2-methoxy-4-(1,3-oxathiolan-2-yl)phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-methoxy-4-(1,3-oxathiolan-2-yl)phenol
• 化学式: C₁₀H₁₂O₃S
• 分子量: 212.269
• InChiKey: RSLPSONLCVSXRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  64
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  香草醛 、 2-巯基乙醇 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 以63%的产率得到2-methoxy-4-(1,3-oxathiolan-2-yl)phenol
  参考文献：
  名称：

  N-溴代琥珀酰亚胺对羰基化合物的氧硫代乙缩醛化，硫代缩醛化和反硫代缩醛化：选择性和范围

  摘要：

  使用N-溴代琥珀酰亚胺作为催化剂，已经以高收率实现了羰基化合物的有效的氧代硫代缩醛化，硫代缩醛化和反硫代缩醛化。

  DOI：

  10.1016/s0040-4039(02)01610-6

文献信息

• [EN] NOVEL METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASES<br/>[FR] NOUVELLES MÉTHODES DE TRAITEMENT DES MALADIES INFLAMMATOIRES
  申请人：CORTICAL PTY LTD

  公开号：WO2004089927A1

  公开（公告）日：2004-10-21

  Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as a part of combination therapy. Novel compounds of formula (I) are also provided for.

  提供了抑制巨噬细胞迁移抑制因子（MIF）细胞因子或生物活性的方法，包括将MIF与式（I）化合物接触。该发明还涉及治疗MIF细胞因子或生物活性参与的疾病或病况的方法，包括给予式（I）化合物的治疗，可以单独使用或作为联合疗法的一部分。还提供了式（I）的新化合物。
• Oxathioacetalization, thioacetalization and transthioacetalization of carbonyl compounds by N-bromosuccinimide: selectivity and scope
  作者：Ahmed Kamal、Gagan Chouhan、Kaleem Ahmed

  DOI：10.1016/s0040-4039(02)01610-6

  日期：2002.9

  Efficient oxathioacetalization, thioacetalization and transthioacetalization of carbonyl compounds have been achieved in high yields employing N-bromosuccinimide as a catalyst.

  使用N-溴代琥珀酰亚胺作为催化剂，已经以高收率实现了羰基化合物的有效的氧代硫代缩醛化，硫代缩醛化和反硫代缩醛化。
• Novel methods for the treatment of inflammatory diseases
  申请人：Morand Francis Eric

  公开号：US20070010563A1

  公开（公告）日：2007-01-11

  Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as a part of combination therapy. Novel compounds of formula (I) are also provided for.

  本发明提供了抑制巨噬细胞迁移抑制因子（MIF）细胞因子或生物活性的方法，包括将MIF与式（I）化合物接触。本发明还涉及治疗MIF细胞因子或生物活性涉及的疾病或病症的方法，包括单独或作为联合治疗的一部分给予式（I）化合物。本发明还提供了新的式（I）化合物。
• Novel Methods for the Treatment of Inflammatory Diseases
  申请人：Morand Eric Francis

  公开号：US20100324001A1

  公开（公告）日：2010-12-23

  Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as a part of combination therapy. Novel compounds of formula (I) are also provided for.

  本发明提供了抑制巨噬细胞迁移抑制因子（MIF）的细胞因子或生物活性的方法，包括使用式（I）的化合物接触MIF。本发明还涉及治疗MIF细胞因子或生物活性参与的疾病或病症的方法，包括单独或作为联合治疗的一部分给予式（I）的化合物。本发明还提供了新的式（I）化合物。
• Tantalum(V) Chloride–Silica Gel: An Efficient Catalyst for Conversion of Carbonyl Compounds to 1,3‐Oxathiolanes
  作者：S. Chandrasekhar、S. Jaya Prakash、T. Shyamsunder、T. Ramachandar

  DOI：10.1080/00397910500282588

  日期：2005.12.1

  A variety of carbonyl compounds can be easily converted to the corresponding 1,3-oxathiolanes in the presence of a catalytic amount of tantalum(V) chloride [TaCl5] on silica gel in dichloromethane. Mild reaction conditions, efficiency, high yields, operational simplicity, and only 2.5 mol% of TaCl5 catalyst are some of the major advantages of the procedure.