2-hydroxyethyl linolenate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-hydroxyethyl linolenate
• 英文别名: α-linolenic acid 2-hydroxyethyl ester；2-hydroxyethyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
• 化学式: C₂₀H₃₄O₃
• 分子量: 322.488
• InChiKey: ZIBIWQIKVLYOJG-PDBXOOCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  23
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Γ-十八碳三烯酸 、 乙二醇 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 2-hydroxyethyl linolenate
  参考文献：
  名称：

  二硫键桥连的多西他赛-脂肪酸前药及其自组装纳米粒

  摘要：

  本发明设计并合成了一系列还原敏感的二硫键桥连的多西他赛‑脂肪酸前药，这一系列的前药均能通过一步纳沉淀法自组装成纳米递药系统。该纳米递药系统具备以下几种优势：将多西他赛制备成二硫键连接的前药，降低了多西他赛母药的系统毒性，并且能够在肿瘤细胞内的高还原环境下特异性释放母药，实现增效减毒的效果；载药量高，且避免了毒性较大的增溶剂的使用，有望提高患者的耐受性和依从性；通过一步纳米沉淀法制备，制备工艺简单，易于规模化生产；纳米粒粒径小且均匀，易于通过EPR效应富集于肿瘤部位；易于表面修饰，可以通过PEG等修饰以减慢网状内皮系统的清除。

  公开号：

  CN112604002A

文献信息

• Incorporation of desired groups into polymers, the polymers so produced, and compositions containing them
  申请人：ZENECA LIMITED

  公开号：EP0442653A2

  公开（公告）日：1991-08-21

  Process for making a polymer with desired groups Y comprising reacting a precursor polymer having carbon- or nitrogen-bound -NH₂ and/or -NH- groups with at least one compound having a single enolic carbonyl group and at least one group Y. Also the polymer itself and a composition containing it.

  制造具有所需基团 Y 的聚合物的工艺，包括使具有与碳或氮结合的 -NH₂ 和/或 -NH- 基团的聚合物前体与至少一种具有单个烯醇羰基和至少一个基团 Y 的化合物反应。
• TACKIFIER DISPERSION
  申请人：Hexion Specialty Chemicals Research Belgium S.A.

  公开号：EP1730208A1

  公开（公告）日：2006-12-13
• OZONOLYSIS REACTIONS IN LIQUID CO2 AND CO2-EXPANDED SOLVENTS
  申请人：University Of Kansas

  公开号：EP2209547A2

  公开（公告）日：2010-07-28
• Tackifier dispersion
  申请人：Aarts Peter Mario Patrick

  公开号：US20050203228A1

  公开（公告）日：2005-09-15

  The invention relates to a tackifier dispersion comprising a resinous material and an emulsifier, the emulsifier being obtainable by a method comprising providing an ester of one or more fatty acids containing at least two conjugated double bonds, reacting the ester with a dienophile containing an acid or anhydride group, to form an intermediate product A, and, reacting the intermediate product A with one or more polyalkylene glycols. The invention also relates to a method for the production of a tackifier dispersion, its use as a tackifier, and an adhesive composition comprising the tackifier dispersion. The invention further relates to an emulsifier, a method of producing the same and its use for emulsifying resinous materials.
• Highly active lysophosphatidic acid and method of screening therewith
  申请人：Hayashi Akio

  公开号：US20070161604A1

  公开（公告）日：2007-07-12

  There is provided a method of screening a preventive and/or therapeutic substance for diseases in which LPA takes part, characterized in that a compound represented by any of formula (I), (II) and (III): [wherein the meaning of characters are described in the description] is used. The compounds obtained by the screening method or the screening kit of the present invention, their salts, their solvates and prodrugs thereof would modulate the binding of highly active LPA with LPA receptor in human and other mammals, so that they can be used as a preventive and/or therapeutic agent for diseases in which LPA takes part, for example, urinary diseases, central nervous diseases, inflammatory diseases, circulatory diseases, cancer, diabetes, immune system disorders and alimentary diseases.