脂蛋白B的核酸的反义物质，特别是反义寡核苷酸。提供了使用这些化合物调节载脂蛋白B表达并治疗与载脂蛋白B表达相关疾病的方法。提供了用于调节涉及脂质代谢的基因表达的方法，可用于治疗与心血管风险相关的疾病。针对载脂蛋白B的反义寡核苷酸降低了载脂蛋白B mRNA水平，降低了血清胆固醇水平，并将肝脏基因表达谱从肥胖动物的表达谱转变为瘦小动物的表达谱。此外，还提供了通过反义抑制载脂蛋白B来改善受试者心血管风险的方法。还提供了使用针对载脂蛋白B的反义寡核苷酸调节细胞通路或代谢过程的方法。
• Use of antisense oligonucleotide libraries for identifying gene function
  申请人：——

  公开号：US20030054354A1

  公开（公告）日：2003-03-20

  A method for identifying one or more genes involved in a phenotype of cells, tissues or organisms, comprising the steps of contacting cells, tissues or organisms which exhibit the phenotype with a library of antisense oligonucleotides and performing a primary phenotypic assay to determine which antisense oligonucleotides in the library attenuate the phenotype. These antisense oligonucleotides correspond to genes involved in the phenotype. The method may be used to identify genes involved in various disease states.

  一种用于识别与细胞、组织或生物体表型相关的一个或多个基因的方法，包括以下步骤：将显示该表型的细胞、组织或生物体与一个反义寡核苷酸文库接触，并进行主要表型分析以确定文库中哪些反义寡核苷酸减弱了该表型。这些反义寡核苷酸对应于参与表型的基因。该方法可用于识别参与各种疾病状态的基因。
• Effects of apolipoprotein B inhibition on gene expression profiles in animals
  申请人：Crooke M. Rosanne

  公开号：US20060009410A1

  公开（公告）日：2006-01-12

  Methods are provided for modulating the expression of genes involved in lipid metabolism, useful in the treatment of conditions associated with cardiovascular risk. Antisense oligonucleotides targeted to apolipoprotein B reduce the level of apolipoprotein B mRNA, lower serum cholesterol and shift liver gene expression profiles from those of an obese animal towards those of a lean animal. Further provided are methods for improving the cardiovascular risk of a subject through antisense inhibition of apolipoprotein B. Also provided are methods for employing antisense oligonucleotides targeted to apolipoprotein B to modulate a cellular pathway or metabolic process.

  提供了一种调节涉及脂质代谢基因表达的方法，该方法对于治疗与心血管风险相关的疾病非常有用。针对载脂蛋白B的反义寡核苷酸可以降低载脂蛋白B mRNA的水平，降低血清胆固醇并将肝脏基因表达谱从肥胖动物转向瘦小动物。此外，还提供了通过反义抑制载脂蛋白B来改善受试者心血管风险的方法。同时，还提供了使用针对载脂蛋白B的反义寡核苷酸来调节细胞通路或代谢过程的方法。
• USE OF ANTISENSE OLIGONUCLEOTIDE LIBRARIES FOR IDENTIFYING GENE FUNCTION
  申请人：Bennett C. Frank

  公开号：US20090023599A1

  公开（公告）日：2009-01-22

  A method for identifying one or more genes involved in a phenotype of cells, tissues or organisms, comprising the steps of contacting cells, tissues or organisms which exhibit the phenotype with a library of antisense oligonucleotides and performing a primary phenotypic assay to determine which antisense oligonucleotides in the library attenuate the phenotype. These antisense oligonucleotides correspond to genes involved in the phenotype. The method may be used to identify genes involved in various disease states.

  一种用于鉴定细胞、组织或生物体表现出的一个或多个表型所涉及的基因的方法，包括以下步骤：将表现出该表型的细胞、组织或生物体与反义寡核苷酸文库接触，并进行初级表型测定，以确定文库中哪些反义寡核苷酸减弱了该表型，这些反义寡核苷酸对应于参与该表型的基因。该方法可用于鉴定参与各种疾病状态的基因。
• Enzymatic high range glucose test
  申请人：MILES INC.

  公开号：EP0182225A2

  公开（公告）日：1986-05-28

  A test composition comprising glucose oxidase, a peroxidatively active component, a chromogenic indicator system capable of providing a detectable response and a borate buffer capable of providing an initial pH above about pH 7 is particularly useful for the semiquantitative determination of high range glucose, (i.e. glucose concentrations of 1,000 mg/dL to 10,000 mg/dL). A preferred indicator system is a water soluble iodide salt and poly-(vinylpyrrolidone). The use of a borate buffer capable of providing an initial pH above about pH 7 permits greatly improved resolution for the semiquantitative determination of high range glucose when the test composition is incorporated onto a carrier matrix to prepare a solid state unitary test device.

  由葡萄糖氧化酶、过氧化活性成分、能提供可检测反应的显色指示剂系统和能提供高于约 pH7 初始 pH 值的硼酸盐缓冲液组成的测试组合物特别适用于高范围葡萄糖的半定量测定（即葡萄糖浓度为 1,000 mg/dL 至 10,000 mg/dL）。首选的指示剂系统是水溶性碘盐和聚（乙烯基吡咯烷酮）。使用硼酸盐缓冲液可使初始 pH 值高于约 pH 值 7，当测试组合物加入载体基质以制备固态单元测试装置时，可大大提高高范围葡萄糖半定量测定的分辨率。