methacrylic acid-(EO)5-methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methacrylic acid-(EO)5-methyl ester
• 英文别名: m-PEG5-2-methylacrylate；2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate
• 化学式: C₁₅H₂₈O₇
• 分子量: 320.383
• InChiKey: LJFWOCHHKHGDMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  methacrylic acid-(EO)5-methyl ester 、 N-乙烯基己内酰胺 生成 poly(methacrylic acid-(EO)5-methyl ester-co-vinylcaprolactam)
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS
  申请人：The Hong Kong Polytechnic University

  公开号：US20150011513A1

  公开（公告）日：2015-01-08

  A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters. The EC50 values for reversing paclitaxel resistance (141-340 nM) of LCC6MDR cells, DOX (78-590 nM) and vincristine (82-550 nM) resistance of 2008/MRP1 cells and topotecan resistance (0.9-135 nM) of HEK293/R2 and MCF7-MX100 cells were at nanomolar range. Importantly, a number of compounds displayed EC50 at or below 10 nM in BCRP-overexpressed cell lines, indicating that these bivalent triazoles more selectively inhibit BCRP transporter than the P-gp and MRP1 transporters. Most of the dimers are notably safe MDR chemosensitizers as indicated by their high therapeutic index values.

  通过一系列含有三唑桥联类黄酮二聚物的合成，使用环加成反应，利用一系列含有黄酮基团的叠氮化物（Az1-15）和炔烃（Ac1-17）构建了一个高效的化合物库。这些三唑桥联的类黄酮二聚体及其前体炔基和叠氮基类黄酮被筛选，以评估它们对过表达P-gp的细胞系（LCC6MDR）、MRP1过表达的细胞系（2008/MRP1）和BCRP过表达的细胞系（HEK293/R2和MCF7-MX100）调节多药耐药性（MDR）的能力。总体而言，它们展现了极具前景的P-gp、MRP1和BCRP介导的药物耐药性的MDR逆转活性。此外，它们显示出对各种转运体的不同程度的选择性。总体而言，它们可以分为单选择性、双选择性和多选择性的P-gp、MRP1和BCRP转运体调节剂。对于LCC6MDR细胞的紫杉醇耐药性（141-340 nM）、2008/MRP1细胞的DOX（78-590 nM）和长春新碱（82-550 nM）耐药性以及HEK293/R2和MCF7-MX100细胞的拓扑替康耐药性（0.9-135 nM），它们的EC50值处于纳摩尔范围。重要的是，许多化合物在BCRP过表达的细胞系中显示出EC50值在或低于10 nM，表明这些双价三唑更有选择性地抑制BCRP转运体而不是P-gp和MRP1转运体。大多数二聚体的治疗指数值非常高，表明它们是非常安全的MDR化疗敏感剂。
• Fluorine-containing AB-type block copolymer
  申请人：MITSUBISHI PETROCHEMICAL CO., LTD.

  公开号：EP0291297A2

  公开（公告）日：1988-11-17

  A fluorine-containing AB-type block copolymer is disclosed having a fluorine-containing polymer chain and a polymer chain having affinity for a resin whereby properties possessed by fluorine atoms such as water repellency, oil repellency and staining resistance are imported to the surface or interface of the resin to be modified.

  本发明公开了一种含氟 AB 型嵌段共聚物，它具有一条含氟聚合物链和一条与树脂具有亲和力的聚合物链，从而将氟原子所具有的憎水性、憎油性和抗污性等特性导入到待改性树脂的表面或界面。
• Terpolymer flocculants
  申请人：S. N. F.

  公开号：EP0469196A1

  公开（公告）日：1992-02-05

  Water soluble terpolymers based on (1) an acrylamide or acrylamide derivative, (2) a cationic vinyl monomer and (3) a hydrophilic vinyl monomer of the formula CH2C(R)C(O)O(CH2(CH2)mO)nE where R and E are each hydrogen or alkyl, m is an integer from 1 to 3 and n is an integer from 1 to 25 are useful flocculants.

  水溶性三元共聚物基于 (1) 丙烯酸酰胺或丙烯酰胺衍生物，(2) 阳离子乙烯基单体和 (3) 式 CH2C(R)C(O)O(CH2(CH2)mO)nE 的亲水性乙烯基单体，其中 R 和 E 分别为氢或烷基，m 为 1 至 3 的整数，n 为 1 至 25 的整数，是有用的絮凝剂。
• Microcapsules
  申请人：Takasago International Corporation

  公开号：EP2832440A1

  公开（公告）日：2015-02-04

  The present disclosure discloses a novel microcapsule which is endowed for example with reduced leakage of encapsulated materials. The microcapsule contains one or more fragrances and is suitable for inclusion in non-edible consumer goods products, laundry products, personal care products and cosmetic products. The microcapsule can be obtained in an economic and efficient manner by polymerizing an emulsion so that emulsion droplets are encapsulated into a subsequently cured polymeric shell.

  本公开披露了一种新型微胶囊，它具有减少封装材料渗漏等特点。这种微胶囊含有一种或多种香料，适用于非食用消费品、洗衣产品、个人护理产品和化妆品。微胶囊可以通过聚合乳液，使乳液液滴被封装到随后固化的聚合物外壳中，从而以经济高效的方式获得。
• FINE METAL PARTICLE DISPERSANT, FINE METAL PARTICLE DISPERSED LIQUID, AND CURED FILM
  申请人：Harima Chemicals, Inc.

  公开号：EP2962750A1

  公开（公告）日：2016-01-06

  A metal fine particle dispersant is obtained by reaction of a polymer (a) containing a first reactive functional group, an ionic group to be absorbed to metal fine particles, and a polyoxyalkylene side chain with a compound (b) containing a second reactive functional group to be bonded to the first reactive functional group and an active energy ray curable group to be cured by an active energy ray. A metal fine particle dispersion liquid containing the metal fine particle dispersant, metal fine particles, and a dispersion medium is prepared. The metal fine particle dispersion liquid is cured, thereby obtaining a cured film.

  将含有第一活性官能团、可被金属微粒吸收的离子基团和聚氧亚烷基侧链的聚合物 (a) 与含有可与第一活性官能团结合的第二活性官能团和可被活性能量射线固化的活性能量射线可固化基团的化合物 (b) 反应，可获得金属微粒分散剂。制备含有金属微粒分散剂、金属微粒和分散介质的金属微粒分散液。固化金属微粒分散液，从而获得固化薄膜。