(2S)-N-[2-(3,4-dihydroxyphenyl)ethyl]-2-(acetamido)-3-(1H-imidazol-4-yl)propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-N-[2-(3,4-dihydroxyphenyl)ethyl]-2-(acetamido)-3-(1H-imidazol-4-yl)propanamide
• 英文别名: N-(3,4-dihydroxyphenethyl)-2-acetamido-3-(1H-imidazol-4-yl)propanamide；(2S)-2-acetamido-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(1H-imidazol-5-yl)propanamide
• 化学式: C₁₆H₂₀N₄O₄
• 分子量: 332.359
• InChiKey: HESYWAFSTNFGBH-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  L-组氨酸盐酸盐 在 sodium hydroxide 、 N,N-二甲氨基-2-氯丙烷盐酸盐 、 1-羟基苯并三唑 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 (2S)-N-[2-(3,4-dihydroxyphenyl)ethyl]-2-(acetamido)-3-(1H-imidazol-4-yl)propanamide
  参考文献：
  名称：

  A Magnetic Biomimetic Nanocatalyst for Cleaving Phosphoester and Carboxylic Ester Bonds under Mild Conditions

  摘要：

  As a result of the unique surface structure of nanospheres, Asp and His residues supported on a 12 nm maghemite nanoparticle worked collaboratively as a biomimetic nanocatalyst for hydrolyzing paraoxon (phosphoester) and 4-nitrophenyl acetate (carboxylic ester) in Milli-Q water (pH 7.0) at 37 degrees C, without employing extremes of pH or heavy metals. Our nanocatalyst could be facilely recovered via magnetic concentration. The isolated catalyst exhibited long-term stability, showing no significant loss of its catalytic activity for repeated uses after 3 months.

  DOI：

  10.1021/ol061098a

文献信息

• Magnetic Assembly and Patterning of Vesicle/Nanoparticle Aggregates
  作者：Kwan Ping Liem、Robert J. Mart、Simon J. Webb

  DOI：10.1021/ja075000e

  日期：2007.10.1

  that mimic tissue, patterned vesicle assemblies composed of phospholipid vesicles cross-linked by magnetic nanoparticles have been developed. Multivalent binding between synthetic adhesive lipids in the vesicle membranes and histidine-coated magnetite nanoparticles resulted in the reversible formation of large nanoparticle/vesicle aggregates. The nanoparticles did not insert into or otherwise disrupt

  作为旨在创造模拟组织的生物材料的努力的一部分，已经开发出由磁性纳米粒子交联的磷脂囊泡组成的图案化囊泡组件。囊泡膜中合成粘附脂质与组氨酸包被的磁铁矿纳米颗粒之间的多价结合导致大纳米颗粒/囊泡聚集体的可逆形成。纳米颗粒不会插入或以其他方式破坏囊泡膜的完整性，并且交联的囊泡保留了封装的物质。这些囊泡/纳米颗粒聚集体可以通过外部磁场操纵形成图案化的囊泡组件；例如，它们被压缩以形成让人联想到组织的层状材料，或在微流槽的不同腔室中压实。
• A Magnetic Biomimetic Nanocatalyst for Cleaving Phosphoester and Carboxylic Ester Bonds under Mild Conditions
  作者：Yan Zheng、Chuansong Duanmu、Yong Gao

  DOI：10.1021/ol061098a

  日期：2006.7.1

  As a result of the unique surface structure of nanospheres, Asp and His residues supported on a 12 nm maghemite nanoparticle worked collaboratively as a biomimetic nanocatalyst for hydrolyzing paraoxon (phosphoester) and 4-nitrophenyl acetate (carboxylic ester) in Milli-Q water (pH 7.0) at 37 degrees C, without employing extremes of pH or heavy metals. Our nanocatalyst could be facilely recovered via magnetic concentration. The isolated catalyst exhibited long-term stability, showing no significant loss of its catalytic activity for repeated uses after 3 months.