ethyl 2-[(N-3-phenylpropylamino)-sulfonyl]-3-methoxyphenylacetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-[(N-3-phenylpropylamino)-sulfonyl]-3-methoxyphenylacetate
• 英文别名: ethyl 2-[3-methoxy-2-(3-phenylpropylsulfamoyl)phenyl]acetate
• 化学式: C₂₀H₂₅NO₅S
• 分子量: 391.488
• InChiKey: MUAGKKUWMFFIQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  ethyl 2-[(N-3-phenylpropylamino)-sulfonyl]-3-methoxyphenylacetate 在 sodium methylate 作用下， 以 甲苯 为溶剂， 生成 6-methoxy-2-(3-phenylpropyl)-3-oxo-3,4-dihydro-2H-1,2-benzothiazine-1,1-dioxide
  参考文献：
  名称：

  Isoquinolyl substituted hydroxylamine derivatives

  摘要：

  该化合物的分子式为##STR1##其中R代表氢、较低的烷基、芳基、双芳基、C.sub.3 -C.sub.7 -环烷基、芳基-较低的烷基、芳基-较低的烯基、芳基-较低的炔基、芳氧基-较低的烷基、芳硫基-较低的烷基；C.sub.3 -C.sub.7 -环烷基-较低的烷基、双芳基-较低的烷基、芳基-C.sub.3 -C.sub.7 -环烷基、芳基-C.sub.3 -C.sub.7 -环烷基-较低的烷基或芳氧基-芳基-较低的烷基；芳基代表碳环芳基或杂环芳基；Z代表C.sub.1 -C.sub.3 -烷基或乙烯基，每个未取代或被较低的烷基取代；Y代表SO.sub.2或CO；A代表O、S或直接键；B代表较低的烷基；或者B代表较低的烯基，前提是A代表直接键；X代表氧或硫；R.sub.1代表氢、酰基、较低的烷氧羰基、氨基羰基、单取代或双较低的烷基氨基羰基、较低的烯基氨基羰基、较低的炔基氨基羰基、碳环芳基或杂环芳基-较低的烷基氨基羰基、碳环芳基或杂环芳基氨基羰基、C.sub.3 -C.sub.7 -环烷基氨基羰基或C.sub.3 -C.sub.7 -环烷基-较低的烷基氨基羰基；R.sub.2代表较低的烷基、较低的烷氧羰基-较低的烷基、C.sub.3 -C.sub.7 -环烷基、碳环芳基或杂环芳基、碳环芳基或杂环芳基-较低的烷基、C.sub.3 -C.sub.7 -环烷基-较低的烷基、氨基、单或双较低的烷基氨基、较低的烯基氨基、较低的炔基氨基、碳环芳基或杂环芳基-较低的烷基氨基、碳环芳基或杂环芳基氨基、C.sub.3 -C.sub.7 -环烷基氨基、C.sub.3 -C.sub.7 -环烷基-较低的烷基氨基或较低的烷氧羰基-较低的烷基氨基；R.sub.3和R.sub.4独立地代表氢或较低的烷基；R.sub.a代表氢、较低的烷基、卤素、三氟甲基或较低的烷氧基；以及它们的药学接受的盐；描述了它们的制备和用作脂氧酶抑制剂。

  公开号：

  US05260316A1
• 作为产物：
  描述：

  硫酸 、 3-甲氧基苯基乙酸乙酯 、 3-苯基-1-丙胺 、 三乙胺 在 氯磺酸 作用下， 以 乙醚 为溶剂， 生成 ethyl 2-[(N-3-phenylpropylamino)-sulfonyl]-3-methoxyphenylacetate
  参考文献：
  名称：

