N-[2-(acetylamino)ethyl]methacrylamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[2-(acetylamino)ethyl]methacrylamide
• 英文别名: N-(2-acetamidoethyl)-2-methylprop-2-enamide
• 化学式: C₈H₁₄N₂O₂
• 分子量: 170.211
• InChiKey: PNOPBLIRQCBZBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-乙酰-L-半胱氨酸 、 N-[2-(acetylamino)ethyl]methacrylamide 在 ammonium hydroxide 、 sodium cyanoborohydride 作用下， 以 水 为溶剂， 反应 72.0h， 以45%的产率得到
  参考文献：
  名称：

  硫醇基迈克尔型加成。系统评估其控制因素

  摘要：

  本文是关于控制这种流行的生物共轭反应动力学和产物稳定性的因素。我们证明a）硫醇pKa，即硫醇盐的量，是亲核试剂反应动力学的唯一决定因素；b）产物降解主要通过水解（而非硫醇交换）发生，并且对于反应最迅速的亲电试剂更为突出。在分子设计方面，丙烯酰胺和低pKa硫醇作为反应伙伴出现，为稳定性和反应速率提供了最佳折衷方案。

  DOI：

  10.1016/j.tet.2020.131637
• 作为产物：
  描述：

  N-乙酰基乙二胺 、 甲基丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以86%的产率得到N-[2-(acetylamino)ethyl]methacrylamide
  参考文献：
  名称：

  硫醇基迈克尔型加成。系统评估其控制因素

  摘要：

  本文是关于控制这种流行的生物共轭反应动力学和产物稳定性的因素。我们证明a）硫醇pKa，即硫醇盐的量，是亲核试剂反应动力学的唯一决定因素；b）产物降解主要通过水解（而非硫醇交换）发生，并且对于反应最迅速的亲电试剂更为突出。在分子设计方面，丙烯酰胺和低pKa硫醇作为反应伙伴出现，为稳定性和反应速率提供了最佳折衷方案。

  DOI：

  10.1016/j.tet.2020.131637

文献信息

• OPTICAL DETERMINATION OF GLUCOSE UTILIZING BORONIC ACID ADDUCTS
  申请人：The Regents of the University of California

  公开号：US20130121925A1

  公开（公告）日：2013-05-16

  The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

  本发明涉及一种改进的光学方法和光学传感器装置，用于在体内和/或体外的水介质中确定多羟基取代有机分子的水平。检测范围在大约400到800纳米之间。特别地，实现了一种感应装置在哺乳动物中用于确定糖的水平。具体而言，将染料与共轭含氮杂环芳基硼酸取代的双阳离子化合物结合在糖的存在下，例如果糖或葡萄糖。香兰素是首选的芳香族共轭含氮芳基硼酸取代化合物。该方法有助于确定人体中的糖水平。
• POLYMERIZABLE LIQUID CRYSTAL COMPOUND, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTALLINE POLYMER, AND OPTICAL ANISOTROPIC ARTICLE
  申请人：Sakamoto Kei

  公开号：US20100258764A1

  公开（公告）日：2010-10-14

  A polymerizable liquid crystal compound shown by the following formula (I), a polymerizable liquid crystal composition that includes the polymerizable liquid crystal compound and a chiral compound polymerizable with the polymerizable liquid crystal compound, a liquid crystalline polymer obtained by polymerizing the polymerizable liquid crystal compound or the polymerizable liquid crystal composition, and an optical anisotropic article that includes the liquid crystalline polymer. The polymerizable liquid crystal compound shows a liquid crystal phase over a wider temperature range, is chemically stable, can be inexpensively produced, and has a wide selective reflection wavelength band Δλ (i.e., a large value Δn). The polymerizable liquid crystal composition includes the polymerizable liquid crystal compound, the liquid crystalline polymer is obtained by polymerizing the polymerizable liquid crystal compound or the polymerizable liquid crystal composition, and the optical anisotropic article includes the liquid crystalline polymer. wherein Y 1 to Y 6 represent —O—, —O—C(═O)—, —C(═O)—O—, or the like, G 1 and G 2 represent divalent aliphatic groups having 1 to 20 carbon atoms, Z 1 and Z 2 represent an alkenyl group having 2 to 10 carbon atoms or the like, A 1 and A 2 represent divalent organic groups A having 1 to 30 carbon atoms, X 1 to X 8 represent a hydrogen atom or the like, and a and b represent 0 or 1.
• POLYMERIZABLE LIQUID CRYSTAL COMPOUND, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, POLYMER AND FILM
  申请人：KATOH Shunya

  公开号：US20110233464A1

  公开（公告）日：2011-09-29

  A polymerizable liquid crystal compound represented by formula (I) is disclosed. R 0 and R 1 represent a hydrogen atom, or C 1-4 alkyl; L 0 and L 1 represent a hydrogen atom, or C 1-4 alkyl group; A 0 and A 1 represent a divalent linking group having a 5- to 12-membered cyclic structure; B 0 and B 1 represent a single bond or a divalent linking group having a 5- to 12-membered cyclic structure; D 0 and D 1 represent —O—, —S—, or —NR 2 —; X 0 and X 1 represent a hydrogen atom, acyl group or cyano; Y 0 and Y 1 represent a single bond or a divalent group; Q 0 and Q 1 represent a C 1-20 divalent aliphatic group; Z 0 and Z 1 represent a hydrogen atom, cyano, halogen atom or polymerizable group; and n and m each independently represent an integer of from 0 to 2.
• US7470420B2
  申请人：——

  公开号：US7470420B2

  公开（公告）日：2008-12-30
• US7968714B2
  申请人：——

  公开号：US7968714B2

  公开（公告）日：2011-06-28