copper(II) cysteinate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: copper(II) cysteinate
• 英文别名: copper(II)-cysteine
• 化学式: 2C₃H₆NO₂S*Cu
• 分子量: 303.85
• InChiKey: NCKAHOTTZVIFBW-DKWTVANSSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.01
• 重原子数：
  8.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  66.15
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  copper(II) cysteinate 、 氨基硫脲 以 水 为溶剂， 生成 Cu(thiosemicarbazide)2(SCN)2
  参考文献：
  名称：

  Reaction of copper(II) cysteinate with thiosemicarbazide: Crystal structure of a complex of copper(II) thiocyanate with thiosemicarbazide

  摘要：

  The reaction of copper(II) cysteinate with thiosemicarbazide (TSC) in water was found to yield complex of copper(II) thiocyanate of the [Cu(TSC)(2)(SCN)(2)] composition, whose crystal structure was determined by X-ray crystallography. Crystals of the complex are triclinic with a = 6.040 , b = 7.112 , c = 8.276 angstrom , alpha = 91.34 degrees, beta = 101.72A degrees, gamma = 114.83A degrees, Z = 2, space group P. Structural units of the complex are [Cu(TSC)(2)](2+) centrosymmetric cations and (SCN)- anions linked by hydrogen bonds (HB), as well as by electrostatic and pi-pi stacking interactions. The coordination polyhedron of Cu atoms is a square completed to bipyramid; the bonds Cu(1)- N(3), Cu(1)- S(1), and Cu(1)- S(2) are 2.002 angstrom, 2.303 angstrom, and 3.015 angstrom, respectively.

  DOI：

  10.1134/s0036023612020027
• 作为产物：
  描述：

  DL-半胱氨酸 、 N-glycyl-glycine ; copper (II)-compound 以 水 为溶剂， 生成 copper(II)-glycylclycine-cysteine 、 copper(II) cysteinate
  参考文献：
  名称：

  INTERACTION OF BIOLOGICALLY RELEVANT Cu(II)-PEPTIDE AND CYSTEINE. TRANSIENT COMPLEXES WITH Cu(II)N₃S AND Cu(II)N₂S₂CHROMOPHORES

  摘要：

  Cu(II)-甘氨酰甘氨酸与半胱氨酸螯合，形成红紫色瞬态。混合反应物后立即形成的瞬态是三元 Cu(II) 络合物。另一个瞬态是由三元复合物连续产生的半胱氨酸二元 Cu(II) 复合物。讨论了这些瞬变的分光光度特性。

  DOI：

  10.1246/cl.1980.629

文献信息

• Albumin coated copper-cysteine nanozyme for reducing oxidative stress induced during sperm cryopreservation
  作者：Fariba Dashtestani、Hedayatollah Ghourchian、Atefeh Najafi

  DOI：10.1016/j.bioorg.2018.07.020

  日期：2018.10

  pyrogallol autoxidation method. The results revealed that NACu-Cys exhibited SOD mimetic activity with a half inhibition concentration (IC50) value of 7.0 × 10−3 µM and a turnover number (kcat) of 5.4 × 107 s−1. In the next step, this nanozyme was applied as a protective agent against oxidative stress induced by sperm cryopreservation. Increasing the motility, raising the viability and reducing the apoptosis

  在本工作中，合成了由Cu-Cys络合物和纳米白蛋白（NA）组成的SOD模拟纳米酶（NACu-Cys）。表征纳米酶后，通过抑制邻苯三酚自氧化方法评估其超氧化物歧化酶（SOD）行为。结果表明，NACu-半胱氨酸显示出SOD模拟活性有半数抑制浓度（IC 50）7.0×10的值- 3  μM和转换数（K猫的5.4×10）7 小号- 1。在下一步中，将该纳米酶用作抗精子冷冻保存诱导的氧化应激的保护剂。由于向人精子冷冻培养基中添加了NaCu-Cys，增加了运动能力，提高了生存能力，并减少了细胞凋亡。比较NACu-Cys的天然SOD和SOD模拟行为表明，该纳米颗粒具有在低温保存过程中用作氧化应激下降的能力。
• Determination of cysteine and glutathione based on the inhibition of the dinuclear Cu(II)-catalyzed luminol–H2O2 chemiluminescence reaction
  作者：Mohammad Javad Chaichi、Mahjoobeh Ehsani、Tahereh Khajvand、Hamid Golchoubian、Ehsan Rezaee