  Isoquinolyl substituted hydroxylamine derivatives

  摘要：

  该化合物的分子式为##STR1##其中R代表氢、较低的烷基、芳基、双芳基、C.sub.3 -C.sub.7 -环烷基、芳基-较低的烷基、芳基-较低的烯基、芳基-较低的炔基、芳氧基-较低的烷基、芳硫基-较低的烷基；C.sub.3 -C.sub.7 -环烷基-较低的烷基、双芳基-较低的烷基、芳基-C.sub.3 -C.sub.7 -环烷基、芳基-C.sub.3 -C.sub.7 -环烷基-较低的烷基或芳氧基-芳基-较低的烷基；芳基代表碳环芳基或杂环芳基；Z代表C.sub.1 -C.sub.3 -烷基或乙烯基，每个未取代或被较低的烷基取代；Y代表SO.sub.2或CO；A代表O、S或直接键；B代表较低的烷基；或者B代表较低的烯基，前提是A代表直接键；X代表氧或硫；R.sub.1代表氢、酰基、较低的烷氧羰基、氨基羰基、单取代或双较低的烷基氨基羰基、较低的烯基氨基羰基、较低的炔基氨基羰基、碳环芳基或杂环芳基-较低的烷基氨基羰基、碳环芳基或杂环芳基氨基羰基、C.sub.3 -C.sub.7 -环烷基氨基羰基或C.sub.3 -C.sub.7 -环烷基-较低的烷基氨基羰基；R.sub.2代表较低的烷基、较低的烷氧羰基-较低的烷基、C.sub.3 -C.sub.7 -环烷基、碳环芳基或杂环芳基、碳环芳基或杂环芳基-较低的烷基、C.sub.3 -C.sub.7 -环烷基-较低的烷基、氨基、单或双较低的烷基氨基、较低的烯基氨基、较低的炔基氨基、碳环芳基或杂环芳基-较低的烷基氨基、碳环芳基或杂环芳基氨基、C.sub.3 -C.sub.7 -环烷基氨基、C.sub.3 -C.sub.7 -环烷基-较低的烷基氨基或较低的烷氧羰基-较低的烷基氨基；R.sub.3和R.sub.4独立地代表氢或较低的烷基；R.sub.a代表氢、较低的烷基、卤素、三氟甲基或较低的烷氧基；以及它们的药学接受的盐；描述了它们的制备和用作脂氧酶抑制剂。

  公开号：

  US05260316A1

文献信息

• Indolyl substituted hydroxylamine derivatives
  申请人：Ciba-Geigy Corporation

  公开号：US05350761A1

  公开（公告）日：1994-09-27

  Disclosed are the compound of the formula ##STR1## wherein R represents hydrogen, lower alkyl, aryl, biaryl, C.sub.3 -C.sub.7 -cycloalkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl-lower alkynyl, aryloxy-lower alkyl, arylthio-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl, biaryl-lower alkyl, aryl-C.sub.3 -C.sub.7 -cycloalkyl, aryl-C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl or aryloxy-aryl-lower alkyl; and aryl represents carbocyclic or heterocyclic aryl; Z represents C.sub.1 -C.sub.3 -alkylene or vinylene, each unsubstituted or substituted by lower alkyl; Y represents SO.sub.2 (sulfonyl) or CO (carbonyl); A represents O (oxygen), S (sulfur), or a direct bond; B represents lower alkylene; or B represents lower alkenylene provided that A represents a direct bond; X represents oxygen or sulfur, R.sub.1 represents hydrogen, acyl, lower alkoxycarbonyl, aminocarbonyl, mono- or di-lower alkylaminocarbonyl, lower alkenylaminocarbonyl, lower alkynylaminocarbonyl, carbocyclic or heterocyclic aryl-lower alkylaminocarbonyl, carbocyclic or heterocyclic arylaminocarbonyl, C.sub.3 -C.sub.7 -cycloalkylaminocarbonyl or C.sub.3 -C.sub.7 -cycloalkyl-lower alkylaminocarbonyl; R.sub.2 represents lower alkyl, lower alkoxycarbonyl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl, amino, mono- or di-lower alkylamino, lower alkenylamino, lower alkynylamino, carbocyclic or heterocyclic aryl-lower alkylamino, carbocyclic or heterocyclic arylamino, C.sub.3 -C.sub.7 -cycloalkylamino, C.sub.3 -C.sub.7 -cycloalkyl-lower alkylamino or lower alkoxycarbonyl-lower alkylamino; R.sub.3 and R.sub.4 independently represent hydrogen or lower alkyl; R.sub.a represents hydrogen, lower alkyl, halo, trifluoromethyl or lower alkoxy; and pharmaceutically acceptable salts thereof; which are useful as lipoxygenase inhibitors.

