1-bromo-2,4-difluoro-3-(trifluoromethyl)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-bromo-2,4-difluoro-3-(trifluoromethyl)benzene
• 英文别名: 3-Bromo-2,6-difluorobenzotrifluoride
• 化学式: C₇H₂BrF₅
• 分子量: 260.989
• InChiKey: SUHKWEINMZXPHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-bromo-2,4-difluoro-3-(trifluoromethyl)benzene 在 溴 、 sodium hydride 、 magnesium 、 溶剂黄146 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 27.5h， 生成 N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide
  参考文献：
  名称：

  [EN] AMIDES OF 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AND THEIR SALTS
  [FR] AMIDES DE COMPOSÉS DE 2-AMINO-4-ARYLTHIAZOLE ET LEURS SELS

  摘要：

  公开号：

  WO2013183035A3
• 作为产物：
  描述：

  2,6-二氟三氟甲基苯 在 铁粉 、 溴 作用下， 反应 2.08h， 以130 g的产率得到1-bromo-2,4-difluoro-3-(trifluoromethyl)benzene
  参考文献：
  名称：

  [EN] AMIDES OF 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AND THEIR SALTS
  [FR] AMIDES DE COMPOSÉS DE 2-AMINO-4-ARYLTHIAZOLE ET LEURS SELS

  摘要：

  公开号：

  WO2013183035A3

文献信息

• PROCESS OF MANUFACTURING POLYOLS
  申请人：Dow Global Technologies LLC

  公开号：US20200354383A1

  公开（公告）日：2020-11-12

  A method of producing a polyether polyol includes reacting a low molecular weight initiator with ethylene oxide in the presence of a polymerization catalyst, and the low molecular weight initiator has a nominal hydroxyl functionality at least 2. The polymerization catalyst is a Lewis acid catalyst having the general formula M(R 1 ) 1 (R 2 ) 1 (R 3 ) 1 (R 4 )0 or 1, whereas M is boron, aluminum, indium, bismuth or erbium, R 1 , R 2 , R 3 , and R 4 are each independent, R 1 includes a fluoroalkyl-substituted phenyl group, R 2 incudes a fluoroalkyl-substituted phenyl group or a fluoro/chloro-substituted phenyl group, R 3 includes a fluoroalkyl-substituted phenyl group or a fluoro/chloro-substituted phenyl group, and optional R 4 includes a functional group or functional polymer group, R 1 being different from at least one of R 2 and R 3 .

  一种生产聚醚多元醇的方法包括在聚合催化剂存在下，将低分子量启始剂与环氧乙烷反应，其中低分子量启始剂的名义羟基官能度至少为2。聚合催化剂是具有一般式M(R1)1(R2)1(R3)1(R4)0或1的路易斯酸催化剂，其中M为硼、铝、铟、铋或铒，R1、R2、R3和R4各自独立，R1包括氟烷基取代的苯基，R2包括氟烷基取代的苯基或氟/氯取代的苯基，R3包括氟烷基取代的苯基或氟/氯取代的苯基，可选的R4包括功能基或功能聚合物基，R1与至少一个R2和R3不同。
• Lewis acid polymerization catalyst
  申请人：Dow Global Technologies LLC

  公开号：US11001669B2

  公开（公告）日：2021-05-11

  A Lewis acid polymerization catalyst has a general formula M(R1)1(R2)1(R3)1(R4)0 or 1, whereas M is boron, R1, R2, R3, and R4 are each independent, R1 is a 3,5-bis(trifluoromethyl)-substituted phenyl group, R2 is the 3,5-bis(trifluoromethyl)-substituted phenyl group or a first fluoro-substituted phenyl group selected from Set 1 structures, R3 is independently a second fluoro-substituted phenyl group selected from the Set 1 structures, and optional R4 includes a third functional group or functional polymer group.