  DOI：10.1016/j.saa.2013.10.105

  日期：2014.3

  The catalyzed luminol chemiluminescent reaction has received a great amount of attention because of its high sensitivity and low background signal which make the reaction an attractive analytical chemistry tool. The present study, introduces the beneficial catalytic effects of dinuclear Cu(II) complex [Cu2L2(TAE)]X-2, where TAE = tetraacetylethane; L = N,N'-dibenzylethylenediamine and X = ClO4 on the luminol chemiluminescent reaction as a novel probe for the determination of glutathione (GSH) and L-cysteine (CySH) in human serum and urine. The [Cu2L2(TAE)]X-2 has exhibited highly efficient catalytic activity of luminol CL as an artificial peroxidase model at pH as low as 7.5 in water in the presence of H2O2 center dot GSH and CySH can induce a sharp decrease in CL intensity from the [Cu2L2(TAE)]X-2-catalyzed luminol system. Under the selected experimental conditions, a linear relationship was obtained between the CL intensity and the concentrations of GSH and CySH in the range of 1.0 x 10(-7)-1.0 x 10(-4) M, with detection limits (S/N = 3) of 2.7 x 10(-8) and 6.8 x 10(-8) M and RSD < 4.2% (n = 7) for GSH and CySH, respectively. (C) 2013 Elsevier B.V. All rights reserved.
• Reaction of copper(II) cysteinate with thiosemicarbazide: Crystal structure of a complex of copper(II) thiocyanate with thiosemicarbazide
  作者：A. S. Antsyshkina、G. G. Sadikov、T. V. Koksharova、V. S. Sergienko、D. A. Golub

  DOI：10.1134/s0036023612020027

  日期：2012.2

  The reaction of copper(II) cysteinate with thiosemicarbazide (TSC) in water was found to yield complex of copper(II) thiocyanate of the [Cu(TSC)(2)(SCN)(2)] composition, whose crystal structure was determined by X-ray crystallography. Crystals of the complex are triclinic with a = 6.040 , b = 7.112 , c = 8.276 angstrom , alpha = 91.34 degrees, beta = 101.72A degrees, gamma = 114.83A degrees, Z = 2, space group P. Structural units of the complex are [Cu(TSC)(2)](2+) centrosymmetric cations and (SCN)- anions linked by hydrogen bonds (HB), as well as by electrostatic and pi-pi stacking interactions. The coordination polyhedron of Cu atoms is a square completed to bipyramid; the bonds Cu(1)- N(3), Cu(1)- S(1), and Cu(1)- S(2) are 2.002 angstrom, 2.303 angstrom, and 3.015 angstrom, respectively.
• INTERACTION OF BIOLOGICALLY RELEVANT Cu(II)-PEPTIDE AND CYSTEINE. TRANSIENT COMPLEXES WITH Cu(II)N₃S AND Cu(II)N₂S₂CHROMOPHORES
  作者：Akira Hanaki

  DOI：10.1246/cl.1980.629

  日期：1980.6.5

  Cu(II)-glycylglycine chelates with cysteine forming red-purple transient. A transient which is formed immediately upon mixing the reactants is a ternary Cu(II) complex. Another transient is a binary Cu(II) complex of cysteine produced successively from the ternary complex. Spectrophotometric properties of those transients are discussed.

  Cu(II)-甘氨酰甘氨酸与半胱氨酸螯合，形成红紫色瞬态。混合反应物后立即形成的瞬态是三元 Cu(II) 络合物。另一个瞬态是由三元复合物连续产生的半胱氨酸二元 Cu(II) 复合物。讨论了这些瞬变的分光光度特性。