decanoyl valine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: decanoyl valine
• 英文别名: 2-Decanamido-3-methylbutanoic acid；2-(decanoylamino)-3-methylbutanoic acid
• 化学式: C₁₅H₂₉NO₃
• mdl: MFCD00437416
• 分子量: 271.4
• InChiKey: OUCCJWNTVXTJDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.866
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  alpha-D-半乳糖 、 decanoyl valine 在 lipozyme thermomyces lanuginosus immobilized on silica 作用下， 以 叔丁醇 为溶剂， 反应 6.0h， 以89.6%的产率得到1-O-(N-decanoylvalineyl)-D-galactosyl ester
  参考文献：
  名称：

  Enzymatic synthesis and characterization of galactosyl monoesters

  摘要：

  Enzyme-catalyzed synthesis of several fatty acyl-amino acid esters based on D-galactose, as well as their chemical evaluation, was performed. These novel galactosyl fatty acyl-amino acid monoesters were synthesized by utilizing lipase from lipozyme TL IM in tert-butanol with D-galactose and fatty acyl-amino acids as starting materials. The products were characterized by H-1 NMR, C-13 NMR and MS analysis. In addition, their primary physical properties, such as hydrophilic-lipophilic balance (HLB), critical micellar concentration (CMC), solubility in water, maximum surface excess (Gamma(max)), and minimal surface tension (A(min)) were measured. The experimental results showed that their CMC values are between 5 and 0.4 mM. The HLB values of galactosyl esters 15-17 indicate that they are useful as oil-in-water emulsions or detergents, whereas 18-22 can be employed as water-in-oil emulsifiers or wetting agents. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2015.05.011
• 作为产物：
  描述：

  sodium DL-2-aminoisovalerate 、 癸酰氯 以 水 为溶剂， 反应 1.0h， 生成 decanoyl valine
  参考文献：
  名称：

  Iyer, Venkataraman N.; Sheth, Geeta N.; Subrahmanyam, V. V. R., Journal of the Indian Chemical Society, 1982, vol. 59, # 7, p. 856 - 859

  摘要：

  DOI：

文献信息

• MOISTURIZER AND COSMETIC CONTAINING SAME
  申请人：Ajinomoto Co., Inc.

  公开号：EP3366273A1

  公开（公告）日：2018-08-29

  An object of the present invention is to provide a moisturizer that can sufficiently promote the production of moisturizing-related proteins and can achieve sufficient moisturizing effect. In other words, the present invention provides a moisturizer including an acyl neutral amino acid involving an acyl group having a carbon atom number of 2 to 18 or a salt thereof, and a cosmetic including the moisturizer. The moisturizer and the cosmetic of the present invention can promote the production of one or more moisturizing-related proteins selected from the group consisting of filaggrin, involucrin, transglutaminase 1, keratin 10, and loricrin.

  本发明的目的是提供一种保湿剂，它能充分促进保湿相关蛋白质的生成，并能达到充分的保湿效果。换句话说，本发明提供了一种保湿剂，其中包括一种酰基中性氨基酸，涉及的酰基的碳原子数为 2 至 18 或其盐，以及一种包括该保湿剂的化妆品。本发明的保湿剂和化妆品可以促进一种或多种保湿相关蛋白的产生，这些蛋白选自丝胶蛋白、总纤毛蛋白、转谷氨酰胺酶 1、角蛋白 10 和 loricrin 所组成的组。
• Moisturizer and cosmetic including the same
  申请人：AJINOMOTO CO., INC.

  公开号：US10406086B2

  公开（公告）日：2019-09-10

  Moisturizers including an acyl neutral amino acid having an acyl group with a carbon atom number of 2 to 18, and salts thereof, and cosmetics containing such a moisturizer promote the production of moisturizing-related proteins, such as filaggrin, involucrin, transglutaminase 1, keratin 10, and loricrin, and provide a moisturizing effect.

  包括具有碳原子数为 2 至 18 的酰基的酰基中性氨基酸及其盐类的保湿剂，以及含有此类保湿剂的化妆品，可促进保湿相关蛋白质（如丝胶蛋白、内含蛋白、转谷氨酰胺酶 1、角蛋白 10 和 loricrin）的生成，并提供保湿效果。
• Iyer, Venkataraman N.; Sheth, Geeta N.; Subrahmanyam, V. V. R., Journal of the Indian Chemical Society, 1982, vol. 59, # 7, p. 856 - 859
  作者：Iyer, Venkataraman N.、Sheth, Geeta N.、Subrahmanyam, V. V. R.

  DOI：——

  日期：——
• PHARMACEUTICAL FORMULATIONS FOR THE ORAL DELIVERY OF PEPTIDE OR PROTEIN DRUGS
  申请人：Cyprumed GmbH

  公开号：EP3204045B1

  公开（公告）日：2018-12-05
• FAST-ACTING PLANT-BASED MEDICINAL COMPOUNDS AND NUTRITIONAL SUPPLEMENTS
  申请人：Receptor Holdings, Inc.

  公开号：EP3548018A1

  公开（公告）日：2019-10-09