N-tetradecanoyl-L-homoserine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-tetradecanoyl-L-homoserine
• 英文别名: (2S)-4-hydroxy-2-(tetradecanoylamino)butanoic acid
• 化学式: C₁₈H₃₅NO₄
• 分子量: 329.48
• InChiKey: NXPWNQYFYMELCY-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  L-高丝氨酸 、 肉豆蔻酰氯 在 potassium hydrogencarbonate 作用下， 以 乙醚 、 水 为溶剂， 反应 20.0h， 以85%的产率得到N-tetradecanoyl-L-homoserine
  参考文献：
  名称：

  Lipid A and Related Compounds. XXXII. Synthesis of Biologically Active N-Acylated L-Homoserine-Containing D-Glucosamine-4-phosphate Derivatives Structurally Related to Lipid A.

  摘要：

  合成了新的N-酰化L-同脯氨酸非磷酸化和磷酸化的D-葡萄糖胺衍生物，作为脂质A二糖的模拟物。其中一些合成的化合物表现出促增殖活性和一氧化氮（NO）产生能力。

  DOI：

  10.1248/cpb.45.312

文献信息

• METHODS FOR INDUCING AUTOLYSIS IN INFECTIOUS BACTERIA
  申请人：Haptogen Ltd

  公开号：EP1730197B1

  公开（公告）日：2012-03-07
• Novel autoinducer molecules and uses therefor
  申请人：Pesci C. Everett

  公开号：US20050009869A1

  公开（公告）日：2005-01-13

  Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal (“PQS”) molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signalling in bacteria using the compounds of the invention are also described.
• Quorum sensing signaling in bacteria
  申请人：Whiteley Marvin

  公开号：US20050227345A1

  公开（公告）日：2005-10-13

  The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginosa. Novel indicator strains and vectors for engineering the strains for use in the method of the invention are also provided.
• SYSTEMS AND METHODS FOR DIAGNOSIS AND MONITORING OF BACTERIA-RELATED CONDITIONS
  申请人：Daunert Sylvia

  公开号：US20100291566A1

  公开（公告）日：2010-11-18

  The presently-disclosed subject matter provides systems, methods, and kits for diagnosing and/or monitoring a bacteria-related condition of interest in a subject by providing a cell sensing system, each system containing a reporter molecule capable of detecting binding of a quorum sensing molecule and capable of generating a detectable signal.
• HIGH-THROUGHPUT IN VITRO TRANSLATION (CELL-LYSATE BASED) ASSAY FOR DETECTING QUORUM SENSING SIGNALS
  申请人：Decho Alan W.

  公开号：US20120164672A1

  公开（公告）日：2012-06-28

  A cell-lysate extract based assay reagent for detecting quorum sensing signals is generally provided, along with methods of making and using the same. The assay reagent generally includes a cell-lysate extract formed from a biosensor bacterium (e.g., Agrobacterium tumefaciens NTL4 (pCF218)(pCF372)) and a detecting substrate (e.g., an absorbance-based or luminescence-based substrate). The cell-lysate extract can be prepared by (1) disrupting the cell membranes of the biosensor bacterium to release the cellular components into a solution, (2) centrifuging the resulting solution, and (3) removing the resulting supernatant solution.