di-creatine malate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: di-creatine malate
• 英文别名: Creatine malate；2-[carbamimidoyl(methyl)amino]acetic acid;2-hydroxybutanedioic acid
• 化学式: C₄H₆O₅*2C₄H₉N₃O₂
• 分子量: 396.357
• InChiKey: IJHJWHALYRGNKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  185
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  苹果酸 、 肌酸 以 乙醇 为溶剂， 反应 0.5h， 生成 di-creatine malate
  参考文献：
  名称：

  Production process of dicreatine malate

  摘要：

  生产高纯度二甘氨酸马拉酸盐的过程包括以下步骤：提供预定量的苹果酸，将预定量的无水酒精与苹果酸搅拌以获得第一溶液，过滤第一溶液以形成清澈的溶液，将预定量的肌酸与清澈的溶液搅拌以获得第二溶液，离心第二溶液以获得湿二甘氨酸马拉酸盐和分离的酒精，将湿二甘氨酸马拉酸盐干燥以生产二甘氨酸。由于其低能耗，该过程有效地生产二甘氨酸马拉酸盐。

  公开号：

  US20050250962A1

文献信息

• [EN] TASTE-MODIFIED CREATINE SALTS, COMPOUNDS, COMPOSITIONS AND USES THEREOF<br/>[FR] SELS DE CRÉATINE AU GOÛT MODIFIÉ , COMPOSÉS, COMPOSITIONS ET LEURS UTILISATIONS
  申请人：UNIV RES INST INC AUGUSTA

  公开号：WO2018208647A1

  公开（公告）日：2018-11-15

  Provided are embodiments of creatine and creatine ethyl ester (CEE) salts where the anion is an artificial (non-saccharide) taste-modifier. These compounds represent stable white non-hygroscopic solids or semisolids that can readily dissolve in water and buffer solutions. Synthesis of novel creatine salts using environmentally safe solvents such as ethanol resulted in the formation of products in quantitative yields with sodium or potassium chloride as a byproduct. The creatine and creatine alkyl eater derivative salts are stable sweet-tasting compounds that are more palatable to a consumer than creatine or derivatives thereof.

  提供了肌酸和肌酸乙酯（CEE）盐的实施方式，其中阴离子是人工（非糖类）口味改良剂。这些化合物代表了稳定的白色非吸湿性固体或半固体，可以很容易地溶解在水和缓冲溶液中。使用环保溶剂（如乙醇）合成新型肌酸盐，可以得到产量定量的产物，其副产物为氯化钠或氯化钾。肌酸和肌酸烷基酯衍生物盐是稳定的甜味化合物，比肌酸或其衍生物更适合消费者口味。
• Ion-pair delivery system for cosmetic and pharmaceutical compositions
  申请人：——

  公开号：US20040228884A1

  公开（公告）日：2004-11-18

  This invention relates to a novel ion-pair delivery system useful for cosmetic, pharmaceutical, and topical nutraceutical applications in which the functional performance and consumer aesthetics of an electron donor composition and an electron acceptor composition, or a proton donor composition and a proton acceptor composition, are synergistically enhanced when such compositions are combined in an ion-pair mode. During ion-pair bonding process, the electron donor composition or the proton acceptor composition become positively charged and the electron acceptor composition or proton donor composition become negatively charged and thus bind together in an ionic manner. Such ion-pair compositions release their electronically bound components in their original state when such compositions are absorbed into skin and reach physiological pH conditions.

  本发明涉及一种新型离子对传递系统，可用于化妆品、药品和局部营养品应用中，其中当电子给体组成物和电子受体组成物，或质子给体组成物和质子受体组成物以离子对模式结合时，其功能性能和消费者美学效果得到协同增强。在离子对键合过程中，电子给体组成物或质子受体组成物变为带正电荷，而电子受体组成物或质子给体组成物则变为带负电荷，从而以离子方式结合在一起。这样的离子对组成物在吸收到皮肤并达到生理pH条件时，释放其电子结合的成分。
• Creatine hydroxycitric acids salts and methods for their production and use in individuals
  申请人：Gardiner T. Paul

  公开号：US20060194877A1

  公开（公告）日：2006-08-31

  Methods of production for Tricreatine Hydroxycitrate are disclosed. Tricreatine hydroxycitrate can be used as supplemental dietary ingredient for the purposes of reducing adiposity, suppression of appetite, improvement of muscle and exercise performance and recovery. The salts are useful in the dietetic, food supplement and food industries.

  公开了三甘氨酸羟基柠檬酸盐的生产方法。三甘氨酸羟基柠檬酸盐可用作补充饮食成分，以减少脂肪，抑制食欲，提高肌肉和运动表现以及恢复。这些盐在饮食、食品补充剂和食品工业中非常有用。
• Creatine Hydroxycitric Acids Salts and Methods for their Production and use in Individuals
  申请人：Gardiner Paul T.

  公开号：US20080300309A1

  公开（公告）日：2008-12-04

  Methods of production for Tricreatine Hydroxycitrate are disclosed. Tricreatine hydroxycitrate can be used as supplemental dietary ingredient for the purposes of reducing adiposity, suppression of appetite, improvement of muscle and exercise performance and recovery. The salts are useful in the dietetic, food supplement and food industries.

  揭示了Tricreatine Hydroxycitrate的生产方法。Tricreatine hydroxycitrate可用作补充饮食成分，用于减少脂肪，抑制食欲，改善肌肉和运动表现以及恢复。这些盐在饮食、食品补充剂和食品工业中非常有用。
• Sustained release supplements
  申请人：Golini, Jeffrey M.

  公开号：EP1859794A1

  公开（公告）日：2007-11-28

  The invention relates to oral sustained release composition comprising creatine or a creatine salt or ester. The invention includes compositions with one or more excipients, where at least one excipient is capable of delaying release of the creatine. The invention also includes oral dosage forms having an enteric coating.

  本发明涉及包含肌酸或肌酸盐或酯的口服缓释组合物。本发明包括含有一种或多种赋形剂的组合物，其中至少一种赋形剂能够延迟肌酸的释放。本发明还包括具有肠溶衣的口服剂型。