N3MetAlaValPhe

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N3MetAlaValPhe
• 英文别名: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-azido-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoic acid
• 化学式: C₂₂H₃₂N₆O₅S
• 分子量: 492.599
• InChiKey: UQPSGFGKZNGNGO-DKIMLUQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  34
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  164
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  L-蛋氨酸 在 triflic azide 、 potassium carbonate 、 copper(II) sulfate 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 5.0h， 生成 N3MetAlaValPhe
  参考文献：
  名称：

  Improved Solid-Phase Peptide Synthesis Method Utilizing α-Azide-Protected Amino Acids

  摘要：

  [GRAPHICS]Pure alpha -azido acids were prepared using an efficient diazo transfer method followed by buffered workup, These building blocks were used to prepare small peptides on Wang resin by two approaches, Peptides prone to diketopiperazine formation were prepared in good yields by coupling acids to resin bound iminophosphoranes during Fmoc-Wang synthesis, The iminophosphoranes can also be hydrolyzed under neutral conditions to provide unprotected amines ready for further coupling.

  DOI：

  10.1021/ol0155485

文献信息

• Improved Solid-Phase Peptide Synthesis Method Utilizing α-Azide-Protected Amino Acids
  作者：Lundquist、Jeffrey C. Pelletier

  DOI：10.1021/ol0155485

  日期：2001.3.1

  [GRAPHICS]Pure alpha -azido acids were prepared using an efficient diazo transfer method followed by buffered workup, These building blocks were used to prepare small peptides on Wang resin by two approaches, Peptides prone to diketopiperazine formation were prepared in good yields by coupling acids to resin bound iminophosphoranes during Fmoc-Wang synthesis, The iminophosphoranes can also be hydrolyzed under neutral conditions to provide unprotected amines ready for further coupling.