  一个路易斯酸聚合催化剂的一般公式是 M(R1)1(R2)1(R3)1(R4)0或1，其中 M 为硼，R1、R2、R3 和 R4 分别是独立的，R1 是一个3,5-双(三氟甲基)取代的苯基，R2 是3,5-双(三氟甲基)取代的苯基或从 Set 1 结构中选择的第一氟取代的苯基，R3 是从 Set 1 结构中选择的第二氟取代的苯基，可选的 R4 包括第三功能基或功能聚合物基团。
• [EN] ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES<br/>[FR] MOLÉCULES ORGANIQUES DESTINÉES EN PARTICULIER À ÊTRE UTILISÉES DANS DES DISPOSITIFS OPTOÉLECTRONIQUES
  申请人：CYNORA GMBH

  公开号：WO2018202840A1

  公开（公告）日：2018-11-08

  The invention relates to an organic molecule, in particular for use in organic optoelectronic devices. According to the invention, the organic molecule consists of - a first chemical moiety comprising or consisting of a structure of formula (I), Formula (I), and - two second chemical moieties, each at each occurrence independently from another comprising or consisting of a structure of formula (II), Formula (II) wherein the first chemical moiety is linked to each of the two second chemical moieties via a single bond; wherein T, V is independently from another the binding site of a single bond linking the first chemical moiety to one of the two second chemical moieties or is hydrogen; W, X, Y is independently from another the binding site of a single bond linking the first chemical moiety to one of the two second chemical moieties or is selected from the group consisting of hydrogen, CN and CF3; wherein exactly one substituent selected of the group consisting of W, X, and Y is CN or CF3, and exactly two substituents selected of the group consisting of T, V, W, X and Y represent the binding sites connecting of a single bond linking the first chemical moiety to one of the two second chemical moieties.

  本发明涉及一种有机分子，特别是用于有机光电子器件。根据本发明，该有机分子由以下组成：- 第一化学基团，包括或由式(I)的结构组成或构成，式(I)，- 两个第二化学基团，每个独立出现的化学基团包括或由式(II)的结构组成或构成，式(II)，其中第一化学基团通过单键与两个第二化学基团相连；其中T，V是独立的单键结合位点，将第一化学基团与两个第二化学基团之一相连或为氢；W，X，Y是独立的单键结合位点，将第一化学基团与两个第二化学基团之一相连，或选择自氢，CN和CF3的群组中，恰好有一个取代基选自W，X和Y的群组CN或CF3，恰好有两个取代基选自T，V，W，X和Y的群组，表示连接第一化学基团与两个第二化学基团之一的单键结合位点。
• Process of manufacturing surfactants and lubricants
  申请人：Dow Global Technologies LLC

  公开号：US11186683B2

  公开（公告）日：2021-11-30

  A method of producing an alcohol ethoxylate surfactant or lubricant includes reacting a low molecular weight initiator with ethylene oxide in the presence of a polymerization catalyst, the low molecular weight initiator having a nominal hydroxyl functionality at least 1, and the polymerization catalyst being a Lewis acid catalyst having the general formula M(R1)1(R2)1(R3)1(R4)0 or 1, whereas M is boron, aluminum, indium, bismuth or erbium, R1, R2 and R3 each includes a same fluoroalkyl-substituted phenyl group, and optional R4 includes a functional group or functional polymer group. R1, R2, and R3 are the same fluoroalkyl-substituted phenyl group. The method further includes forming the alcohol ethoxylate surfactant or lubricant having a number average molecular weight of greater than the number average molecular weight of the low molecular weight initiator in the presence of the Lewis acid catalyst.

  一种生产醇基乙氧基化表面活性剂或润滑剂的方法，包括在聚合催化剂的存在下，将低分子量引发剂与乙烯氧化物反应，所述低分子量引发剂具有名义羟基功能至少为1，所述聚合催化剂为具有一般式M(R1)1(R2)1(R3)1(R4)0或1的路易斯酸催化剂，其中M为硼、铝、铟、铋或铒，R1、R2和R3均包括相同的氟烷基取代苯基，可选的R4包括一个功能基团或功能聚合物基团。R1、R2和R3是相同的氟烷基取代苯基。该方法还包括在路易斯酸催化剂的存在下形成具有比低分子量引发剂的数均分子量更大的醇基乙氧基化表面活性剂或润滑剂。
• AMIDES OF 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AND THEIR SALTS
  申请人：GLENMARK PHARMACEUTICALS S.A.

  公开号：US20150111038A1

  公开（公告）日：2015-04-23

  The present disclosure is directed to salts of N-4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide and process for the preparation thereof (formula II).

  本公开涉及N-4-[2,4-二氟-3-(三氟甲基)苯基]-1,3-噻唑-2-基}二甲基-2,4-二氧杂-1,2,3,4-四氢噻吩[2,3-d]嘧啶-5-基)乙酰胺盐及其制备方法（化学式II）。