  公开了式为##STR1##的化合物，其中R代表氢，低级烷基，芳基，双芳基，C.sub.3-C.sub.7-环烷基，芳基-低级烷基，芳基-低烯基，芳基-低炔基，芳氧基-低级烷基，芳硫基-低级烷基，C.sub.3-C.sub.7-环烷基-低级烷基，双芳基-低级烷基，芳基-C.sub.3-C.sub.7-环烷基，芳基-C.sub.3-C.sub.7-环烷基-低级烷基或芳氧基-芳基-低级烷基；芳基代表碳环芳基或杂环芳基；Z代表C.sub.1-C.sub.3-烷基或乙烯基，每个未取代或取代为低级烷基；Y代表SO.sub.2（磺酰基）或CO（羰基）；A代表O（氧）、S（硫）或直接键；B代表低级烷基；或B代表低烯基，前提是A代表直接键；X代表氧或硫，R.sub.1代表氢，酰基，低级烷氧羰基，氨基羰基，单或双低级烷基氨基羰基，低烯基氨基羰基，低炔基氨基羰基，碳环芳基或杂环芳基-低级烷基氨基羰基，碳环芳基或杂环芳基氨基羰基，C.sub.3-C.sub.7-环烷基氨基羰基或C.sub.3-C.sub.7-环烷基-低级烷基氨基羰基；R.sub.2代表低级烷基，低级烷氧羰基-低级烷基，C.sub.3-C.sub.7-环烷基，碳环芳基或杂环芳基，碳环芳基或杂环芳基-低级烷基，C.sub.3-C.sub.7-环烷基-低级烷基，氨基，单或双低级烷基氨基，低烯基氨基，低炔基氨基，碳环芳基或杂环芳基-低级烷基氨基，碳环芳基或杂环芳基氨基，C.sub.3-C.sub.7-环烷基氨基，C.sub.3-C.sub.7-环烷基-低级烷基氨基或低级烷氧羰基-低级烷基氨基；R.sub.3和R.sub.4独立地代表氢或低级烷基；R.sub.a代表氢，低级烷基，卤素，三氟甲基或低烷氧基；以及其药学上可接受的盐；它们可用作脂氧合酶抑制剂。
• Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors
  申请人：CIBA-GEIGY AG

  公开号：EP0526402A1

  公开（公告）日：1993-02-03

  Disclosed are the compound of the formula wherein    R represents hydrogen, lower alkyl, aryl, biaryl, C₃-C₇-cycloalkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl-lower alkynyl, aryloxy-lower alkyl, arylthio-lower alkyl, C₃-C₇-cycloalkyl-lower alkyl, biaryl-lower alkyl, aryl-C₃-C₇-cycloalkyl, aryl-C₃-C₇-cycloalkyl-lower alkyl or aryloxy-aryl-lower alkyl; and aryl represents carbocyclic or heterocyclic aryl;    Z represents C₁-C₃-alkylene or vinylene, each unsubstituted or substituted by lower alkyl;    Y represents SO₂ (sulfonyl) or CO (carbonyl);    A represents O (oxygen), S (sulfur), or a direct bond;    B represents lower alkylene; or B represents lower alkenylene provided that A represents a direct bond;    X represents oxygen or sulfur,    R₁ represents hydrogen, acyl, lower alkoxycarbonyl, aminocarbonyl, mono- or di-lower alkylaminocarbonyl, lower alkenylaminocarbonyl, lower alkynylaminocarbonyl, carbocyclic or heterocyclic aryl-lower alkylaminocarbonyl, carbocyclic or heterocyclic arylaminocarbonyl, C₃-C₇-cycloalkylaminocarbonyl or C₃-C₇-cycloalkyl-lower alkylaminocarbonyl;    R₂ represents lower alkyl, lower alkoxycarbonyl-lower alkyl, C₃-C₇-cycloalkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C₃-C₇-cycloalkyl-lower alkyl, amino, mono- or di-lower alkylamino, lower alkenylamino, lower alkynylamino, carbocyclic or heterocyclic aryl-lower alkylamino, carbocyclic or heterocyclic arylamino, C₃-C₇-cycloalkylamino, C₃-C₇-cycloalkyl-lower alkylamino or lower alkoxycarbonyl-lower alkylamino;    R₃ and R₄ independently represent hydrogen or lower alkyl;    Ra represents hydrogen, lower alkyl, halo, trifluoromethyl or lower alkoxy; and pharmaceutically acceptable salts thereof; which are useful as lipoxygenase inhibitors.

