N-[2-(carboxymethoxy)ethyl]-N-(carboxy-methyl)glycine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[2-(carboxymethoxy)ethyl]-N-(carboxy-methyl)glycine
• 英文别名: 5-bis(carboxymethyl)amino-3-oxapentanoic acid；(2-carboxymethoxy-ethylimino)-di-acetic acid；2-(Bis-carboxymethyl-amino)-1-carboxymethoxy-aethan；(2-Carboxymethoxy-aethylamin)-N.N-diessigsaeure；(2-Carboxymethoxy-aethylimino)-di-essigsaeure；N-[2-(carboxymethoxy)ethyl]-N-(carboxymethyl)glycine；2-[2-(Carboxymethoxy)ethyl-(carboxymethyl)amino]acetic acid
• 化学式: C₈H₁₃NO₇
• 分子量: 235.194
• InChiKey: FHBLMACPTWZJFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  3-吗啉酮 、 氰基甲醇 甲醛氰醇 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 N-[2-(carboxymethoxy)ethyl]-N-(carboxy-methyl)glycine
  参考文献：
  名称：

  Intermediates for the preparation of N-[2-(carboxymethoxy)ethyl]-N-(carboxymethyl)glycine

  摘要：

  公式表示的化合物为其中R和R1独立地表示H、—CH2CN或—CH2CO2X，但R和R1不能同时为H或—CH2CO2X；X表示氢、碱金属或碱土金属。这些化合物可用作制备N-[2-(羧甲氧基)乙基]-N-(羧甲基)甘氨酸的中间化合物。这些中间体可以通过在碱性条件下将3-吗啉酮与甘腈接触形成氨基腈，再水解并与额外的甘腈接触形成腈中间体，然后通过水解将腈中间体转化为N-[2-(羧甲氧基)乙基]-N-(羧甲基)甘氨酸。

  公开号：

  US06288263B1

文献信息

• Intermediates for the preparation of N-[2-(carboxymethoxy) ethyl]-N-(carboxymethyl) glycine
  申请人：The Dow Chemical Company

  公开号：US06392095B2

  公开（公告）日：2002-05-21

  Compounds represented by the formula wherein R and R1 independently represent H, —CH2CN or —CH2CO2X, with the proviso that R and R1 can not be both H or —CH2CO2X; and X represents hydrogen, an alkali metal or alkaline earth metal are disclosed. These compounds are useful as intermediate compounds in the preparation of N-[2-(carboxymethoxy)ethyl]-N-(carboxy-methyl)glycine. These intermediates can be formed by contacting 3-morpholinone with glycolonitrile under alkaline conditions to form an aminonitrile which can be hydrolyzed and contacted with additional glycolonitrile to form the nitrile intermediate which can be converted to N-[2-(carboxymethoxy)ethyl]-N-(carboxymethyl)glycine via hydrolysis.

  公式表示的化合物中，其中R和R1分别表示H、—CH2CN或—CH2CO2X，但R和R1不能同时为H或—CH2CO2X；X表示氢、碱金属或碱土金属。这些化合物可作为N-[2-(羧甲氧基)乙基]-N-(羧甲基)甘氨酸制备中间体化合物。这些中间体可以通过在碱性条件下将3-吗啉酮与甘氰酸接触以形成氨基腈，然后水解并与额外的甘氰酸接触以形成腈中间体，最后通过水解将腈中间体转化为N-[2-(羧甲氧基)乙基]-N-(羧甲基)甘氨酸。
• Intermediates for the preparation of N-[2-(carboxymethoxy)ethyl]-N-(carboxymethyl)glycine
  申请人：The Dow Chemical Company

  公开号：US06288263B1

  公开（公告）日：2001-09-11

  Compounds represented by the formula wherein R and R1 independently represent H, —CH2CN or —CH2CO2X, with the proviso that R and R1 can not be both H or —CH2CO2X; and X represents hydrogen, an alkali metal or alkaline earth metal are disclosed. These compounds are useful as intermediate compounds in the preparation of N-[2-(carboxymethoxy)ethyl]-N-(carboxy-methyl)glycine. These intermediates can be formed by contacting 3-morpholinone with glycolonitrile under alkaline conditions to form an aminonitrile which can be hydrolyzed and contacted with additional glycolonitrile to form the nitrile intermediate which can be converted to N-[2-(carboxymethoxy)ethyl]-N-(carboxymethyl)glycine via hydrolysis.

