clopidogrel nitrate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: clopidogrel nitrate
• 英文别名: methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate;nitric acid
• 化学式: C₁₆H₁₆ClNO₂S*HNO₃
• 分子量: 384.84
• InChiKey: DPWXIZXRYGDUFA-RSAXXLAASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.33
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  124
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  硝酸 、 氯吡格雷 以 乙醚 为溶剂， 以53.52%的产率得到clopidogrel nitrate
  参考文献：
  名称：

  WO2004/74215

  摘要：

  公开号：

文献信息

• PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS
  申请人：Nadkarni, Sunil Sadanand

  公开号：EP1606231A1

  公开（公告）日：2005-12-21
• IMMOBILISING BIOLOGICAL ENTITIES
  申请人：CARMEDA AB

  公开号：US20190275213A1

  公开（公告）日：2019-09-12

  There is provided inter alia a solid object having a surface comprising a layered coating of cationic and anionic polymer, wherein the outer coating layer is a layer comprising cationic polymer to which is covalently bound an anticoagulant entity; and wherein the anionic polymer is characterized by having (a) a total molecular weight of 20 kDa-650 kDa; and (b) a solution charge density of ≤4 μeq/g.
• [EN] PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS<br/>[FR] PROCEDE DE PREPARATION DE CLOPIDOGREL, SES SELS ET COMPOSITIONS PHARMACEUTIQUES
  申请人：NADKARNI SUNIL SADANAND

  公开号：WO2004074215A1

  公开（公告）日：2004-09-02

  The invention discloses an improved process for racemization of methyl (R)­(-) alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate , a stereoisomer formed in the synthesis of clopidogrel i.e. methyl (S)-(+)-alpha­ (2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate or its salts. The invention is also for an improved process for production of clopidogrel or its pharmaceutically acceptable salts. The invention further discloses novel clopidogrel salts and pharmaceutical compositions comprising them.
• [EN] IMPROVEMENTS TO IMMOBILISING BIOLOGICAL ENTITIES<br/>[FR] PERFECTIONNEMENTS APPORTÉS À L'IMMOBILISATION D'ENTITÉS BIOLOGIQUES
  申请人：CARMEDA AB

  公开号：WO2019170859A2

  公开（公告）日：2019-09-12

  There is provided inter alia a solid object having a surface comprising a layered coating of cationic and anionic polymer, wherein the outer coating layer is a layer comprising cationic polymer to which is covalently bound an anticoagulant entity; and wherein the anionic polymer is characterized by having (a) a total molecular weight of 20 kDa-650 kDa; and (b) a solution charge density of ≤4 μeq/g.