乙基3-苯基-2-(哌啶-1-基)丙酯 | 122806-10-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 乙基3-苯基-2-(哌啶-1-基)丙酯
• 英文名称: ethyl 3-phenyl-2-(piperidin-1-yl)propanoate
• 英文别名: ethyl 3-phenyl-2-piperidin-1-ylpropanoate
• CAS: 122806-10-4
• 化学式: C₁₆H₂₃NO₂
• 分子量: 261.364
• InChiKey: SBLOJVMHVGRPPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙基3-苯基-2-(哌啶-1-基)丙酯 、 碘甲烷 生成 1-(1-ethoxycarbonyl-2-phenyl-ethyl)-1-methyl-piperidinium; iodide
  参考文献：
  名称：

  KATRIZKY, ALAN R.;UROGDI, LASZLO;MAYENCE, ANNIE, SYNTHESIS,(1989) N, C. 323-327

  摘要：

  DOI：
• 作为产物：
  描述：

  Benzotriazol-1-yl-piperidin-1-yl-acetic acid ethyl ester 、 chlorozinc(1+),methanidylbenzene 生成 乙基3-苯基-2-(哌啶-1-基)丙酯
  参考文献：
  名称：

  KATRIZKY, ALAN R.;UROGDI, LASZLO;MAYENCE, ANNIE, SYNTHESIS,(1989) N, C. 323-327

  摘要：

  DOI：

文献信息

• The Chemistry of<i>N</i>-Substituted Benzotriazoles Part 23. Synthesis of Tertiary α-Amino Esters
  作者：Alan R. Katritzky、Laszlo Urogdi、Annie Mayence

  DOI：10.1055/s-1989-27244

  日期：——

  2-Dialkylaminoalkanoic esters 6 are prepared in good yield by the reaction of organozinc derivatives 5 with dialkylamino(1-benzo-triazolyl)acetic esters 4, obtained from the condensation of secondary amines 3 with ethyl glyoxylate 2 and benzotriazole (1).

  通过有机锌衍生物5与二烷基氨基(1-苯并三唑基)乙酸酯4的反应以良好收率制备2-二烷基氨基链烷酸酯6，所述二烷基氨基(1-苯并三唑基)乙酸酯4由仲胺3与乙醛酸乙酯2和苯并三唑(1)的缩合获得。
• A Straightforward Three-Component Synthesis of α-Amino Esters Containing a Phenylalanine or a Phenylglycine Scaffold
  作者：Caroline Haurena、Erwan Le Gall、Stéphane Sengmany、Thierry Martens、Michel Troupel

  DOI：10.1021/jo1002328

  日期：2010.4.16

  A range of alpha-amino esters has been synthesized in good to high yields using a straightforward three-component reaction among preformed or in situ generated aromatic or benzylic organozinc reagents, primary or secondary amines, and ethyl glyoxylate. The procedure, which is characterized by its simplicity, allows the concise synthesis of esters bearing a phenylglycine or a phenylalanine scaffold.
• Identification of inhibitors of the immunosuppressive enzyme IL4I1
  作者：Marc Presset、Diana Djordjevic、Aurélie Dupont、Erwan Le Gall、Valérie Molinier-Frenkel、Flavia Castellano

  DOI：10.1016/j.bioorg.2019.103463

  日期：2020.1
• KATRIZKY, ALAN R.;UROGDI, LASZLO;MAYENCE, ANNIE, SYNTHESIS,(1989) N, C. 323-327
  作者：KATRIZKY, ALAN R.、UROGDI, LASZLO、MAYENCE, ANNIE

  DOI：——

  日期：——
• PHENYLALANINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCERS
  申请人：UNIVERSITE PARIS EST CRETEIL VAL DE MARNE

  公开号：US20210023034A1

  公开（公告）日：2021-01-28

  The present invention relates to the field of medicine, in particular of oncology. Especially, it provides new compounds useful in the treatment of various cancers. The present invention relates more particularly to methods for the treatment of cancer with IL4I1 expressing cells.