  公式表示的化合物为其中R和R1独立地表示H、—CH2CN或—CH2CO2X，但R和R1不能同时为H或—CH2CO2X；X表示氢、碱金属或碱土金属。这些化合物可用作制备N-[2-(羧甲氧基)乙基]-N-(羧甲基)甘氨酸的中间化合物。这些中间体可以通过在碱性条件下将3-吗啉酮与甘腈接触形成氨基腈，再水解并与额外的甘腈接触形成腈中间体，然后通过水解将腈中间体转化为N-[2-(羧甲氧基)乙基]-N-(羧甲基)甘氨酸。
• Intermediates for the preparation of N-[2-(carboxymethoxy) ethyl]-N-(carboxymethyl) glycine
  申请人：——

  公开号：US20020010367A1

  公开（公告）日：2002-01-24

  Compounds represented by the formula 1 wherein R and R 1 independently represent H, —CH 2 CN or —CH 2 CO 2 X, with the proviso that R and R 1 can not be both H or —CH 2 CO 2 X; and X represents hydrogen, an alkali metal or alkaline earth metal are disclosed. These compounds are useful as intermediate compounds in the preparation of N-[2-(carboxymethoxy)ethyl]-N-(carboxy-methyl)glycine. These intermediates can be formed by contacting 3-morpholinone with glycolonitrile under alkaline conditions to form an aminonitrile which can be hydrolyzed and contacted with additional glycolonitrile to form the nitrile intermediate which can be converted to N-[2-(carboxymethoxy)ethyl]-N-(carboxymethyl)glycine via hydrolysis.

  本发明涉及一种由式1表示的化合物，其中R和R1分别独立表示H、—CH2CN或—CH2CO2X，但R和R1不能同时为H或—CH2CO2X；X表示氢、碱金属或碱土金属。这些化合物可用作制备N-［2-（羧甲氧基）乙基］-N-（羧甲基）甘氨酸的中间化合物。这些中间体可以通过在碱性条件下将3-吗啉酮与甘腈接触以形成氨基腈，然后水解并与额外的甘腈接触以形成腈中间体，然后通过水解将其转化为N-［2-（羧甲氧基）乙基］-N-（羧甲基）甘氨酸。
• Process for preparing carboxylic acids
  申请人：——

  公开号：US20010008948A1

  公开（公告）日：2001-07-19

  Aliphatic primary alcohols, including aliphatic primary alcohols possessing one or more oxygen, nitrogen and/or phosphorus heteroatoms that may be atoms substituting for carbon atoms in the alkyl group or component atoms of substituents on the alkyl group, were converted into salts of carboxylic acids by contacting an alkaline aqueous solution of the primary alcohol with a catalyst comprising cobalt, copper, and at least one of cerium, iron, zinc, and zirconium. Diethanolamine, for example, was converted to sodium iminodiacetate by treatment in an aqueous medium containing sodium hydroxide with a catalyst that was obtained by reducing a mixture of cobalt, copper, and zirconium oxides with hydrogen.

  脂肪族伯醇，包括具有一个或多个氧、氮和/或磷杂原子的脂肪族伯醇，这些杂原子可以是取代烷基中碳原子的原子或烷基上取代基的组分原子，通过将伯醇的碱性水溶液与由钴、铜以及铈、铁、锌和锆中的至少一种组成的催化剂接触，转化为羧酸盐。例如，二乙醇胺在含有氢氧化钠的水介质中与催化剂处理后，可转化为亚氨基二乙酸钠，该催化剂是通过用氢气还原钴、铜和锆氧化物混合物而得到的。
• PROCESS FOR PREPARING CARBOXYLIC ACIDS
  申请人：Dow AgroSciences LLC

  公开号：EP1114023A1

  公开（公告）日：2001-07-11