2-bromo-4,5-dimethoxypropylbenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromo-4,5-dimethoxypropylbenzene
• 英文别名: 1-Bromo-4,5-dimethoxy-2-propylbenzene
• 化学式: C₁₁H₁₅BrO₂
• 分子量: 259.143
• InChiKey: SIKSLVYSYJNCBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bromo-4,5-dimethoxypropylbenzene 在 溶剂黄146 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 以74%的产率得到(E)-2-bromo-4,5-dimethoxycinnamaldehyde
  参考文献：
  名称：

  Efficient one-pot, two-step synthesis of (E)-cinnmaldehydes by dehydrogenation–oxidation of arylpropanes using DDQ under ultrasonic irradiation

  摘要：

  A general, efficient and new approach to the synthesis of cinnamaldehydes with trans-selectivity has been accomplished starting from arylpropanes. One-pot, two-step dehydrogenation and oxidation of arylpropanes with excess DDQ in dioxane containing a few drops of acetic acid gave (E)-cinnmaldehydes under ultrasound irradiation. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.12.028

文献信息

• ONE POT MULTICOMPONENT SYNTHESIS OF SOME NOVEL HYDROXY STILBENE DERIVATIVES WITH ALPHA, BETA-CARBONYL CONJUGATION UNDER MICROWAVE IRRADIATION
  申请人：Sharma Abhishek

  公开号：US20120165567A1

  公开（公告）日：2012-06-28

  The present invention provides a method for the preparation of some novel multiconjugated 2- or 4-hydroxy substituted stilbenes. The method provides one pot multicomponent approach wherein 3-4 step reaction sequences viz. condensation, decarboxylation and Heck coupling occur simultaneously which results in an enhanced yield of desired products and reduced reaction times

  本发明提供了一种制备一些新型多共轭2-或4-羟基取代的stilbenes的方法。该方法提供了一锅多组分方法，其中包括3-4步反应序列，即缩合、脱羧和Heck偶联同时发生，从而提高了所需产品的产量，减少了反应时间。
• US8716532B2
  申请人：——

  公开号：US8716532B2

  公开（公告）日：2014-05-06
• [EN] ONE POT MULTICOMPONENT SYNTHESIS OF SOME NOVEL HYDROXY STILBENE DERIVATIVES WITH ALPHA, BETA-CARBONYL CONJUGATION UNDER MICROWAVE IRRADIATION<br/>[FR] SYNTHÈSE MULTICOMPOSANTS EN UN SEUL RÉCIPIENT DE CERTAINS NOUVEAUX DÉRIVÉS HYDROXYSTILBÈNE AVEC CONJUGAISON ALPHA, BÊTA-CARBONYLE SOUS RAYONNEMENT MICROONDE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2010113005A2

  公开（公告）日：2010-10-07

  The present invention provides a method for the preparation of some novel commercially important multiconjugated 2- or 4-hydroxy substituted stilbenes including lithospermic acid based stilbene analogues possessing an α, β-unsaturated carboxylic acid moiety i.e. (C6-C2-C6-C3 chain) with wide ranging applications as potent pharmcophores for diverse ailments including diabetes and cardiovascular disorders, besides finding usage in non-linear optical devices and optoelectronics etc. The method provides a unique one pot multicomponent approach wherein 3-4 step reaction sequences viz. condensation, decarboxylation and Heck coupling occur simultaneously either the need for decarboxylating/protection-deprotection agents or individual isolation of highly reactive intermediates which results in an enhanced yield of desired products and reduced reaction times. The present invention dispenses with the hitherto indispensable requirement for multistep approaches for a diverse range of hydroxy stilbene derivatives through a one pot muticomponent synthetic strategy.
• Efficient one-pot, two-step synthesis of (E)-cinnmaldehydes by dehydrogenation–oxidation of arylpropanes using DDQ under ultrasonic irradiation
  作者：Bhupendra P. Joshi、Anuj Sharma、Arun K. Sinha

  DOI：10.1016/j.tet.2005.12.028

  日期：2006.3

  A general, efficient and new approach to the synthesis of cinnamaldehydes with trans-selectivity has been accomplished starting from arylpropanes. One-pot, two-step dehydrogenation and oxidation of arylpropanes with excess DDQ in dioxane containing a few drops of acetic acid gave (E)-cinnmaldehydes under ultrasound irradiation. (c) 2005 Elsevier Ltd. All rights reserved.