2-oxopropyl 4-chlorobenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-oxopropyl 4-chlorobenzoate
• 化学式: C₁₀H₉ClO₃
• 分子量: 212.633
• InChiKey: MRUJKQHYYZTVCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  sodium p-chlorobenzoate 、 一氯丙酮 在 IRA-400 作用下， 生成 2-oxopropyl 4-chlorobenzoate
  参考文献：
  名称：

  Polymer Supported Reagents: Facile Synthesis of β-Oxalkyl (Acetonyl) Esters of Carboxylic Acids.

  摘要：

  beta-Oxoalkyl (acetonyl) esters have been synthesised in high yields and in a state of purity by reaction of chloroacetone with insoluble polymer supported carboxylate ions at room temperature.

  DOI：

  10.1080/00397919708004165

文献信息

• Microwave-Enhanced Coupling of Carboxylic Acids with Liquid Ketones and Cyclic Ethers Using Tetrabutylammonium Iodide/<i>t</i>-Butyl Hydroperoxide
  作者：Pablo Macías-Benítez、F. Javier Moreno-Dorado、Francisco M. Guerra

  DOI：10.1021/acs.joc.0c00519

  日期：2020.5.1

  The oxidative coupling of carboxylic acids with liquid ketones and cyclic ethers has been accomplished in minutes using t-butyl hydroperoxide in the presence of tetrabutylammonium iodide under microwave irradiation in the absence of a solvent. In addition to drastically shortening the reaction times, the use of microwaves resulted, in general, in yields equal to or higher than those obtained by conventional

  在叔丁基碘化铵存在下，在无溶剂的情况下，在微波辐射下，使用叔丁基氢过氧化物在几分钟之内完成了羧酸与液态酮和环醚的氧化偶联。除了大大缩短反应时间之外，使用微波通常还产生等于或高于通过常规加热获得的产率。
• Oxidative C–H Acyloxylation of Acetone with Carboxylic Acids under Iodine Catalysis
  作者：Xiao-Yu Zhou、Xia Chen

  DOI：10.1055/a-1336-5720

  日期：2021.5

  Iodine-catalyzed oxidative C(sp3)–H acyloxylation of acetone with carboxylic acids has been developed. The method employs iodide­ as catalyst and sodium chlorite as oxidant. Substituted benzoic acids, naphthoic acids and heteroaromatic carboxylic acids can be used, and 2-oxopropyl carboxylates are obtained with good to excellent yields.

  已开发出碘催化丙酮与羧酸的氧化C（sp3）–H酰氧基化丙酮。该方法以碘化物为催化剂，亚氯酸钠为氧化剂。可以使用取代的苯甲酸，萘甲酸和杂芳族羧酸，并且以良好或优异的产率获得2-氧代丙基羧酸盐。
• KI-catalyzed α-acyloxylation of acetone with carboxylic acids
  作者：Ya-Dong Wu、Bei Huang、Yue-Xin Zhang、Xiao-Xu Wang、Jian-Jun Dai、Jun Xu、Hua-Jian Xu

  DOI：10.1039/c6ob00876c

  日期：——

  The KI-catalyzed reaction of acetone with aromatic carboxylic acids is achieved, leading to α-acyloxycarbonyl compounds in good to excellent yields under mild reaction conditions. The present method exhibits good functional-group compatibility. Notably, this reaction system is even suitable for cinnamic acid, 3-phenylpropiolic acid and 4-phenylbutanoic acid. A kinetic isotope effect (KIE) study indicates

  丙酮与芳族羧酸的KI催化反应得以实现，从而在温和的反应条件下以良好至极佳的收率得到了α-酰氧基羰基化合物。本方法表现出良好的官能团相容性。值得注意的是，该反应体系甚至适用于肉桂酸，3-苯基丙酸和4-苯基丁酸。动力学同位素效应（KIE）研究表明，丙酮的C–H裂解是催化循环中的限速步骤。
• TBAI/TBHP mediated oxidative cross coupling of ketones with phenols and carboxylic acids: Direct access to benzofurans
  作者：P. Santhosh Kumar、B. Ravikumar、K. Chinna Ashalu、K. Rajender Reddy

  DOI：10.1016/j.tetlet.2017.11.043

  日期：2018.1

  TBAI/TBHP mediated oxidative cross coupling of phenols and carboxylic acids with ketones has been reported under metal-free, base free, solvent free conditions enabling environmentally benign synthesis of aryloxyketones, acyloxy ketones and benzofurans. Phenoxyketones and acyloxylcarbonyl compounds were synthesized in good to high yields, where as benzofurans were synthesized in moderate yields. This

  TBAI / TBHP介导的苯酚和羧酸与酮的氧化交叉偶联是在无金属，无碱，无溶剂的条件下进行的，能够对芳氧基酮，酰氧基酮和苯并呋喃进行环境友好的合成。苯氧基酮和酰氧基羰基化合物的合成产率高至高，而苯并呋喃的合成产率中等。该方法操作简便，可使用市售的廉价TBAI和氧化剂TBHP在温和的条件下工作。
• [EN] INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE CYSTÉINE PROTÉASES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：PARDES BIOSCIENCES INC

  公开号：WO2021252644A1

  公开（公告）日：2021-12-16

  The disclosure provides compounds of formula II with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease. Formula II