  公开了式中的化合物 其中 R 代表氢、低级烷基、芳基、双芳基、C₃-C₇-环烷基、芳基-低级烷基、芳基-低级烯基、芳基-低级炔基、芳氧基-低级烷基、芳硫基-低级烷基、C₃-C₇-环烷基-低级烷基、双芳基-低级烷基、芳基-C₃-C₇-环烷基、芳基-C₃-C₇-环烷基-低级烷基或芳氧基-芳基-低级烷基；芳基代表碳环芳基或杂环芳基； Z 代表 C₁-C₃-亚烷基或乙烯基，各自未被低级烷基取代或被低级烷基取代； Y 代表 SO₂（磺酰基）或 CO（羰基）； A 代表 O（氧）、S（硫）或直接键； B 代表低级亚烷基；或 B 代表低级烯基，条件是 A 代表直接键； X 代表氧或硫、 R₁ 代表氢、酰基、低级烷氧基羰基、氨基羰基、单-或双-低级烷基氨基羰基、低级烯基氨基羰基、低级炔基氨基羰基、碳环或杂环芳基-低级烷基氨基羰基、碳环或杂环芳基氨基羰基、C₃-C₇-环烷基氨基羰基或 C₃-C₇-环烷基-低级烷基氨基羰基； R₂ 代表低级烷基、低级烷氧基羰基-低级烷基、C₃-C₇-环烷基、碳环或杂环芳基、碳环或杂环芳基-低级烷基、C₃-C₇-环烷基-低级烷基、氨基、单-或双-低级烷基氨基、低级烯基氨基、低级炔基氨基、碳环或杂环芳基-低级烷基氨基、碳环或杂环芳基氨基、C₃-C₇-环烷基氨基、C₃-C₇-环烷基-低级烷基氨基或低级烷氧基羰基-低级烷基氨基； R₃ 和 R₄ 各自代表氢或低级烷基； Ra代表氢、低级烷基、卤代、三氟甲基或低级烷氧基；及其药学上可接受的盐；它们可用作脂氧合酶抑制剂。
• US5260316A
  申请人：——

  公开号：US5260316A

  公开（公告）日：1993-11-09
• US5350761A
  申请人：——

  公开号：US5350761A

  公开（公告）日：1994-09-27
• Isoquinolyl substituted hydroxylamine derivatives
  申请人：Ciba-Geigy Corporation

