zinc di(lysinate) | 23333-98-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: zinc di(lysinate)
• 英文别名: Zn(lysine)₂；zinc L-lysinate；zinc;(2S)-2,6-diaminohexanoate
• CAS: 23333-98-4
• 化学式: C₁₂H₂₆N₄O₄Zn
• 分子量: 355.753
• InChiKey: NJNDBGREJCHIFG-MDTVQASCSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.62
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  184
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  全顺式二十碳五烯酸 、 zinc di(lysinate) 在 水 作用下， 以 甲醇 为溶剂， 反应 0.33h， 以92%的产率得到zinc bis-lysinate bis-EPA monohydrate
  参考文献：
  名称：

  Mineral Amino-Acid Complexes of Fatty Acids

  摘要：

  本发明涉及具有氨基酸组分、二价金属组分和对离子组分的化合物III的组合物，包含相同成分的组合物，以及使用方法。

  公开号：

  US20150366980A1
• 作为产物：
  描述：

  L-赖氨酸 、 zinc(II) hydroxide 以 乙醇 为溶剂， 反应 4.0h， 以92%的产率得到zinc di(lysinate)
  参考文献：
  名称：

  Mineral Amino-Acid Complexes of Fatty Acids

  摘要：

  本发明涉及具有氨基酸组分、二价金属组分和对离子组分的化合物III的组合物，包含相同成分的组合物，以及使用方法。

  公开号：

  US20150366980A1

文献信息

• [EN] AN ANTIPERSPIRANT COMPOSITION<br/>[FR] COMPOSITION ANTITRANSPIRANTE
  申请人：UNILEVER NV

  公开号：WO2020030414A1

  公开（公告）日：2020-02-13

  The present invention is in the field of personal care compositions, in particular compositions comprising antiperspirant actives. The present invention more particularly relates to compositions which do not contain the conventional and well established aluminium based actives, yet exhibit similar efficacy. This is achieved through use of an active which is a complex of a zinc salt with a β amino acid in an anhydrous carrier.

  本发明涉及个人护理组合物领域，特别是包含止汗活性成分的组合物。本发明更特别涉及不含传统和已建立的铝基活性成分的组合物，但具有类似功效的组合物。这是通过在无水载体中使用锌盐与β氨基酸的复合物来实现的。
• ENHANCED BIOAVAILABLE IODINE MOLECULES
  申请人：ZINPRO CORPORATION

  公开号：US20130225847A1

  公开（公告）日：2013-08-29

  This invention relates to supplementation of the diets of domesticated animals (livestock and poultry) with iodine in an enhanced bioavailable manner, that is to say the iodine is more available to the animal than when using conventional sources of iodine, such as calcium iodate. The supplementary compound are alpha amino acid metal iodide complexes.

  这项发明涉及以增强的生物利用方式为家畜（牲畜和家禽）的饲料补充碘，即碘对动物更易利用，而不是使用传统的碘来源（如碘酸钙）。补充物是α氨基酸金属碘化物复合物。
• ENERGY-EFFICIENT SOLVENT-FREE METHOD FOR PRODUCING METAL CHELATES
  申请人：TECHNISCHE UNIVERSITAT CLAUSTHAL

  公开号：US20210309674A1

  公开（公告）日：2021-10-07

  The invention relates to a method for producing, amongst other things, amino-acid and/or hydroxycarboxylic-acid metal chelates, a solvent-free mixture of at least one metal oxide, metal hydroxide, metal carbonate or oxalate, and the solid organic acid is subjected to intensive mechanical stress. According to the invention, this is done in that the reaction partners are introduced in particle form into a fluid stream of a fluid-bed countercurrent mill operating without grinding elements, wherein mechanical activation of at least one of the reaction partners is effected by collision processes within a reaction chamber formed in a region of the fluid stream, and a solid body reaction to form the metal chelate is triggered. The novel method operates very energy-efficiently and with a high specific yield. It leads to a product having compact particles in the small, single-digit micrometer range having a comparatively narrow particle size distribution and a large surface. The product is homogenous and very pure. Thermal loading or decomposition of the organic chelate ligands, in particular of the amino acids, is likewise avoided, as are contaminants from milling and grinding element abrasion.

  该发明涉及一种制备氨基酸和/或羟基羧酸金属螯合物的方法，其中包括无溶剂的至少一种金属氧化物、金属氢氧化物、金属碳酸盐或草酸盐的混合物，以及将固体有机酸受到强烈机械应力。根据该发明，通过将反应物以颗粒形式引入无磨粒元素运行的流化床逆流磨中，其中至少一个反应物的机械活化通过在流体流动区域内形成的反应室内的碰撞过程来实现，并触发形成金属螯合物的固体体反应。这种新方法运行非常节能，并具有高特定产量。它导致产物具有在小型、个位数微米范围内的致密颗粒，具有相对较窄的颗粒大小分布和大表面。该产品是均匀且非常纯净的。同时也避免了有机螯合配体（特别是氨基酸）的热负荷或分解，以及来自磨削和磨粒元素磨损的污染物。
• Methods for Synthesizing Zinc-Lysine-Chloride Complex
  申请人：Colgate-Palmolive Company

  公开号：US20200199156A1

  公开（公告）日：2020-06-25

  Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc halide and amino acid free base in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.

  本文披露了一种改进的方法，通过在聚醇溶剂中反应锌卤化物和氨基酸游离基合成锌氨基酸卤化物复合物，以及根据该方法制备的含有该复合物的口腔护理组合物。
• Multifunction "Crown Complexes" from Amino Acids and Peptides for Skin and Hair Restoration
  申请人：Gupta K Shyam

  公开号：US20070099886A1

  公开（公告）日：2007-05-03

  This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.

  本发明涉及从氨基酸和羟基芳基烷基酮衍生的席夫碱，或含有该类化合物的植物提取物，其具有图1中的一般化学结构，用于局部应用。本发明还涉及所述席夫碱的某些金属配合物，其在三维化学结构中呈冠状外观，如图2所示。本发明的席夫碱及其金属配合物对于调节金属活化酶和金属酶，例如苯丙氨酸羟化酶、酪氨酸转氨酶、苯丙氨酸转氨酶、酪氨酸酶、各种基质金属蛋白酶、超氧化物歧化酶、5α-还原酶和柠檬酸裂解酶具有用途。此外，它们还适用于多功能局部方法，如美白肌肤、减少皮肤皱纹、抗衰老、胶原蛋白合成、控制痤疮、预防脱发、控制白发和面部油脂控制。