Carbazole spermine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Carbazole spermine
• 英文别名: N-[3-[4-(3-aminopropylamino)butylamino]propyl]carbazole-9-carboxamide
• 化学式: C₂₃H₃₃N₅O
• 分子量: 395.548
• InChiKey: VWMYNZITOCPLFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  84.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  精胺 、 4-nitrophenyl 9H-carbazole-9-carboxylate 以 二氯甲烷 为溶剂， 生成 Carbazole spermine
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers

  摘要：

  We have developed a new class of N-methyl-D-aspartate (NMDA) channel blockers having a conjugate structure that consists of a nitrogenous heterocyclic head and a tetraamine tail. Among them, dihydrodibenzazepine-homospermine conjugate (8) exhibited potent antagonistic activity at NR1/NR2A or NR1/NR2B NMDA subtype receptors compared with the lead compound, AQ343 (1), or memantine, as well as weak cytotoxicity. Its superior biological profiles compared with known compounds point to its potential use as therapeutic agents for neurological disorders. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.06.069

文献信息

• COMPOUND HAVING ACTIVITY OF BLOCKING NMDA RECEPTOR CHANNEL, AND PHARMACEUTICAL AGENT USING THE SAME
  申请人：National University Corporation Chiba University

  公开号：EP2039354A1

  公开（公告）日：2009-03-25

  [PROBLEMS] To provide a novel compound having NMDA receptor channel blocking activity, and also a pharmaceutical agent comprising the compound. [MEANS FOR SOLVING PROBLEMS] A pharmaceutical agent for the treatment or prevention of a disease caused by overexcitation of an NMDA receptor, which comprises a compound having NMDA receptor channel blocking activity and represented by the formula (1), a salt thereof, or a hydrate of the compound or the salt.

  [问题] 提供一种具有 NMDA 受体通道阻断活性的新型化合物，以及一种包含该化合物的药剂。 [解决问题的方法] 一种用于治疗或预防由 NMDA 受体过度兴奋引起的疾病的药剂，它包括具有 NMDA 受体通道阻断活性并由式（1）表示的化合物、其盐或该化合物或该盐的水合物。
• COMPOUNDS BLOCKING THE NMDA RECEPTOR CHANNEL AND PHARMACEUTICAL AGENT USING THE SAME
  申请人：National University Corporation Chiba University

  公开号：EP2039354B1

  公开（公告）日：2011-06-29
• Compound Having Activity Of Blocking NMDA Receptor Channel, and Pharmaceutical Agent Using The Same
  申请人：Igarashi Kazuei

  公开号：US20090105223A1

  公开（公告）日：2009-04-23

  To provide a novel compound having NMDA receptor channel blocking activity, and also a pharmaceutical agent comprising the compound. A pharmaceutical agent for the treatment or prevention of a disease caused by overexcitation of an NMDA receptor, which comprises a compound having NMDA receptor channel blocking activity and represented by the formula ( 1 ), a salt thereof, or a hydrate of the compound or the salt.
• US8476258B2
  申请人：——

  公开号：US8476258B2

  公开（公告）日：2013-07-02
• US8987253B2
  申请人：——

  公开号：US8987253B2

  公开（公告）日：2015-03-24