  公开号：US05260316A1

  公开（公告）日：1993-11-09

  The compounds of the formula ##STR1## wherein R represents hydrogen, lower alkyl, aryl, biaryl, C.sub.3 -C.sub.7 -cycloalkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl-lower alkynyl, aryloxy-lower alkyl, arylthio-lower alkyl; C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl, biaryl-lower alkyl, aryl-C.sub.3 -C.sub.7 -cycloalkyl, aryl-C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl or aryloxy-aryl-lower alkyl; and aryl represents carbocyclic or heterocyclic aryl; Z represents C.sub.1 -C.sub.3 -alkylene or vinylene, each unsubstituted or substituted by lower alkyl; Y represents SO.sub.2 or CO; A represents O, S, or a direct bond; B represents lower alkylene; or B represents lower alkenylene provided that A represents a direct bond; X represents oxygen or sulfur; R.sub.1 represents hydrogen, acyl, lower alkoxycarbonyl, aminocarbonyl, mono or di-lower alkylaminocarbonyl, lower alkenylaminocarbonyl, lower alkynylaminocarbonyl, carbocyclic or heterocyclic aryl-lower alkylaminocarbonyl, carbocyclic or heterocyclic arylaminocarbonyl, C.sub.3 -C.sub.7 -cycloalkylaminocarbonyl or C.sub.3 -C.sub.7 -cycloalkyl-lower alkylaminocarbonyl; R.sub.2 represents lower alkyl, lower alkoxycarbonyl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl-lower alkyl, amino, mono- or di-lower alkylamino, lower alkenylamino, lower alkynylamino, carbocyclic or heterocyclic aryl-lower alkylamino, carbocyclic or heterocyclic arylamino, C.sub.3 -C.sub.7 -cycloalkylamino, C.sub.3 -C.sub.7 -cycloalkyl-lower alkylamino or lower alkoxycarbonyl-lower alkylamino; R.sub.3 and R.sub.4 independently represent hydrogen or lower alkyl; R.sub.a represents hydrogen, lower alkyl, halo, trifluoromethyl or lower alkoxy; and pharmaceutically acceptable salts thereof; their preparation and use as lipoxygenase inhibitors are described.

  该化合物的分子式为##STR1##其中R代表氢、较低的烷基、芳基、双芳基、C.sub.3 -C.sub.7 -环烷基、芳基-较低的烷基、芳基-较低的烯基、芳基-较低的炔基、芳氧基-较低的烷基、芳硫基-较低的烷基；C.sub.3 -C.sub.7 -环烷基-较低的烷基、双芳基-较低的烷基、芳基-C.sub.3 -C.sub.7 -环烷基、芳基-C.sub.3 -C.sub.7 -环烷基-较低的烷基或芳氧基-芳基-较低的烷基；芳基代表碳环芳基或杂环芳基；Z代表C.sub.1 -C.sub.3 -烷基或乙烯基，每个未取代或被较低的烷基取代；Y代表SO.sub.2或CO；A代表O、S或直接键；B代表较低的烷基；或者B代表较低的烯基，前提是A代表直接键；X代表氧或硫；R.sub.1代表氢、酰基、较低的烷氧羰基、氨基羰基、单取代或双较低的烷基氨基羰基、较低的烯基氨基羰基、较低的炔基氨基羰基、碳环芳基或杂环芳基-较低的烷基氨基羰基、碳环芳基或杂环芳基氨基羰基、C.sub.3 -C.sub.7 -环烷基氨基羰基或C.sub.3 -C.sub.7 -环烷基-较低的烷基氨基羰基；R.sub.2代表较低的烷基、较低的烷氧羰基-较低的烷基、C.sub.3 -C.sub.7 -环烷基、碳环芳基或杂环芳基、碳环芳基或杂环芳基-较低的烷基、C.sub.3 -C.sub.7 -环烷基-较低的烷基、氨基、单或双较低的烷基氨基、较低的烯基氨基、较低的炔基氨基、碳环芳基或杂环芳基-较低的烷基氨基、碳环芳基或杂环芳基氨基、C.sub.3 -C.sub.7 -环烷基氨基、C.sub.3 -C.sub.7 -环烷基-较低的烷基氨基或较低的烷氧羰基-较低的烷基氨基；R.sub.3和R.sub.4独立地代表氢或较低的烷基；R.sub.a代表氢、较低的烷基、卤素、三氟甲基或较低的烷氧基；以及它们的药学接受的盐；描述了它们的制备和用作脂氧酶抑制剂。